Sulfur-Containing Compounds from Clinacanthus siamensis

Tuntiwachwuttikul, Pittaya; Pootaeng‐on, Yupa; Pansa, Pootchana; Srisanpang, Thongchai; Taylor, Walter C.

doi:10.1248/cpb.51.1423

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…Four new compounds 1 – 4 and three known compounds, entadamide A ( 5 ) [5], entadamide C [6], and trans -3-methylsulfinyl-2-propenol [7] were isolated from the ethanolic extract of the aerial parts of C. nutans . The known compounds were identified by comparison of their physical and spectroscopic data to those reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

“…The IR spectrum showed strong absorption bands at 3380 cm −1 (OH), 1668 cm −1 (NH–C=O), 1555 cm −1 (C=C), and 1302 and 1135 cm −1 (O=S=O). The 1 H-NMR data of 1 (Table 1) exhibited one methylsulfonyl signal [δ H 3.08 (s)] [7], two methylene signals [δ H 3.41 (t, J = 5.7 Hz) and 3.65 (t, J = 5.7 Hz)], and a trans -disubstituted double bond [δ H 7.01 (d, J = 15.0 Hz)] and 7.43 (d, J = 15.0 Hz)]. The 13 C-NMR (Table 2), DEPT and HSQC spectra of 1 showed six carbon signals, consisting of one methylsulfonyl group (δ C 42.4), one oxymethylene group (δ C 61.2), one methylene group (δ C 43.4), one disubstituted olefin group (δ C 136.3 and 140.1), and one amide carbonyl group (δ C 164.6).…”

Section: Resultsmentioning

confidence: 99%

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Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Liu

Cheng

et al. 2014

Molecules

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Four new sulfur-containing compounds, named clinamides A-C (1-3), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Liu

Cheng

et al. 2014

Molecules

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“…Other members of the Acanthaceae family, such as Andrographis paniculata, Hypoestes rosea and Clinacanths siamensis, contain terpenes and xanthones with antiplasmodial activity (Tuntiwachwuttikul et al, 2003;Ojo-Amaize et al, 2007;Mishra et al, 2009). Thus, compounds with antiplasmodial activity found in Acanthaceae might also be present in Adhatoda latibracteata.…”

Section: Adhatoda Latibracteatamentioning

confidence: 99%

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Lékana-Douki

Bongui

Liabagui

et al. 2011

Journal of Ethnopharmacology

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“…Clinacanthus nutans Lindau is a medicinal plant from Acantheceae family widely distributed throughout tropical Asia. For a long time, this shrub has been used to prevent skin infections, insect bites and lesions caused by the herpes simplex and varicella-zoster viruses [ 18 , 19 ]. Many beneficial effects of this plant have been reported, including antidiabetic, antioxidant, anti-proliferative, immunomodulatory, wound healing, anti-inflammatory, analgesic activities and anti-viral activities [ 20 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and, α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans

Alam

Zaidul

Ghafoor

et al. 2017

BMC Complement Altern Med

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BackgroundThis study was aimed to evaluate antioxidant and α-glucosidase inhibitory activity, with a subsequent analysis of total phenolic and total flavonoid content of methanol extract and its derived fractions from Clinacanthus nutans accompanied by comprehensive phytochemical profiling.MethodsLiquid-liquid partition chromatography was used to separate methanolic extract to get hexane, ethyl acetate, butanol and residual aqueous fractions. The total antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging and ferric reducing antioxidant power assay (FRAP). The antidiabetic activity of methanol extract and its consequent fractions were examined by α-glucosidase inhibitory bioassay. The chemical profiling was carried out by gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC Q-TOF MS).ResultsThe total yield for methanol extraction was (12.63 ± 0.98) % (w/w) and highest fractionated value found for residual aqueous (52.25 ± 1.01) % (w/w) as compared to the other fractions. Significant DPPH free radical scavenging activity was found for methanolic extract (63.07 ± 0.11) % and (79.98 ± 0.31) % for ethyl acetate fraction among all the fractions evaluated. Methanol extract was the most prominent in case of FRAP (141.89 ± 0.87 μg AAE/g) whereas most effective reducing power observed in ethyl acetate fraction (133.6 ± 0.2987 μg AAE/g). The results also indicated a substantial α-glucosidase inhibitory activity for butanol fraction (72.16 ± 1.0) % and ethyl acetate fraction (70.76 ± 0.49) %. The statistical analysis revealed that total phenolic and total flavonoid content of the samples had the significant (p < 0.05) impact on DPPH free radical scavenging and α-glucosidase inhibitory activity.ConclusionCurrent results proposed the therapeutic potential of Clinacanthus nutans, especially ethyl acetate and butanol fraction as chemotherapeutic agent against oxidative related cellular damages and control the postprandial hyperglycemia. The phytochemical investigation showed the existence of active constituents in Clinacanthus nutans extract and fractions.

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Sulfur-Containing Compounds from Clinacanthus siamensis

Cited by 16 publications

References 12 publications

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

In vitro antioxidant and, α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans

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