Successful treatment of pityriasis lichenoides with topical tacrolimus

Simon, Dagmar; Boudny, Clara; Nievergelt, Helga; Simon, Hans‐Uwe; Lr, Braathen

doi:10.1111/j.1365-2133.2004.05920.x

Cited by 34 publications

(19 citation statements)

References 9 publications

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“…Simon et al reported complete clearance in 2 patients with PLC who underwent treatment with 0.03% ointment twice daily for 14 and 18 weeks, respectively. 111 Mallipeddi and Evans also reported the successful use of twice-daily tacrolimus 0.1% ointment in a patient with refractory PLC. 112…”

Section: Topical Agentsmentioning

confidence: 95%

Pityriasis lichenoides and its subtypes

Bowers

Warshaw

2006

Journal of the American Academy of Dermatology

201

284

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Section: Topical Agentsmentioning

confidence: 95%

Pityriasis lichenoides and its subtypes

Bowers

Warshaw

2006

Journal of the American Academy of Dermatology

201

284

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“…Data are scarce and limited to case reports. Simon et al . treated only two paediatric patients affected by PLEVA and not responding to topical corticosteroids or UVB phototherapy with tacrolimus 0.03% ointment twice daily.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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“…Topical corticosteroids and antihistamines are helpful in symptomatic cases, but they do not alter the course of the disease. Recently, good responses with topical tacrolimus treatment were reported [9]. Current knowledge about the efficacy of phototherapy for PL is limited and is mostly based on anecdotal reports and small-scale studies [10].…”

Section: Discussionmentioning

confidence: 99%

Pityriasis Lichenoides et Varioliformis Acuta: Case Report and Review of the Literature

et al. 2012

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We report a case of a 63-year-old man hospitalized for a polymorphous generalized eruption consisting of maculopapules with peripheral scaling, vesicopustules, and ulceronecrotic and crusted lesions measuring 5–20 mm, localized on his trunk and extremities, particularly exuberant in the flexural area. Histopathology showed necrotic keratinocytes with exocytosis of red blood cells and lymphocytes and a dermal perivascular and periadnexal inflammatory infiltrate, composed of CD8+/CD4–/CD30– T cells, indicating the clinical diagnosis of pityriasis lichenoides et varioliformis acuta. He was treated with erythromycin and methylprednisolone reduced gradually over 5 months, with a slow but complete response; the patient was without lesions after 2 years of follow-up. The authors want to remind of this rare entity which may present difficulties in diagnosis and therapy.

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Successful treatment of pityriasis lichenoides with topical tacrolimus

Cited by 34 publications

References 9 publications

Pityriasis lichenoides and its subtypes

Pityriasis lichenoides and its subtypes

A systematic review of treatments for pityriasis lichenoides

Pityriasis Lichenoides et Varioliformis Acuta: Case Report and Review of the Literature

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