Sulfated heterorhamnans from the green seaweed Gayralia oxysperma: partial depolymerization, chemical structure and antitumor activity

Ulvans induce resistance against plant pathogenic fungi independently of their sulfation degree

“…Additionally, SU3 and SU5 spectra presented C-1 (groups of signals centered at 98.6, 98.3 and 97.3 ppm) and C-3 (∼77.6 ppm) of the 4-linked 2,3-disulfate rhamnosyl units upfield shifted (␤-effect) when compared to C-1 (101.0, 99.3 and 98.9 ppm) and C-3 (79.4, 79.6 ppm) of the 4-linked 3-sulfate rhamnosyl units. This C-2 downfield shift (␣-shift) of +6.5-7.2 ppm after C-2 sulfation, as well as C-1 and C-3 upfield shift are in good agreement with the effect promoted by sulfate groups at C-2 of the 3-linked rhamnosyl units of sulfated heterorhamnans obtained from Gayralia oxysperma (Ropellato et al, 2015).…”

Transcriptome Profiling Reveals the Antitumor Mechanism of Polysaccharide from Marine Algae Gracilariopsis lemaneiformis

“…There is a current tendency in the field of bioactive natural products with research applications toward a focus on marine organisms [ 20 , 21 ]. More recently, compounds originating from marine algae have been found to be associated with numerous health-promoting effects, including anti-oxidative, anti-inflammatory, antiviral, antimicrobial, and antitumor effects, in particular [ 22 , 23 ]. Polysaccharides of marine origin, constituting one type of these biochemical compounds, have proven to possess several important properties, such as immunomodulatory, antitumor and cancer preventive, hypoglycemic, anti-inflammatory, and antioxidant activities, making them promising bioactive products and biomaterials with a wide range of applications [ 4 , 20 ].…”

Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

“…RS has been reported to have biological activities such as antiviral [6,[9][10][11][12][13], anticoagulant [14][15][16][17][18][19][20][21], and antitumor [22] activities. It also induces hyaluronidase inhibition [23], exhibits anti-hypercholesterolemic effect [24,25] suppresses blood glucose elevation [26], and helps with weight control [25]; thus, M. nitidum-derived RS is considered to be involved in many activities in host defense of humans.…”

“…Anti-hyaluronidase in vitro study [23] Antitumor in vitro study [22] Anti-obesity in vivo study [25] Anti-thrombosis in vitro study [14][15][16][17][18][19][20][21], in vivo study [16,17] Antivirus in vitro study [6,[9][10][11]13], in vivo study [12,13] Anti-hypercholesterolemia in vivo study [25], human trial [24] Anti-hyperglycemia in vivo study [26], human trial [26] In what follows, we describe some of the biological activities of M. nitidum-derived RS that we have studied and reported, especially its antiviral, anti-obesity, anti-hypercholesterolemic, anti-glycemia, antithrombotic, and anti-inflammation effects.…”