Successful Treatment of Adult Onset Langerhans Cell Histiocytosis with Bi-weekly Administration of Pegylated Interferon-α

Furudate, Sadanori; Fujimura, Taku; Kambayashi, Yahiko; Kawano, Mitsuko; Ogasawara, Kunio; Tsukada, Akira; Tamabuchi, Erika; Haga, Takahiro; Hashimoto, Akira; Aiba, Setsuya

doi:10.2340/00015555-1807

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Indeed, therapeutic management depends on the number of sites affected, the severity of the lesions, and the age of the patient. Many therapies have been tried such as chemotherapy, radiotherapy, or surgery [ 16 ]. For our patient, after relapse, the LCH protocol (vinblastine and high-dose methotrexate (MTX)) was chosen, and permits having a favorable response.…”

Section: Discussionmentioning

confidence: 99%

Unusual Cutaneous Location of Langheransian Histiocytosis: A Case Report

Bendari¹,

Chamizakhraji²,

Elamari³

et al. 2021

Cureus

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Langheransian cell histiocytosis (LCH) is a rare pathology characterized by the proliferation of CD1+ and Langerin+ cells. It can affect all ages, with an estimated prevalence of one to two cases/100,000 habitants. The involvement is often multi-visceral; however, isolated cutaneous involvement can be found in 40% of cases with very variable manifestations. We report the case of 45-year-old women followed for non-insulin-dependent diabetes and primary hyperparathyroidism suffering from isolated and refractory cutaneous histiocytosis.

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Section: Discussionmentioning

confidence: 99%

Unusual Cutaneous Location of Langheransian Histiocytosis: A Case Report

Bendari¹,

Chamizakhraji²,

Elamari³

et al. 2021

Cureus

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“…Chemotherapy, especially modest dose of ARA-C (100 mg/m 2 daily for 5 days, repeated monthly for 6) is suggested for disseminated LCH with multiple bone lesions or multisystem disease (Cantu et al 2012). Recent studies have been reported that administration of pegylated interferon-alpha can be helpful for treatment of LCH by inducing anti-tumoral response (Furudate et al 2014). A large fraction of LCH cases appear to be associated with BRAF mutations and those could potentially benefit from treatment with a BRAF inhibitor (Badalian-Very et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Langerhans cell histiocytosis in the adult lumbar spine: case report

et al. 2016

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IntroductionLangerhans cell histiocytosis (LCH) occurs rarely in the spine of adults. The radiological findings usually resemble vertebral tumors. Etiology of LCH has not been clearly established yet. Therapeutic approaches are still controversial. We describe a case of LCH in an adult spine.Case descriptionA patient who presented with low back pain had an osteolytic lesion in the L1 vertebral body without neurological deficits, and fluoroscopy-guided needle biopsy of the L1 vertebral body was performed. The immunohistochemical diagnosis confirmed LCH. The patient was successfully treated with conservative methods.DiscussionThe choice of appropriate therapy is very important, with treatment options varying from watch-and to aggressive treatment.ConclusionLCH is considered as a pediatric disease that is extremely rare in the spine of adults and should be include in the differential diagnosis of osteolytic vertebral lesions. Conservative treatment is best choice for a patient with LCH without neurological deficit or spinal instability.

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“…Notably, CD8 + cells contain various subpopulations of cytotoxic T cells, including granulysin-bearing cells. Granulysin has homology to other cytotoxic molecules of the saponin-like protein family [ 9 ] and lyses various tumors, which might be related to the prognosis of cancer patients and the self-regression of tumors [ 10 , 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

Terui¹,

Fujimura²,

Kakizaki³

et al. 2016

Case Rep Dermatol

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Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8⁺ cells and granulysin-bearing cells and lower numbers of CD206⁺ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.

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Successful Treatment of Adult Onset Langerhans Cell Histiocytosis with Bi-weekly Administration of Pegylated Interferon-α

Cited by 8 publications

References 10 publications

Unusual Cutaneous Location of Langheransian Histiocytosis: A Case Report

Unusual Cutaneous Location of Langheransian Histiocytosis: A Case Report

Langerhans cell histiocytosis in the adult lumbar spine: case report

Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

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