Subfoveal Choroidal Blood Flow and Central Retinal Function in Retinitis Pigmentosa

Falsini, Benedetto; Anselmi, Giorgia; Marangoni, Dario; D’Esposito, Fabiana; Fadda, Antonello; Renzo, Antonio Di; Campos, Emilio C.; Riva, Charles E.

doi:10.1167/iovs.10-5964

Cited by 95 publications

(83 citation statements)

References 21 publications

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“…Choroidal blood flow studies in RP patients6 and fluorescein angiography studies in RP patients,13–15 further support our findings that choroidal circulation and volume are reduced in RP. Falsini and associates6 demonstrated that RP patients with preserved vision have reduced subfoveal choroidal blood flow, and that there appears to be an association between choroidal blood flow and retinal function as measured by focal macular electroretinograms, further implicating the role of choroidal circulation in the pathogenesis of RP.…”

Section: Discussionsupporting

confidence: 75%

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Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

et al. 2012

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Section: Discussionsupporting

confidence: 75%

“…The known genes encode phototransduction cascade proteins, retinol metabolism and cell–cell interaction proteins, photoreceptor structural proteins and transcription factors among other proteins 6. While many of these genes only cause a small proportion of RP cases, several account for a relatively larger proportion.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

et al. 2012

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“…Indeed, both retinal and choroidal blood flow have previously been shown to be reduced in patients with RP, by using color Doppler imaging and laser Doppler flowmetry [2–4, 35, 36], and fluorescein angiography studies further support that choroidal circulation and volume are reduced and disturbed in RP [37–39]. …”

Section: Discussionmentioning

confidence: 97%

ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa

Strobbe

Cellini

Fresina

et al. 2015

Journal of Ophthalmology

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Purpose. To assess endothelin-1 (ET-1) plasma levels, choroidal thickness, and aqueous flare in patients with early stage retinitis pigmentosa (RP) and to search for possible correlations. Methods. We compared 24 RP patients with 24 healthy controls. Choroidal thickness and aqueous flare were measured, respectively, by using a spectral domain optical coherence tomography and a laser flare-cell meter, whereas plasma samples were obtained from each patient to evaluate ET-1 plasma levels. Results. Notably, RP subjects showed significantly increased ET-1 plasma levels and reduced choroidal thickness compared with controls: 2.143 ± 0.258 versus 1.219 ± 0.236 pg/mL, P < 0.002, and 226.75 ± 76.37 versus 303.9 ± 39.87 μm, P < 0.03, respectively. Higher aqueous flare values were also demonstrated in RP compared to controls: in detail, 10.51 ± 3.97 versus 5.66 ± 1.29 photon counts/ms, P < 0.0001. Spearman's correlation test highlighted that the increase of ET-1 plasma levels was related with the decrease of choroidal thickness (r = −0.702; P < 0.023) and the increase of aqueous flare (r = 0.580; P < 0.007). Conclusions. Early stage RP patients show a breakdown of blood-ocular barrier and increased ET-1 plasma levels and these findings may contribute to the reduction of choroidal thickness.

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“…Several studies have reported altered choroid circulation in patients with RP (Falsini et al. 2011). However, there is a lack of agreement on the findings of flow area in the choriocapillaris between two previous studies: while Parodi et al.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Takagi

Hirami

Takahashi

et al. 2018

Acta Ophthalmologica

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PurposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti®) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA).MethodsThis was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis.ResultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).ConclusionOptical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.

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Subfoveal Choroidal Blood Flow and Central Retinal Function in Retinitis Pigmentosa

Abstract: These data indicate significant alterations of subfoveal choroidal hemodynamic in RP and suggest a link between the alteration of ChBF and the RP-associated central cone-mediated dysfunction as assessed by the FERG.

Cited by 95 publications

References 21 publications

Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

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