Successful management of aluminium phosphide poisoning using intravenous lipid emulsion: Report of two cases

Baruah, Udismita; Sahni, Ameeta; Sachdeva, Harish C

doi:10.4103/0972-5229.171412

Cited by 25 publications

(23 citation statements)

References 21 publications

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“…Though the observed improvement in survival of ALP poisoning did not reach a significant level, it could be considered a promising finding. In a previous two case reports; ILE administration had successfully resuscitated a severe case of ALP poisoning (Baruah et al, 2015).…”

Section: Discussionmentioning

confidence: 94%

“…According to Baruah et al (2015), the used regimen in this study was ILE 20% at a rate of 10 ml/h that gradually tapered with monitoring of serum triglyceride level. The total amount of ILE received by patients in the experimental group ranged from 100 to 1000 ml with a median amount of 300 ml.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the dose that has been successfully used by Baruah et al (2015) to resuscitate two cases of severe aluminium phosphide intoxication, ILE was administered in this group at a rate of 10 ml/h, IV infusion continue until improvement or death of the patient. Both the triglyceride level and the clinical condition of the patient guided monitoring of the ILE infusion.…”

Section: Experimental Groupmentioning

confidence: 99%

“…As regards ALP poisoning, ILE has been successfully used in resuscitation of two cases of suicidal poisoning with refractory hypotension as reported by Baruah et al (2015). This promising effect of ILE has gained great attention.…”

Section: Introductionmentioning

confidence: 99%

“…One gram phosphorus dissolves in 80 ml olive oil, 60 ml oil of turpentine, and about 100 mL of almond oil. So, PH3 might also have lipid soluble property and used IV lipid emulsion may counter its effects (Baruah et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Intravenous Lipid Emulsion as an Adjuvant Therapy in Acute Aluminum Phosphide Poisoning: A randomized Controlled Trial

ELabdeen

Saad

Oreby

et al. 2020

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Aluminum phosphide (ALP) is efficient rodenticide and insecticide. The increased incidence of acute ALP poisoning and its high mortality is a challenge for health professionals, there is no specific antidote and the treatment is mainly supportive. Aim of the work: The aim of this study was to evaluate the efficacy and safety of intravenous lipid emulsion as an adjuvant therapy for acute ALP poisoning. Patients and methods: The present study was carried out on fifty patients with acute ALP poisoning admitted at Poison Control Unit, Tanta University Emergency Hospital, throughout a period from the start of December 2016 till November 2017. The study participants were randomly allocated into 2 equal groups (25 patients each): The experimental group (received ILE 20% at a rate of 10ml/h IV infusion plus the conventional treatment of ALP poisoning), and the control group (received the conventional treatment only). Results: The number of deaths in the experimental group was lower than the control group, but it did not reach a significant level. The need for intubation and mechanical ventilation was significantly lower in the experimental group compared to the control group. Conclusion: The administration of ILE 20% in acute ALP poisoning at a rate of 10ml/h IV infusion is a safe therapy. Moreover, the adjuvant ILE use along with the conventional supportive treatment could have a therapeutic effect in ALP poisoned patients.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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