Submicrometer-resolution three-dimensional imaging with hard x-ray imaging microtomography

Takeuchi, Akihisa; Uesugi, Kentaro; Takano, Hidekazu; Suzuki, Yoshio

doi:10.1063/1.1515385

Cited by 54 publications

(39 citation statements)

References 18 publications

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“…DOEs can also be designed and implemented for other parts of the electromagnetic spectrum, such as x rays, etc. 42,43 Hence, DOEs can replace refractive optics in various applications. 44 In many optical setups with refractive optical elements, 45 some elements are paired without any relative motion between them.…”

Section: Discussionmentioning

confidence: 99%

Design and Fabrication of Diffractive Optical Elements with MATLAB

Anand¹,

Bhattacharya²

2017

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Section: Discussionmentioning

confidence: 99%

Design and Fabrication of Diffractive Optical Elements with MATLAB

Anand¹,

Bhattacharya²

2017

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“…For example, osteocyte lacunae are visible in tomographic images with 1.4 m spatial resolution (Peyrin et al, 1998). The development of higher spatial resolution is ongoing, and sub-micron tomography (0.6 m) has recently been achieved through the combination of CT and x-ray microscopy technology (Takeuchi et al, 2002). For commercially available CT scanners, resolutions of 30 to 15 m are typical (Borah et al, 2001), reflecting the range of resolutions commonly used for trabecular bone imaging.…”

Section: Application Of Ct Imaging To Cortical Bonementioning

confidence: 99%

Quantitative 3D analysis of the canal network in cortical bone by micro‐computed tomography

Cooper¹,

Turinsky²,

Sensen³

et al. 2003

The Anatomical Record Part B

175

155

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Cortical bone is perforated by an interconnected network of porous canals that facilitate the distribution of neurovascular structures throughout the cortex. This network is an integral component of cortical microstructure and, therefore, undergoes continual change throughout life as the cortex is remodeled. To date, the investigation of cortical microstructure, including the canal network, has largely been limited to the two-dimensional (2D) realm due to methodological hurdles. Thanks to continuing improvements in scan resolution, micro-computed tomography (muCT) is the first nondestructive imaging technology capable of resolving cortical canals. Like its application to trabecular bone, muCT provides an efficient means of quantifying aspects of 3D architecture of the canal network. Our aim here is to introduce the use of muCT for this application by providing examples, discussing some of the parameters that can be acquired, and relating these to research applications. Although several parameters developed for the analysis of trabecular microstructure are suitable for the analysis of cortical porosity, the algorithm used to estimate connectivity is not. We adapt existing algorithms based on skeletonization for this task. We believe that 3D analysis of the dimensions and architecture of the canal network will provide novel information relevant to many aspects of bone biology. For example, parameters related to the size, spacing, and volume of the canals may be particularly useful for investigation of the mechanical properties of bone. Alternatively, parameters describing the 3D architecture of the canal network, such as connectivity between the canals, may provide a means of evaluating cumulative remodeling related change.

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“…As mentioned above, the theoretical limit of the projection-type XMT is approximately 1 μ m, which is determined primarily by inevitable image blurring caused by Fresnel diffraction, the diffraction limit of visible light, and the spatial resolution of a scintillator. 10) Isotropic voxels (a volume element in 3D space) with 0.5 μ m edges, that were requisite to achieve the 1 μ m spatial resolution, were achieved in the reconstructed slices. In order to realize high-resolution imaging for ferrous materials, high photon energies of 40-70 keV were used in this study.…”

Section: X-ray Tomography Experimentsmentioning

confidence: 99%

High-resolution Observation of Steel Using X-ray Tomography Technique

et al. 2012

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A common, serviceable form of steel has been observed by employing synchrotron X-ray microtomography technique. Spatial resolution has been optimized using a test object with varying experimental conditions. Reasonably high resolution, which is close to the theoretical upper limit for the projection-type Xray tomography, has been achieved for a reasonably large specimen. Its application has made it possible to clearly observe a fatigue crack and its opening behavior in steel, and to demonstrate some quantitative mechanical evaluations.

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Submicrometer-resolution three-dimensional imaging with hard x-ray imaging microtomography

Cited by 54 publications

References 18 publications

Design and Fabrication of Diffractive Optical Elements with MATLAB

Design and Fabrication of Diffractive Optical Elements with MATLAB

Quantitative 3D analysis of the canal network in cortical bone by micro‐computed tomography

High-resolution Observation of Steel Using X-ray Tomography Technique

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