Summary of a workshop on n−3 fatty acids: current status of recommendations and future directions

Akabas, S. R.; Deckelbaum, Richard J.

doi:10.1093/ajcn/83.6.1536s

Cited by 60 publications

(37 citation statements)

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“…Conversely, it could be a concern in subjects with a hemorrhagic predisposition, under anti-thrombotic therapy or undergoing surgical interventions. Others have identified an urgent need for more extensive dose-response studies to assess the association between different doses of ALA and bleeding times (Akabas and Deckelbaum, 2006).…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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Background: Dietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet. Objective: To investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of a-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil. Results: All subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues. Conclusion: Subject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseedsupplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation.

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Section: Discussionmentioning

confidence: 99%

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

et al. 2009

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“…Their study's investigation of both deficient and excess ω-3 fatty acids consumption during pregnancy and lactation has important health implications. Current United States consumption of ω-3 fatty acids is lower than national and international recommendations (Akabas and Deckelbaum 2006) and excess ω-3 fatty acids is being consumed voluntarily (Rump and others 2001;Thorsdottir and others 2004) and being given as treatment for preterm birth (Sattar and others 1998;Smuts and others 2003). others (2007, 2008) also reported that both excess and deficient amounts of dietary ω-3 fatty acids during pregnancy and lactation can cause postnatal growth retardation as well as sensory and neurological abnormalities in the offspring.…”

Section: Pufas In Human Healthmentioning

confidence: 99%

PUFAs in Fish: Extraction, Fractionation, Importance in Health

Ferdosh¹,

Zaidul²,

Selamat³

et al. 2009

Comp Rev Food Sci Food Safe

141

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“…One possible explanation for this may be that these studies were performed in a population with a high baseline intake of nҀ3 fatty acids (21). In the Japan EPA Lipid Intervention Study (JELIS), most of the population had a baseline intake of fish above the threshold for preventing cardiac death but, still, benefits from EPA supplementation were observed (4).…”

Section: N؊3 Fatty Acids Effects On Cardiovascular Disease and Intakementioning

confidence: 99%

n−3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects

Jung

Torrejón

Tighe

et al. 2008

The American Journal of Clinical Nutrition

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Dietary nҀ3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of nҀ3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of nҀ3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.Am J Clin Nutr 2008;87(suppl):2003S-9S.

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Summary of a workshop on n−3 fatty acids: current status of recommendations and future directions

Cited by 60 publications

References 0 publications

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

PUFAs in Fish: Extraction, Fractionation, Importance in Health

n−3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects

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