Substances isolated from Mandragora species

Hanŭs, L; Řezanka, Tomáš; Spížek, J.; Dembitsky, Valery M.

doi:10.1016/j.phytochem.2005.07.016

Cited by 43 publications

(25 citation statements)

References 28 publications

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“…Mandrake is known for its aphrodisiac, healing, hallucinogenic, and poisonous characteristics. Its fruits are also called love apples that were thought to increase fertility [90].…”

Section: Mandrakementioning

confidence: 99%

New psychoactive substances of natural origin: A brief review

Feng

Battulga

Han

et al. 2017

Journal of Food and Drug Analysis

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Plant-based drugs of abuse are as old as recorded human history. Although traditional addictive substances, such as opium, cannabis and coca, have been controlled by the United Nations anti-drug conventions, many, if not most, natural plants with addictive or abuse liability remain elusive. Therefore, the United Nations Office on Drugs and Crime (UNODC) has warned the emerging threat from new psychoactive substances (NPS), which are mostly derived or modified from the constituents of natural origin. For example, synthetic cannabinoids and synthetic cathinones are derived from the cannabis and khat plant, respectively. In this review, we briefly discussed the chemistry, pharmacology and toxicology of five common NPS of natural origin, i.e., khat, kratom, salvia, magic mushroom and mandrake. Through the review, we hope that professionals and general public alike can pay more attention to the potential problems caused by natural NPS, and suitable control measures will be taken.

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“…Mandrake is known for its aphrodisiac, healing, hallucinogenic, and poisonous characteristics. Its fruits are also called love apples that were thought to increase fertility [90].…”

Section: Mandrakementioning

confidence: 99%

New psychoactive substances of natural origin: A brief review

Feng

Battulga

Han

et al. 2017

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

show abstract

“…In fact, the popular name of this species is “Latue” (Mapuche language) or “Palo brujo” (Spanish name), which literally means “magical stick.” This species belonging to the Solanaceae family is related chemo-taxonomically to the European poisonous plants Atropa belladonna, Datura stramonium, Hyosciamus niger , and Mandragora spp. used in European and Asian countries since ancient times (Hanuš et al, 2005; Beyer et al, 2009). All mentioned species contain scopolamine and atropine as main alkaloids responsible for their pharmacological properties, including sedation, pain relief and psychoactive effects (Ramoutsaki et al, 2002; Beyer et al, 2009; Soni et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

High Resolution UHPLC-MS Metabolomics and Sedative-Anxiolytic Effects of Latua pubiflora: A Mystic Plant used by Mapuche Amerindians

et al. 2017

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Latua pubiflora (Griseb) Phil. Is a native shrub of the Solanaceae family that grows freely in southern Chile and is employed among Mapuche aboriginals to induce sedative effects and hallucinations in religious or medicine rituals since prehispanic times. In this work, the pentobarbital-induced sleeping test and the elevated plus maze test were employed to test the behavioral effects of extracts of this plant in mice. The psychopharmacological evaluation of L. pubiflora extracts in mice determined that both alkaloid-enriched as well as the non-alkaloid extracts produced an increase of sleeping time and alteration of motor activity in mice at 150 mg/Kg. The alkaloid extract exhibited anxiolytic effects in the elevated plus maze test, which was counteracted by flumazenil. In addition, the alkaloid extract from L. pubiflora decreased [3H]-flunitrazepam binding on rat cortical membranes. In this study we have identified 18 tropane alkaloids (peaks 1–4, 8–13, 15–18, 21, 23, 24, and 28), 8 phenolic acids and related compounds (peaks 5–7, 14, 19, 20, 22, and 29) and 7 flavonoids (peaks 25–27 and 30–33) in extracts of L. pubiflora by UHPLC-PDA-MS which are responsible for the biological activity. This study assessed for the first time the sedative-anxiolytic effects of L. pubiflora in rats besides the high resolution metabolomics analysis including the finding of pharmacologically important tropane alkaloids and glycosylated flavonoids.

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“…The alkaloid mandragorine was initially thought to be its active substance, but later it was found to be a mixture of hyoscyamine and scopolamine. All parts of Mandragora species (leaves, seeds, berries, and roots) are poisonous, as they all contain tropane alkaloids, basically hyoscyamine and scopolamine (3,4). Mandrake is the common name for different Mandragora species belonging to the family of Solanaceae (1,3).…”

Section: Introductionmentioning

confidence: 99%

“…All parts of Mandragora species (leaves, seeds, berries, and roots) are poisonous, as they all contain tropane alkaloids, basically hyoscyamine and scopolamine (3,4). Mandrake is the common name for different Mandragora species belonging to the family of Solanaceae (1,3). This plant dates back thousands of years and it was used in medicine as a narcotic before surgery, but also as an emetic and as antidote for snakebites (5).…”

Section: Introductionmentioning

confidence: 99%

“…This plant dates back thousands of years and it was used in medicine as a narcotic before surgery, but also as an emetic and as antidote for snakebites (5). Due to the ''human body'' shape of Mandrake's root ( Figure 1C) and its narcotic and poisonous effects, it was also known as magic, aphrodisiac, hallucinogenic, and is closely associated with witchcraft under the name of ''Devil's herb'' (2,3). The concept of this strange plant is surrounded with various myths and legends and recalls something mysterious, gloomy, and even horrible (6).…”

Section: Introductionmentioning

confidence: 99%

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