Successful Treatment of Long Standing Complex Regional Pain Syndrome with Hyperbaric Oxygen Therapy

Binkley, Karen; Katznelson, Rita

doi:10.1007/s11481-019-09901-x

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…e authors concluded that HBOT, even if initiated early after a traumatic extremity injury, did not confer any protection against the possibility to developing CRPS. Two case reports described potential benefits of HBOT in patients with chronic CRPS [37,38]. A 41-year-old male with a 1-year history of left-foot CRPS following ankle fracture demonstrated less pain, decreased swelling, less allodynia, improvement in skin color, and a range of motion of the lower limb after 3 weeks of HBOT [37].…”

Section: Role Of Hbot In Acute and Chronic Crpsmentioning

confidence: 99%

“…Furthermore, his mood and walking ability as well as interactions with other people and enjoyment of life markedly improved. Another case report [38] described a 50-year-old female with an 8-year complicated history of CRPS following the left fifth proximal phalanx fracture, in which multiple conventional and nonconventional therapies failed.…”

Section: Role Of Hbot In Acute and Chronic Crpsmentioning

confidence: 99%

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Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review

Schiavo

DeBacker

Djaiani

et al. 2021

Pain Research and Management

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Background. Chronic neuropathic pain is a condition affecting an increasing proportion of the general population and its management requires a comprehensive, multidisciplinary program. A growing body of evidence supports the use of hyperbaric oxygen therapy (HBOT) in several chronic neuropathic pain conditions; however, its role and efficacy remain unclear. Purpose. To summarize current evidence for the mechanistic rationale of HBOT in chronic neuropathic pain conditions and to evaluate its clinical efficacy. Methods. This narrative review was conducted after searching the following databases (Medline, Embase, Cochrane, PsycINFO, the Web of Science, Scopus, ClinicalTrials. gov, WHO ICTRP, and ProQuest Digital Dissertation) from January 1946 to March 2020. Articles published in English that involved either animal or human studies with acute or chronic neuropathic pain evaluating any HBOT-related intervention were included. Results. A total of 2971 citations were identified. A total of 29 studies were included in this review. The mechanisms of action for HBOT use in neuropathic conditions included the primary effects of hyperoxia and edema resolution, as well as the secondary effects pertinent to the production of oxygen and nitrogen reactive species (serving as pain signaling molecules), nitric oxide-dependent release of opioid peptides, and reduction of inflammatory mediators. A robust evidence for HBOT use in the clinical setting was associated with chronic regional pain syndrome and chronic primary bladder pain syndrome. Some evidence supported its use for chronic secondary (peripheral) neuropathic pain including radiation-induced plexus neuropathies, postherpetic neuralgia, and trigeminal neuralgia. Conclusions. HBOT has been shown to have antinociceptive and analgesic effects in animal models of inflammatory, neuropathic, and chronic pain. Human studies demonstrated beneficial effects of HBOT in improving clinical outcomes such as pain scores, pain-related symptoms, and quality of life. A systematic methodology of HBOT application is necessary to confirm its safety and efficacy.

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Section: Role Of Hbot In Acute and Chronic Crpsmentioning

confidence: 99%

Section: Role Of Hbot In Acute and Chronic Crpsmentioning

confidence: 99%

Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review

Schiavo

DeBacker

Djaiani

et al. 2021

Pain Research and Management

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“…In addition to a putative role in the acute recovery phase from direct ischemia,13 early reports suggest a potential for HBOT to feature in the treatment of other forms of ischemic nerve injury, such as chemotherapy-induced nerve injury or diabetic neuropathy 18 19. Our own HBOT program has previously reported on the application of HBOT for two adult patients with complex regional pain syndrome, both of whom experienced remarkable improvement in symptoms 20 21. However, the role for HBOT in the management of perioperative PNI has not been clearly elucidated.…”

