Successful Aging Among African American Older Adults With Type 2 Diabetes: Table 1.

Chard, Sarah; Harris-Wallace, Brandy; Roth, Erin G.; Girling, Laura; Rubinstein, Robert; Reese, Ashanté M.; Quinn, Charlene C.; Eckert, Jochen

doi:10.1093/geronb/gbw119

Cited by 19 publications

(15 citation statements)

References 46 publications

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“…Aging is a spontaneous and inevitable process in living organisms, which gradually show signs of decline in function, adaptability, and immunity. Aging is closely related to numerous diseases, including hypertension, type 2 diabetes, atherosclerosis, and senile dementia, which can be alleviated by delaying aging (Buford, 2016;Kitada et al, 2016;Chard et al, 2017). Currently, d-galactose is recognized as an aging-inducing agent, and aging animal models constructed using dgalactose are similar to the natural aging process.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose–induced oxidative aging in mice

Zhao

Zhou

et al. 2019

Journal of Dairy Science

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Yogurt from Xinjiang, China, is a traditional and naturally fermented food, and abundant microorganisms are produced during its fermentation process. In this study, we carried out in vivo animal experiments to explore the effect of a newly isolated lactic acid bacterial strain, Lactobacillus plantarum KSFY02 (LP-KSFY02), on oxidative aging. We used d-galactose to induce oxidative aging in mice and analyzed the serum and tissues of those mice using molecular biology detection methods. The results showed that LP-KSFY02 could inhibit the decreases in the thymic, cerebral, cardiac, liver, spleen, and kidney indices of mice caused by oxidative aging. The LP-KSFY02 strain increased activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione (GSH) and reduced levels of nitric oxide (NO) and malondialdehyde in the serum, liver, and spleen of the oxidative aging mice. Pathological observation demonstrated that LP-KSFY02 alleviated damage to the liver and spleen of oxidative aging mice. Quantitative PCR showed that LP-KSFY02 effectively upregulated mRNA expression of neuronal nitric oxide synthase (Nos1), endothelial nitric oxide synthase (Nos3), copper/zinc superoxide dismutase (Sod1), manganese superoxide dismutase (Sod2), catalase (Cat), heme oxygenase-1 (Hmox1), nuclear factor erythroid 2 related factor 2 (Nfe2l2), γ-glutamylcysteine synthetase (Gclm), and quinone oxidoreductase 1 (Nqo1) in mouse liver and spleen and downregulated expression of inducible nitric oxide synthase (Nos2). Western blot analysis revealed that LP-KSFY02 effectively upregulated protein expression of SOD1, SOD2, CAT, GSH1, and GSH2 in mouse liver and spleen tissues. Therefore, LP-KSFY02 can effectively prevent d-galactose-induced oxidative aging in mice. Its efficacy was superior to that of Lactobacillus delbrueckii ssp. bulgaricus (LDSB) and vitamin C, which are commonly used in the medical field as antioxidants. Thus, LP-KSFY02 is a high-quality strain with probiotic potential.

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Section: Introductionmentioning

confidence: 99%

Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose–induced oxidative aging in mice

Zhao

Zhou

et al. 2019

Journal of Dairy Science

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“…Aging is an inevitable biological process of growing older, which is accompanied by signs of decline in function, adaptability, and disease resistance of the body. Aging is an important risk factor for many diseases, including hypertension, type 2 diabetes, atherosclerosis, and senile dementia, whereas the onset of these diseases can be delayed by slowing down aging [ 12 , 13 , 14 ]. d -galactose is currently recognized as an aging-inducing agent that can induce aging in animal models, which is similar to the natural aging process, and thus has been widely used in the creation of animal models of aging.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum CQPC11 Isolated from Sichuan Pickled Cabbages Antagonizes d-galactose-Induced Oxidation and Aging in Mice

