Suicide and Alzheimer Disease

Vega, Ursula; Kishikawa, Yusuke; Ricanati, Elisabeth; Friedland, Robert P.

doi:10.1097/00019442-200207000-00021

Cited by 19 publications

(10 citation statements)

References 4 publications

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“…Our findings are supported by a growing body of researches on suicidality in patients with dementia, reporting that young age is a risk factor for suicide behavior. 9,11 Intriguingly, no association between gender and risk of suicide was found in our patients. This finding is in line with other research focused on suicide behavior in patients with neurodegenerative disorders, that did not confirm a higher tendency of suicidality in females.…”

Section: Discussioncontrasting

confidence: 65%

“…6 -8 However, a growing body of research suggests that mood changes, severity of cognitive impairment, and awareness of disease may lead patients with different forms of dementia to be more vulnerable to suicidal behavior. 8 -12 To date, literature is scarce about the suicide risk in patients with bvFTD. In 2012, a first case report described a patient with bvFTD who committed suicide a few months after the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Zucca

Rubino

Vacca

et al. 2018

Am J Alzheimers Dis Other Demen

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Background: Recent studies reported an increased risk of suicidality in behavioral variant Frontotemporal Dementia (bvFTD). Aim of the study was to determine the prevalence of suicidal ideation and attempts in bvFTD patients, evaluating possible risk factors for suicidality. Methods: Risk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 bvFTD patients and 25 controls. Results: According to SSI, 40% of bvFTD patients had suicidal ideation in comparison to 8% of controls (p=.009). Four bvFTD patients have attempted suicide versus none control (p=.006). BvFTD patients with suicide risk showed higher levels of anxiety, depression, stress and hopelessness than patients without suicide risk (p<.001). Patients who attempted suicide were younger, and had a longer disease duration than those with only suicide ideation. Intriguingly, 40% of patients with parkinsonism presented high level of suicide ideation. Conclusions: Our findings show that bvFTD patients have a high risk of suicide. Additional studies in larger population are needed to confirm our results.

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Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Zucca

Rubino

Vacca

et al. 2018

Am J Alzheimers Dis Other Demen

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“…69 In addiction, 5-hydroxyindoleacetic acid in the prefrontal cortex has been associated with inhibition disorders resulting in aggressive or impulsive behavior. 70 Empirical data on suicide in dementia are scarce and primarily based on anecdotal case reports [70][71][72] in which the individuals, congruent with the clinical profile seen in elderly suicides, used lethal means and gave few indications of suicidal intent. 73 Although cognitive impairment could result in a diminishing ability to think flexibly and to solve problems or to cope with conflict, in the early stage of dementia such impairments are absent or mild and suicidal behavior might be expected, especially after diagnosis.…”

Section: Homicide Suicide and Homicide-suicidementioning

confidence: 99%

Violent and criminal manifestations in dementia patients

Cipriani

Lucetti

Danti

et al. 2015

Geriatrics Gerontology Int

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Although the older adults have been studied as victims of violence, geriatric patients can display violent behavior. The purpose of the present review was to explore the phenomenon of criminal violations and violent acts in people with dementia. The authors used PubMed to search the MEDLINE database and other sources for original research and review articles on criminal and violent manifestation in demented patients combining the terms "criminal manifestation," "violence, aggressive behavior," "homicide," "suicide" and "homicide-suicide" together with "dementia". Possible biomarkers of violence are considered. The present review highlights the risk factors for violence in patients suffering from dementia, and reviews the literature about criminal violations and homicidal/suicidal behavior in this patient group. Geriatr Gerontol Int 2016; 16: 541-549.

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“…Case 1: in the USA 6 An 84-year-old retired engineer-industrialist, who had been enjoying his personal life after early retirement in his fifties from the company he founded, developed memory impairment in 1989 followed, within a year, by language problems and depression. Clinical examination in May 1990 disclosed moderately impaired memory functions, difficulty with calculations, constructions, word finding, naming, repetition and clock drawing.…”

Section: Case Reportmentioning

confidence: 99%

“…Depression is often considered as the possible cause of these tragic events. 5,6 Although depression in AD is common, suicide occurs only rarely in the disorder. Factors causing depression in AD patients have been discussed from various viewpoints, such as decreased noradrenergic and serotonergic activity in cortex, 7,8 psychological problems associated with cognitive impairment and socio-psychological factors accompanied by maladjustment to their environment.…”

Section: Introductionmentioning

confidence: 99%

Socio‐psychological factors in suicide with Alzheimer’s disease: comparative case studies of two patients in the USA and Japan

Kishikawa¹,

Friedland²,

Ueda³

et al. 2007

Psychogeriatrics

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The objective of this case report is to illustrate the influence of sociopsychological background on behavior in patients with Alzheimer's disease (AD). A comparative analysis was undertaken of two suicide cases with AD in the USA and Japan. Both cases were in the early stages of AD. They succeeded in suicide even with their disturbed executive functions, because they felt deprived of their dignity for different reasons according to their socio-cultural background. Early stage AD patients may retain the behavior and intellectual functions associated with their dignity and desire. Since dignity and desire are very cultural concerns, socio-psychological background should be cautiously considered when dealing with the emotional problems of AD patients.

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Suicide and Alzheimer Disease

Cited by 19 publications

References 4 publications

High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Violent and criminal manifestations in dementia patients

Socio‐psychological factors in suicide with Alzheimer’s disease: comparative case studies of two patients in the USA and Japan

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