Submicron Scale‐Structured Hydrophilic Titanium Surfaces Promote Early Osteogenic Gene Response for Cell Adhesion and Cell Differentiation

Abstract

Our results revealed a strong synergistic effect between submicron-scale roughness and surface hydrophilicity on early osteogenic cell adhesion and maturation.

Multiwalled carbon nanotubes enhance human bone marrow mesenchymal stem cells’ spreading but delay their proliferation in the direction of differentiation acceleration

“…On tissue culture plastic (TCP) and smooth Ti surfaces cells preserved a rather immature, dividing osteogenic phenotype (high proliferation rates, low integrin levels, and low specific osteogenic cell differentiation). [13][14] This enhancement is additive, if not synergistic, with the introduction of surface nanoscale structures (PLLA nanofiber scaffolds, electrospun poly(e-caprolactone scaffolds). [15][16] Similar behavior of human mesenchymal stem cells has been observed on PLLA nanofiber scaffolds 17 or on electrospun poly(e-caprolactone) scaffolds.…”

Tratamento de superfície em implantes dentários: uma revisão de literatura

“…Os implantes que são tratados com jateamento de areia seguido de ataque ácido, sendo processados sob atmosfera de nitrogênio e armazenados em NaCl (cloreto de sódio) isotônico, são denominados SLActive. Esses implantes têm uma estabilidade secundária mais ativa que os demais implantes, sendo que essa ocorre em duas semanas após a instalação do implante no osso 25 . Nessa nova técnica, a superfície é hidroxilada, e essa mudança química melhora as estruturas superficiais, que são ideais para a adsorção de proteínas e para promover a intenção imediata do implante no tecido ósseo.…”

MWCNTs enhance hBMSCs spreading but delay their proliferation in the direction of differentiation acceleration

“…4,5 This enhancement is additive, if not synergistic, with the introduction of surface nanoscale structures. 6,7 Moreover, mesenchymal stem cells showed a reduced proliferation on BMP containing PLLA nanofiber scaffolds, with a diameter of 0.217 mm, accompanied by an increase in gene expression of ALP, OC and collagen-I 8 or on electrospun poly(e-caprolactone) scaffolds composed of aligned or cross-aligned fibers, with 1-1.2 mm diameter, in respect to TCP and flat substrate.…”