Qian

Zhang²,

Zhou

et al. 2018

Molecules

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Chinese pickled cabbage is a traditional fermented food that contains abundant microbes produced during the process of fermentation. In this work, an in vivo animal study was conducted to investigate the effects of a newly isolated lactic acid bacterium (Lactobacillus plantarum CQPC11, LP-CQPC11) on d-galactose-induced oxidation and aging in mice. Analysis of the serum and tissue samples of these mice using molecular biology approaches showed that LP-CQPC11 suppressed the decrease in thymus, brain, heart, liver, spleen, and kidney indices caused by oxidation and aging. Furthermore, LP-CQPC11 increased the levels of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase), and GSH (glutathione), whereas it reduced the levels of NO (nitric oxide) and MDA (malondialdehyde) in the serum, liver, and spleen of oxidation and aging mouse models. Pathological observation indicated that LP-CQPC11 alleviated the damage caused by oxidation and aging on the liver and spleen of mice. qPCR analysis indicated that LP-CQPC11 effectively upregulated the expression of nNOS (neuronal nitric oxide synthase), eNOS (endothelial nitric oxide synthase), Cu/Zn-SOD (cuprozinc-superoxide dismutase), Mn-SOD (manganese superoxide dismutase), CAT (catalase), HO-1 (heme oxygenase-1), Nrf2 (nuclear factor-erythroid 2 related factor 2), γ-GCS (γ-glutamylcysteine synthetase), and NQO1 (NAD(P)H dehydrogenase [quinone] 1), but downregulated the expression of iNOS (inducible nitric oxide synthase) in the mouse liver and spleen. Western blot analysis showed that LP-CQPC11 effectively upregulated SOD1 (Cu/Zn-SOD), SOD2 (Mn-SOD), CAT, GSH1 (c-glutamylcysteine synthetase), and GSH2 (glutathione synthetase) protein expression in mouse liver and spleen tissues. These findings suggest that LP-CQPC11 can effectively prevent d-galactose-induced oxidation and aging in mice, and the effect is even better than that of the commonly used Lactobacillus delbruechii subsp. bulgaricus (LDSB) and vitamin C in the industry. Thus, LP-CQPC11 may be potentially employed as a probiotic strain.

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“…To systematically explore over 4000 pages of narrative, data were formatted into ATLAS.ti ( 33 ), an organizational and analytical program that expedites evaluation of complex phenomenon in unstructured data. Analysis initiated with the development of an inductively derived codebook ( 27 ). First, the entire research team open-coded a selection of transcripts (n = 8; 2 AA men, 2 AA women, 2 NHW men, 2 NHW women) to identify a preliminary set of codes.…”

Section: Discussionmentioning

confidence: 99%

“…Data for this analysis were drawn from the Subjective Experience of Diabetes among Urban Older Adults (SED) study ( 27 ), a qualitative project exploring subjective understandings of diabetes among male and female African American (AA) and non-Hispanic whites (NHW). The community-dwelling sample was recruited through the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study ( 28 ).…”

Section: Methodsmentioning

confidence: 99%

Ascribed Meaning of Disease Control

Girling

Chard

Eckert

2017

Journal of Patient Experience

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Background:Contemporary treatment of type 2 diabetes mellitus (hereafter diabetes) heavily emphasizes “diabetes control,” largely defined by measurable blood glucose parameters. Little is known about how people living with the condition themselves define diabetes control within the lived experience of their disease.Methods:As part of a qualitative study investigating the subjective construction of diabetes, 83 in-depth interviews were conducted with African American and non-Hispanic white older adults. Using content analysis, 4237 pages of narrative data were analyzed to explore how informants conceptualized diabetes control.Findings:Four themes emerged from the data, describing varied understandings of diabetes control: (a) blood sugar regulation, (b) practicable treatment adherence, (c) bodily experience, and (d) degree of pharmaceutical need. Findings demonstrate that among persons with diabetes, the term diabetes control is multifaceted.Conclusion:While clinical guidelines have established target blood glucose parameters as the standard indicator of diabetes control, persons with diabetes conveyed varied and diverse meanings situated within personal experiences. To foster empathetic and collaborative care, health-care providers tending to this population may consider integrating the emergent themes into communicative and treatment approaches.

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Successful Aging Among African American Older Adults With Type 2 Diabetes: Table 1.

Abstract: Hardship and illness in participants' lives frame their diabetes experience and notions of well-being. Providers need to be aware of the social, economic, and political lenses shaping diabetes self-management and subjective well-being.

Cited by 19 publications

References 46 publications

Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose–induced oxidative aging in mice

Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose–induced oxidative aging in mice

Lactobacillus plantarum CQPC11 Isolated from Sichuan Pickled Cabbages Antagonizes d-galactose-Induced Oxidation and Aging in Mice

Ascribed Meaning of Disease Control

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