Section: Introductionmentioning

confidence: 99%

The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature

Brenna

Khan

Katznelson

et al. 2022

Reg Anesth Pain Med

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Background/importancePeripheral nerve injury is an uncommon but potentially catastrophic complication of anesthesia and surgery, for which there are limited effective treatment options. Hyperbaric oxygen therapy is a unique medical intervention which improves tissue oxygen delivery and reduces ischemia via exposure to oxygen at supra-atmospheric partial pressures. While the application of hyperbaric oxygen therapy has been evidenced for other medical conditions involving relative tissue ischemia, its role in the management of peripheral nerve injury remains unclear.ObjectiveThis scoping review seeks to characterize rehabilitative outcomes when hyperbaric oxygen therapy is applied as an adjunct therapy in the treatment of perioperative peripheral nerve injury.Evidence reviewThe review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for scoping reviews, using a systematic screening and extraction process. The search included articles published from database inception until June 11, 2022, which reported clinical outcomes (in both human and non-human models) of peripheral nerve injury treated with hyperbaric oxygen therapy.FindingsA total of 51 studies were included in the narrative synthesis. These consisted of animal (40) and human studies (11) treating peripheral nerve injury due to various physiological insults. Hyperbaric oxygen therapy protocols were highly heterogenous and applied at both early and late intervals relative to the time of peripheral nerve injury. Overall, hyperbaric oxygen therapy was reported as beneficial in 88% (45/51) of included studies (82% of human studies and 90% of animal studies), improving nerve regeneration and/or time to recovery with no reported major adverse events.ConclusionsExisting data suggest that hyperbaric oxygen therapy is a promising intervention in the management of perioperative peripheral nerve injury, in which tissue ischemia is the most common underlying mechanism of injury, neurological deficits are severe, and treatment options are sparse. This positive signal should be further investigated in prospective randomized clinical trials.

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“…However, in most solid tumors, especially in microresidual tumors, the microcirculation of tumor blood vessels and the proliferation of tumors are prone to cause hypoxia. , The use of PDT will further deteriorate hypoxia through substantial consumption of oxygen and the closing effect of blood vessels, which greatly limit the therapeutic efficiency of PDT in the body. The traditional method of optimizing tumorous oxygen content is mainly through the introduction of low-frequency rays or hyperbaric oxygen inhalation. , Although these methods can effectively improve the hypoxic environment of tumor sites, they cannot reverse the tumor oxygen content during PDT and are prone to the potential toxicity of excessive oxygen, hampering their practical applications in the clinic . Perfluorinated compounds, which are demonstrated to be excellent oxygen carriers, can interact with oxygen and generate a physical adsorption effect .…”

Section: Introductionmentioning

confidence: 99%

“…The traditional method of optimizing tumorous oxygen content is mainly through the introduction of low-frequency rays or hyperbaric oxygen inhalation. 24,25 Although these methods can effectively improve the hypoxic environment of tumor sites, they cannot reverse the tumor oxygen content during PDT and are prone to the potential toxicity of excessive oxygen, hampering their practical applications in the clinic. 26 Perfluorinated compounds, which are demonstrated to be excellent oxygen carriers, can interact with oxygen and generate a physical adsorption effect.…”

Section: ■ Introductionmentioning

confidence: 99%

An Oxygen-Enriched Photodynamic Nanospray for Postsurgical Tumor Regression

Qin

Cao

et al. 2020

ACS Biomater. Sci. Eng.

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Postoperative local recurrence and metastasis are non-negligible challenges in clinical cancer treatment. Photodynamic therapy (PDT) has presented a great potential in preventing cancer recurrence owing to its noninvasiveness and high specificity for local irradiation of tumor sites. However, the application of conventional PDT is often limited by insufficient oxygen supply, making it difficult to achieve high PDT efficacy. Herein, we combined liposomes with photosensitizer indocyanine green (ICG) and perfluorooctyl bromide (PFOB) to develop a new oxygen-enriched photodynamic nanospray (Lip-PFOB-ICG) for cancer postoperative treatment. The Lip-PFOB-ICG not only has good biocompatibility but also enhanced the PDT effect under near-infrared light. More importantly, PFOB can continuously absorb oxygen, thus improving the collision energy transfer between the ICG photosensitizer and oxygen, and significantly inhibit local tumor recurrence in the subcutaneous tumor recurrence model. This oxygen-enriched photodynamic nanospray strategy may open up new avenues for effective postoperative cancer therapy in the clinic.

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Successful Treatment of Long Standing Complex Regional Pain Syndrome with Hyperbaric Oxygen Therapy

Cited by 12 publications

References 26 publications

Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review

Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review

The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature

An Oxygen-Enriched Photodynamic Nanospray for Postsurgical Tumor Regression

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