Substituted thiosemicarbazido/semicarbazido quinolines as possible antimalarials

Abstract

Several 2‐aryl substituted thiosemicarbazido‐4‐methyl‐6‐methoxyquinolines and 2‐aryl substituted semi‐carbazido 4‐methyl‐6‐methoxyquinolines were synthesized and evaluated for their antimalarial activity in mice infected with Plasmodium berghei. Two of these substituted quinolines were found to exhibit 50% clearance in a dose of 500 mg./kg. administered intraperitoneally for 5 days.

An Efficient New Route for the Synthesis of Some 3‐Hterocyclylquinolinones via Novel 3‐(1,2‐Dihydro‐4‐hydroxy‐1‐methyl‐2‐oxoquinolin‐3‐yl)‐3‐oxopropanal and Their Antioxidant Screening

“…Recently, quinolines were investigated as an important class of pharmaceutical active heterocyclic compounds which have been screened for their bactericidal , antifungal , antimalarial , antitumor , antileishmanial , and antioxidant activities . On the other hand, many of the pyrazolo, isoxazolo, pyridineo, pyrimidino, and benzodiazepino derivatives have been reported to exhibit antioxidant activity .…”

Reaction of 2-hydrazino-4-methyl-6-substituted quinolines with ethylacetoacetate: A structural reinvestigation

“…2-Hydrazino-4-methyl-6-substituted quinolines (1) were prepared following the literature procedure (Ports et al 1972;Mehrotra et al 1980;Vaid 1984).…”