SULT1A1 Arg213His Polymorphism and Lung Cancer Risk: a Meta-analysis

Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Lung Cancer: an Updated Meta-analysis

“…Therefore, effects toward primary prevention in addition to early detection have come under the spotlight. On the one hand, several metaanalyses involving associations between LC risk and gene polymorphisms have been published: SULT1A1 Arg213His polymorphism and LC (Liao et al, 2012); cyclooxygenase 8473 T/C polymorphism and LC (Pan et al, 2011); hOGG1 Ser326Cys polymorphism and LC (Guan et al, 2011). On the other hand, epidemiologic studies have provided evidence that high consumption of vegetable and fruits are associated with a reduced risk of LC, and dietary folate may be one of the micronutrients that provide protection against lung carcinogenesis (Bandera et al, 1997;Voorrips et al, 2000;Shen et al, 2003).…”

Sulfotransferase genetic variation: from cancer risk to treatment response

“…SULT1A1 genetic variability seems to show fairly consistent results as a significant risk factor for lung cancer (Table 4). However, a recent meta-analysis that included a total of five publications covering 1669 cases and 1890 controls (Liao et al, 2012) found no overall association between SULT1A1*1 and lung cancer risk in all genetic models (dominant model: OR = 1.33, 95% CI = 1.00–1.76, p = 0.05; additive model: OR = 1.30, 95% CI = 0.93–1.81, p = 0.12; recessive model: OR = 1.21, 95% CI = 0.89–1.66, p = 0.23). Subgroup analysis revealed an elevated risk in mixed populations with SULT1A1*2 in the dominant model (OR = 1.66, 95% CI = 1.06–2.62, p = 0.03) and an increased risk of lung cancer in both females and males in the dominant model (females: OR = 1.72, 95% CI = 1.29–2.27, p = 0.001; males: OR = 1.46, 95% CI = 1.19–1.78, p =0.00).…”

Folate Pathway Gene MTHFR C677T Polymorphism and Risk of Lung Cancer in Asian Populations

“…Meta-analysis is a powerful tool for analyzing cumulative data of studies where the individual sample sizes are small and the statistical power low (Guan et al, 2011;Rai, 2011;2014;Liao et al, 2012;Yadav et al, 2014). Several meta-analyses were published to assess the role of MTHFR polymorphism in cancer development like: breast cancer (Liang et al, 2013), lung cancer (Boccia et al, 2009;Pan et al, 2011), colorectal cancer (Hubner and Houlston, 2007), pancreatic cancer (Tu et al, 2012), esophageal cancer (Liu et al, 2011), and cervical cancer (Mei et al, 2012).…”