Sufentanil postoperative analgesia reduce the increase of T helper 17 (Th17) cells and FoxP3+ regulatory T (Treg) cells in rat hepatocellular carcinoma surgical model: A randomised animal study

Peng, Yanhua; Yang, Jinfeng; Guo, Duo; Zheng, Chumei; Sun, Hao; Zhang, Qinya; Zou, Shuangfa; Zhang, Yanping; Luo, Ke; Candiotti, Keith A.

doi:10.1186/s12871-020-01129-0

Cited by 14 publications

(10 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 27 Moreover, sufentanil may decrease the CD4 + /CD8 + ratio and increase the frequency of Treg cells. 28 , 29 Treg cells in the breast cancer were positively associated with disease progression, and the CD8+/Treg ratio was associated with lymph node metastasis and tumor staging. 31 Treg cells are considered immuno-suppressive cells, similar to Th2 cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Hu¹,

Liu²,

Wu³

et al. 2021

DDDT

View full text Add to dashboard Cite

Background: It is very important for breast cancer patients undergoing surgery to choose an opioid that has little effect on the immune system. The aim of this study is to compare the effects of dezocine or sufentanil on postoperative pain and Th1/Th2 balance in patients undergoing breast cancer surgery. Methods: Data from 92 breast cancer patients from January 2019 to July 2020 at Foshan Second People's Hospital (Guangdong, China) were analyzed. Sufentanil (SF) was used in group SF (n = 44) and dezocine (DE) in group DE (n = 48). The Visual Analog Scale (VAS) scores were assessed, and the percentages of Th1 cells and Th2 cells in peripheral blood were detected before anesthesia and at 2, 12, 24, and 48 hours after surgery. Results: There was no significant difference in the VAS scores between the two groups at 2, 24, and 48 hours after surgery (P > 0.05). The VAS scores at 12 hours after surgery in group DE were significantly lower than those in group SF with a statistically significant difference (P < 0.05). The percentage of Th1 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The percentage of Th2 cells in group DE at 2, 12, 24, and 48 hours after surgery was significantly lower than that in group SF (P < 0.05). The Th1/Th2 ratio at 2, 12, 24, and 48 hours after surgery was significantly higher in group DE than that in group SF (P < 0.05). Conclusion: Dezocine for anesthesia induction and postoperative analgesia can maintain the balance of Th1/Th2 more stable than, with the same analgesia efficacy as, sufentanil during the early postoperative period in breast cancer patients undergoing surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Hu¹,

Liu²,

Wu³

et al. 2021

DDDT

View full text Add to dashboard Cite

show abstract

“…In line with these findings, heroin users show reduced CD4 + T cell proliferative activity upon stimulation in vitro and an altered Th1/Th2 balance when compared with healthy controls and individuals on opioid maintenance therapy (Sacerdote et al, 2008;Riß et al, 2012). In rats, acute morphine exposure (Peng et al, 2020) and moderate doses of naltrexone (Xu et al, 2020) have been shown to suppress Th17 cell expression and function, as well as disrupt the balance between Th1 and Th2 cells (Xu et al, 2020). Moreover, treatment with chronic morphine enhances Th17 cell functional activity in peripheral blood mononuclear cells isolated from non-human primates (Cornwell et al, 2013).…”

Section: Clinical Use Of Opioids and Immunomodulationmentioning

confidence: 87%

Multiple Sclerosis and the Endogenous Opioid System

et al. 2021

View full text Add to dashboard Cite

Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, neuronal degeneration and demyelinating lesions within the central nervous system. The mechanisms that underlie the pathogenesis and progression of MS are not fully known and current therapies have limited efficacy. Preclinical investigations using the murine experimental autoimmune encephalomyelitis (EAE) model of MS, as well as clinical observations in patients with MS, provide converging lines of evidence implicating the endogenous opioid system in the pathogenesis of this disease. In recent years, it has become increasingly clear that endogenous opioid peptides, binding μ- (MOR), κ- (KOR) and δ-opioid receptors (DOR), function as immunomodulatory molecules within both the immune and nervous systems. The endogenous opioid system is also well known to play a role in the development of chronic pain and negative affect, both of which are common comorbidities in MS. As such, dysregulation of the opioid system may be a mechanism that contributes to the pathogenesis of MS and associated symptoms. Here, we review the evidence for a connection between the endogenous opioid system and MS. We further explore the mechanisms by which opioidergic signaling might contribute to the pathophysiology and symptomatology of MS.

show abstract

“…Altered Treg cell numbers have been reported in tobacco use related diseases including increased Treg cell numbers in pulmonary lymphocyte follicles of moderate COPD patients ( 8 ), increased Foxp3 + Treg cells in large airways but decreased in small airways (main pathological sites in COPD) ( 9 , 10 ), and decreased Treg cell numbers in the blood of patients with severe COPD ( 13 ), suggesting that the chronic inflammation in these patients may be promoted by lack of this regulatory cell population. In addition, studies revealed that M use alters T cell compartmentation and function, including the Treg cell component ( 20 , 42 ). Our study observed that both SM and M alone increased the proportion of Treg cells in spleen, and SM increased the percentage of Treg cells in LN.…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4+ Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome

Shao

Cornwell

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

There is a high incidence of tobacco use among intravenous opioid drug users. It is well established that opioids and tobacco smoke induce a degree of immune activation, and recent work suggests that the combination of these drugs promotes further activation of the immune system. Our approach involved the treatment of wild-type mice with cigarette smoke (SM) for a period of eight weeks, and the chronic continuous administration of morphine (M) via mini-pumps for the final four weeks. In an effort to examine the responses of CD4+CD25highCD127low regulatory T (Treg) cells, the major immune suppressive cell type, to the combined chronic administration of SM and M, we determined the frequency of these cells in the spleen, lymph nodes and lungs. Flow cytometric analyses showed that SM and M individually, and the combination (SM + M) have differential effects on the numbers of Treg in the spleen, lymph node, and lung. Either SM or M alone increased Treg cell numbers in the spleen, but SM+M did not. Furthermore, SM + M decreased Treg cell numbers in the lymph node and lung. We then performed RNA-Seq on Treg cells from mice treated with SM, M, or SM + M, and we found that the S + M induced a number of significant changes in the transcriptome, that were not as apparent following treatment with either SM or M alone. This included an activation of TWEAK, PI3K/AKT and OXPHOS pathways and a shift to Th17 immunity. Our results have provided novel insights on tissue Treg cell changes, which we suggest are the result of transcriptomic reprogramming induced by SM, M, and SM + M, respectively. We believe these results may lead to the identification of novel therapeutic targets for suppressing smoke and opioid induced Treg cell impairment.

show abstract

Sufentanil postoperative analgesia reduce the increase of T helper 17 (Th17) cells and FoxP3+ regulatory T (Treg) cells in rat hepatocellular carcinoma surgical model: A randomised animal study

Cited by 14 publications

References 38 publications

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery

Multiple Sclerosis and the Endogenous Opioid System

Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4+ Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome

Contact Info

Product

Resources

About