Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

Abstract

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = −0.097, p = 0.016) in men, and with body mass index (β = −0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = −0.059, p = 0.039), and bone trabecular area ratio (β = −0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.

Serum Bone Resorption Markers after Parathyroidectomy for Renal Hyperparathyroidism: Correlation Analyses for the Cross-Linked N-telopeptide of Collagen I and Tartrate-Resistant Acid Phosphatase

“…TRAP activity is increased in patients with chronic renal failure and in uremic patients with SHPT [33]. Decreases in serum TRAP reflect decreases in osteoclast activity, and serum TRAP is independently correlated with decreased bone mineral density [34]. Furthermore, pre-PTX serum TRAP values have been found to be predictive of bone mineral densities for the femoral neck and lumbar spine at 1-year following PTX [35].…”

Osteoporosis and the Potential of Cell-Based Therapeutic Strategies

“…It presents low diurnal variability and is not affected by feeding [50], being typically increased in high bone turnover conditions [51]. There are specific immunoassays for serum TRACP5b detection, actually it has been proposed for the evaluation of BMD in women [52].…”

Biochemical Markers of Bone Resorption and Hormonal Regulation of Bone Metabolism Following Liver Transplantation

“…Вместе с тем имеются данные, что при патологических условиях в печени акти-визируются процессы отложения неспецифиче-ских фибриллярных коллагенов 1, 3 и 5-го типов [18,33], и следовательно, деградация некостного коллагена может явиться причиной завышенной оценки деградации костного коллагена 1-го типа, в частности бета-изомера С-терминального тело-пептида коллагена 1-го типа (бета-кросслапсов). В последнее время появились работы о высокой прогностической значимости сывороточной кост-ной фракции 5б тартрат-резистентной кислой фос-фатазы (КТРКФ-5б) -маркера остеокластической активности, который имеет низкую дневную ва-риабельность и не накапливается в циркулирую-щей крови в случае почечной или печеночной па-тологии [23]. Однако в доступной нам литературе данных о сравнительном анализе двух маркеров резорбции бета-кросслапсов (БКЛ) и КТРКФ-5б у реципиентов после трансплантации печени нами не обнаружено.…”