Subfoveal choriocapillaris, Sattler's and Haller's layer thickness predict clinical response to stereotactic radiotherapy in neovascular age-related macular degeneration patients

Ranjbar, Mahdy; Prasuhn, Michelle; Kurz, Maximilian; Holzhey, Annekatrin; Rommel, Felix; Brinkmann, Max; Rades, Dirk; Grisanti, Salvatore

doi:10.1016/j.joco.2018.12.004

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following previously published protocols, subfoveal choroidal thickness (SFCT), as well as the thickness of the choroidal vascular sublayers, such as choriocapillaris (CC), Sattler's layer (SL), and Haller's layer (HL), were measured manually in the EDI-OCT scans [15,21]. Manual measurements were performed by two experienced graders who were blinded to the clinical information of the examined eyes.…”

Section: Methodsmentioning

confidence: 99%

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Rommel

Prangel

Prasuhn

et al. 2021

Orphanet J Rare Dis

Self Cite

View full text Add to dashboard Cite

Purpose To investigate the correlation between retinal and choroidal microperfusion in patients with systemic sclerosis (SSc) using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study SSc patients without clinical evidence of ocular involvement and healthy, age- and sex-matched volunteers were recruited. Participants underwent specific rheumatological and ophthalmological examinations, including optical coherence tomography (OCT) and OCTA. Retinal and choroidal thicknesses as well as perfusion of the retina and the choroidal sublayers were evaluated. Results A total of 15 SSc patients (30 eyes) with a median disease duration of 60 months and 15 matched, healthy controls (30 eyes) were recruited. OCT data revealed a significantly lower macular volume, as well as Sattler’s layer and Haller’s layer thickness in SSc patients compared to controls. In OCTA analysis, the perfusion of both retinal plexus as well as Sattler’s and Haller’s layer were significantly reduced in the SSc group. Patients with a disease duration of more than 60 months showed a statistically significant positive correlation between retinal and choroidal malperfusion, while those with a shorter disease duration did not. Conclusion OCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. In early stages, either the retinal or the choroidal perfusion seems to be involved, while later on, vascular impairment affects both tissues alike. Both, retinal and choroidal examinations should be considered as soon as the diagnosis of SSc is made, to avoid missing out on early alterations.

show abstract

Section: Methodsmentioning

confidence: 99%

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Rommel

Prangel

Prasuhn

et al. 2021

Orphanet J Rare Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…A Sattler's layer is one of the medium-sized vessel layers, while Haller's layer is the dilatation of the outer layer containing the large vessels [83]. Incorporating subfoveal choroidal thickness, choriocapillaris, and Sattler's and Haller's layer thicknesses into a linear regression model improved the coefficient of determination for the number of intravitreal injections needed after stereotactic radiotherapy [84]. It has been demonstrated that Sattler's and Haller's choroidal sublayers thin significantly with increasing axial eye length (and to a lesser extent with aging) in healthy eyes.…”

Section: Choroidal Layersmentioning

confidence: 99%

Prognostic Optical Coherence Tomography Biomarkers in Neovascular Age-Related Macular Degeneration

Nawash

Ong

Driban

et al. 2023

JCM

View full text Add to dashboard Cite

Optical coherence tomography has revolutionized the diagnosis and management of neovascular age-related macular degeneration. OCT-derived biomarkers have the potential to further guide therapeutic advancements with anti-vascular endothelial growth factor; however, the clinical convergence between these two tools remains suboptimal. Therefore, the aim of this review of literature was to examine the current data on OCT biomarkers and their prognostic value. Thirteen biomarkers were analyzed, and retinal fluid had the strongest-reported impact on clinical outcomes, including visual acuity, clinic visits, and anti-VEGF treatment regimens. In particular, intra-retinal fluid was shown to be associated with poor visual outcomes. Consistencies in the literature with regard to these OCT prognostic biomarkers can lead to patient-specific clinical decision making, such as early-initiated treatment and proactive monitoring. An integrated analysis of all OCT components in combination with new efforts toward automated analysis with artificial intelligence has the potential to further improve the role of OCT in nAMD therapy.

show abstract

In vitro evaluation of simulated stereotactic radiotherapy for wet age-related macular degeneration on three different cell lines

Vounotrypidis

Hillenmayer

Wertheimer

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Low energy stereotactic radiotherapy has been proposed for the treatment of neovascular age related macular degeneration. We investigated the in vitro effect of the radiotherapy on pericytes, retinal pigment epithelium and endothelial cells. Primary human retinal pigment epithelium cells, human umbilical vein endothelial cells and human pericytes from Placenta were cultivated. In a pairwise protocol, one plate was irradiated at a dose of 16 Gy, while the second plate served as a non-irradiated control. Thereafter, cells were cultivated either in serum-free (non-permissive) or serum-stimulated (permissive) conditions. A life/dead assay, an XTT and a BrdU assay were performed up to 7 days after irradiation. No cell death occurred at any timepoint in any cell line after treatment nor in the control. Compared to the unirradiated controls, cell viability and metabolic activity were significantly reduced in irradiated cells in the XTT assay, except for non-permissive RPE cells. In the BrdU assay, proliferation was inhibited. While no cell death was detected in vitro, viability and proliferative capacity of all cell lines were significantly reduced. Therefore, it seems that low energy stereotactic radiotherapy inhibits angiogenesis without a direct induction of apoptosis but influencing microvascular function and stability.

show abstract

Subfoveal choriocapillaris, Sattler's and Haller's layer thickness predict clinical response to stereotactic radiotherapy in neovascular age-related macular degeneration patients

Cited by 3 publications

References 13 publications

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Prognostic Optical Coherence Tomography Biomarkers in Neovascular Age-Related Macular Degeneration

In vitro evaluation of simulated stereotactic radiotherapy for wet age-related macular degeneration on three different cell lines

Contact Info

Product

Resources

About