Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report

Zhao, Qian-Nan; Ma, Yuanyuan; Lu, Yuquan; Chai, Yi; Zhou, Yuemin

doi:10.1097/01.asw.0000604176.47082.60

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…However, in patients treated with hydrogel, a significant change was noted only at six weeks, indicating better granulation tissue formation with PRP. Clinically appreciable granulation tissue formation following treatment with PRP has been reported by various researchers [15,[22][23][24][25]. Back in 1986, Knighton et al demonstrated accelerated growth of granulation tissue and epithelization in chronic non-healing wounds following topical application of autologous platelet-derived wound healing factors [26].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Singh¹,

Borah²,

Khanna³

et al. 2021

Cureus

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Background: Pressure ulcer is one of the common complications occurring in spinal cord injury (SCI) patients. Platelet-rich plasma (PRP) has been found useful in the treatment of pressure ulcers in few studies. The purpose of this study was to evaluate the role of PRP in pressure ulcer healing in comparison to hydrogel dressing in SCI patients.Methods: In this randomized interventional study, 52 patients of SCI having pressure ulcers of grade III/IV were randomized into two groups of 26 each. In group A patients, hydrogel dressing was done while freshly prepared PRP was used in patients of group B. Pressure ulcers were evaluated at baseline and after three weeks and six weeks in terms of ulcer surface area, volume, Pressure Ulcer Scale for Healing (PUSH) score, histopathology, and ulcer healing parameters. Data were collected and quantitative variables were compared using unpaired t-test or Mann-Whitney test between the two groups and qualitative variables were compared using the chi-square test or Fisher's exact test. A p-value of <0.05 was considered statistically significant.Results: Baseline characteristics were comparable in both groups. There was a significant improvement in ulcers in terms of surface area, volume, and PUSH score in both the groups but it was comparable (p-value >0.05). There was a significant improvement in the PRP group as compared to the other group in terms of epithelization, granulation, and neovascularization at three and six-week follow-up.Conclusions: This study suggests that PRP is a possible and better alternative to conventional dressing methods for the treatment of pressure ulcers.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Singh¹,

Borah²,

Khanna³

et al. 2021

Cureus

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“…Among the other wounds treated (n = 10, 43.6%), infections developed a third of cases (n = 8, 34.8%) and the treatment was discontinued in two (8.7%). While our group has gained experience in the management of PRP obtained from donors since January 2012 [36], and in particular has used ABO-identical platelets from single healthy donors with promising results [31], we have only reported our work regarding their use for skin ulcers and secondary mandibular osteonecrosis at scientific meetings [36]. We emphasize that this current work with new recruited patients continues our previous studies and also the results are now consistent and support the previous results obtained.…”

Section: Discussionmentioning

confidence: 99%

Section: Use Of Al-prp Vs Au-prp In the Treatment Of Chronic Woundsmentioning

confidence: 99%

“…To our knowledge, Zhao et al [31] were the first to report successful treatment of hydroxyurea-related chronic lower extremity ulcers with single-donor al-PRP, in their case, using a donor with lineal consanguinity. They described a patient with ET treated with hydroxyurea whose clinical diagnosis was perplexing [31]. Both hypertension and thrombosis associated with ET and platelet count and blood pressure, which were well controlled during hydroxyurea administration, were ruled out as the main factors underlying the development of ulcers.…”

Section: Use Of Al-prp Vs Au-prp In the Treatment Of Chronic Woundsmentioning

confidence: 99%

“…This has motivated us to explore the reliability and safety of the effects of al-PRP. There has been relatively little research on this type of PRP beyond a few pilot and case studies in which it was found to have little immunogenicity and great healing efficacy in promoting tissue regeneration [29][30][31]. Specifically, to our knowledge, few data have been published on the use of al-PRP for CNHWs in general [32] or hard-to-heal DLEUs [33], in particular or concerning the safety and efficacy of al-PRP compared to those of au-PRP.…”

Section: Introductionmentioning

confidence: 99%

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Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study

Vidán-Estévez

Sánchez-Herraéz

Escalante

et al. 2021

JCM

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Chronic non-healing wounds (CNHWs) may be associated with trauma or idiopathic in nature and are difficult to treat. Our objective was to assess the use of platelet-derived growth factor (PDGF) from single-donor platelets (al-PRP), using one freeze-thaw cycle, for treating CNHWs. We conducted a cross-sectional study. A total of 23 CNHWs being treated with al-PRP. The al-PRP treatment can be considered successful in well over half (n = 13, 56.5%) of the wounds. We found that all the wounds treated for up to 7 weeks showed partial or complete healing, while those treated for between 8 and 12 weeks did not show healing, healing again being successful in cases in which treatment was extended to more than 13 weeks (85.7%). Using chi-square tests, this relationship was found to be highly significant (p < 0.001, chi2 = 19.51; p value = 0.00006). Notably, Cramer’s V coefficient was very high (0.921), indicating that the effect size of PRP treatment duration on healing is very large (84.8%). We could suggest that the use of al-PRP in the healing of CNHWs is a promising approach. Further studies with larger sample sizes and long follow-ups are needed to obtain multivariate models to explain which factors favour the healing of ulcers treated with PRP

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Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report

Cited by 6 publications

References 13 publications

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study

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