Substoichiometric isotope dilution mass spectrometry as a new analytical method

Measurement of gold and sulfur mass fractions in l-cysteine-modified gold nanoparticles by ICP-DRC-MS after acid digestion: validation and uncertainty of results

“…However the use of isotopes also presents some problems, such as the mass discrimination correction for the accurate determination of isotope abundances or the use of very expensive enriched stable isotopes. 27 Hence external calibration without internal standard is often used to measure the concentration of S in DRC mode, [17][18][19] with a dynamic range of one order of magnitude and linear correlation coefficient of 0.997-0.999.…”

Substoichiometric Isotope Dilution Mass Spectrometry of Boron by the Ion-Pair Extraction with Halogenated Salicyl Alcohol Derivatives and a Quaternary Ammonium Salt

“…However, the difficulty of the accurate determination of the isotopic abundance of boron has been pointed out because of the interference from 12 C + 25,29,30 or the influence of co-existing ions like Na + 28 in the ICP-MS measurements. Substoichiometric isotope dilution mass spectrometry (SIDMS), which consists of substoichiometric separation of an element in question and only measurement of an proper isotope with a mass spectrometer, has several advantages, [31][32][33] i.e., (1) the quantitative recovery of the element is not required, (2) no calibration standards or curves are necessary, (3) measurement of isotopic abundance is not necessary, and (4) correction for the mass discrimination in the mass spectrometer is not necessary. Therefore, the analytical procedure in SIDMS is much more simple and rapid than that in general IDMS.…”