Sublingual immunotherapy: The optimism and the issues

Pajno, Giovanni Battista

doi:10.1016/j.jaci.2007.01.009

Cited by 41 publications

(33 citation statements)

References 61 publications

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“…Immunotherapy remains the only truly disease-modifying treatment for asthma (45,46). Despite its efficacy, s.c. allergen immunotherapy has several drawbacks.…”

Section: Il-10mentioning

confidence: 99%

“…One of the factors limiting the use of s.c. allergen immunotherapy is the inconvenience of repeated clinic visits over several years to receive the injections and to achieve sustainable therapeutic results (45,46). More importantly, s.c. allergen immunotherapy is not entirely free of side effects and there is the rare but existing risk of severe anaphylactic reaction, even when standardized extracts are used (45,46). To avoid these problems, alternative forms of immunotherapy have been developed.…”

Section: Il-10mentioning

confidence: 99%

“…To avoid these problems, alternative forms of immunotherapy have been developed. Among them, sublingual immunotherapy offers logistic advantages and is safe (45,46). However, much higher doses of sublingually administered allergens are required to obtain beneficial results, demonstrating that sublingual immunotherapy is less effective than s.c. allergen immunotherapy (45,46).…”

Section: Il-10mentioning

confidence: 99%

See 2 more Smart Citations

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

Henry¹,

Desmet

Garzé³

et al. 2008

The Journal of Immunology

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“…Immunotherapy remains the only truly disease-modifying treatment for asthma (45,46). Despite its efficacy, s.c. allergen immunotherapy has several drawbacks.…”

Section: Il-10mentioning

confidence: 99%

Section: Il-10mentioning

confidence: 99%

Section: Il-10mentioning

confidence: 99%

See 1 more Smart Citation

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

Henry¹,

Desmet

Garzé³

et al. 2008

The Journal of Immunology

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“…Clinical symptoms and airway inflammation in asthmatic patients are attenuated by immunotherapy [1,2,3,11]. However, this therapy hardly affects IgE synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…There are plenty of possible allergen administration routes, though only subcutaneous and sublingual immunotherapy has been clinically applied [1,2,3]. In spite of attractive features such as simplicity of administration, oral immunotherapy has not been used for human allergy.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Allergen-Induced Airway Inflammation by Low-Dose Oral Immunotherapy with Transgenic Rice Seeds Independently of Immunoglobulin E Synthesis

Saeki

Nishimura²,

Kaminuma³

et al. 2012

Int Arch Allergy Immunol

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Background: Oral immunotherapy is potentially useful for the treatment of allergic diseases. We previously demonstrated that allergen-induced airway inflammation and immunoglobulin E (IgE) production in mice were suppressed by oral administration of high-dose transgenic (Tg) rice seeds (approximately 50 g/kg/day) expressing a T cell epitope of Dermatophagoides pteronyssinus group 1 allergen (Der p 1). However, this amount of Tg rice seeds was not realistic in our daily life. In this study, allergen-induced airway inflammation and IgE production following oral immunotherapy with a realistic (lowest) dose of Tg rice seeds were investigated. Methods: Mice orally administered with Tg or non-Tg rice seeds at approximately 5 g/kg/day for 1 week were immunized with recombinant Der p 1, and then challenged with the corresponding allergen. The infiltration of inflammatory cells into the airways and the levels of allergen-specific serum IgE were examined. Results: Low-dose oral administration of Tg rice seeds significantly inhibited the allergen-induced infiltration of eosinophils and lymphocytes into the airways, but allergen-specific IgE synthesis was not changed. Conclusions: Low-dose oral immunotherapy with Tg rice seeds could suppress allergen-induced airway inflammation through mechanisms other than the downregulation of IgE synthesis.

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Cost of allergy immunotherapy: sublingual vs subcutaneous administration

Seiberling

Hiebert

Nyirady

et al. 2012

Int Forum Allergy Rhinol

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The cost of SCIT varies dramatically according to insurance plan whereas the cost of SLIT varies between practices. When loss of productivity and travel expense are added into the cost of SCIT, SLIT might be comparable in cost and more convenient for the patient. Although the lack of insurance coverage for SLIT currently makes it more expensive than SCIT, we have found that the financial gap is much smaller than initially thought, especially when indirect costs and plans with less than 80% coverage or high weekly co-pay are factored into the equation.

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Sublingual immunotherapy: The optimism and the issues

Cited by 41 publications

References 61 publications

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

Inhibition of Allergen-Induced Airway Inflammation by Low-Dose Oral Immunotherapy with Transgenic Rice Seeds Independently of Immunoglobulin E Synthesis

Cost of allergy immunotherapy: sublingual vs subcutaneous administration

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