Sunlight‐driven antibacterial activity of a novel zinc oxide quantum dot and its optimization using Box–Behnken design—A medicament for communicable disease protective wearables

Flora, R. Mary Nancy; Sivashanmugam, P.; Kowsalya, P.; Chamundeeswari, M.

doi:10.1002/bab.2345

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…Nano- and microscale ZnO-based antibacterial agents represent viable and attractive candidates for novel applications. These include multifunctional dressings [ 37 ], nanostructured scaffolds [ 38 ], photocatalytic wearables [ 39 ], and more [ 40 ]. As such, insights into the fundamental interactions at the interface of the crystalline surface and bacteria cell wall as well as the solid–liquid interface between the free surface and the local bacterial environment are necessary to improve both the control and design of potential antibacterial agents.…”

Section: Discussionmentioning

confidence: 99%

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

et al. 2023

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Nano- and microscale zinc oxide (ZnO) exhibits significant potential as a novel antibacterial agent in biomedical applications. However, the uncertainty regarding the underlying mechanisms of the observed antimicrobial action inhibits the realization of this potential. Particularly, the nature of interactions at the free crystalline surface and the influence of the local bacterial environment remains unclear. In this investigation, we utilize ZnO particles synthesized via tunable hydrothermal growth method as a platform to elucidate the effects of interactions with phosphate-rich environments and differentiate them from those with bacteria. This is achieved using the time- and energy-dependent surface photovoltage (SPV) to monitor modifications of the surface electronic structure and surface charge dynamics of the ZnO particles due to these interactions. It is found that there exists a dramatic change in the SPV transients after exposure to phosphate-rich environments. It also presents differences in the sub-bandgap surface electronic structure after these exposures. It can be suggested that these phenomena are a consequence of phosphate adsorption at surface traps corresponding to zinc deficiency defects. This effect is shown to be suppressed in the presence of Staphylococcus aureus bacteria. Our results support the previously proposed model of the competitive nature of interactions between S. aureus and aqueous phosphates with the free surface of ZnO and bring greater clarity to the effects of phosphate-rich environments on bacterial growth inhibition of ZnO.

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Section: Discussionmentioning

confidence: 99%

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

et al. 2023

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“…The Design Expert-13 software was utilized to analyze the response surfaces within the experimental domain. 30 To ensure the reliability of the experimental results, three additional confirmation experiments were carried out. Subsequently, under the optimized conditions determined through the Box-Behnken design, vibrating sample magnetometry examinations were conducted after synthesizing H-NPs to validate the effectiveness of the experimental approach.…”

Section: Data Analysis Of Box-behnken Design For H-npsmentioning

confidence: 99%

Optimization of hematite nanoparticles from natural ore as novel imaging agents: A Green Chemistry approach

Asha,

Chamundeeswari,

Flora

et al. 2024

Biotech and App Biochem

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In this research, we propose an environmentally friendly method for producing hematite nanoparticles (H‐NPs) from natural hematite ore, focusing on their application as efficient contrast agents in x‐ray and computed tomography (CT) imaging for medical purposes. The process involves the reduction of iron oxide within the ore to attain the desired hematite phase, crucial for synthesizing H‐NPs. To ensure sustainability, we adopted a Green Chemistry approach, utilizing a combination of carbon soot and limestone for the purification process, thereby achieving eco‐conscious production. The produced H‐NPs were thoroughly characterized using various analytical techniques, such as x‐ray fluorescence (XRF), x‐ray diffraction (XRD), Fourier transmission infrared spectroscopy (FT‐IR), and FESEM‐EDX (field emission scanning electron microscopy‐energy‐dispersive x‐ray spectroscopy). XRD analysis confirmed the crystalline rhombohedral hexagonal lattice structure, while FT‐IR spectra indicated the presence of characteristic Fe–O stretching modes in line with the expected molecular composition. FESEM‐EDX imaging unveiled agglomerated particles, ranging in size from 54.6 to 149.9 nm for iron ore and 22 nm for H‐NPs. These particles were primarily composed of iron (Fe) and oxygen (O). The magnetic properties of the H‐NPs were investigated through vibrating sample magnetometer (VSM) studies, highlighting their distinct ferromagnetic behavior. Of particular significance, the H‐NPs demonstrated exceptional performance as contrast agents in both x‐ray and CT imaging. Even at minimal concentrations, they exhibited remarkable x‐ray absorption capabilities. CT scans further validated their exceptional absorptive capacity. These findings emphasize the potential of H‐NPs as valuable assets in medical imaging, serving as sustainable tools for enhanced diagnostic applications. The study showcases an eco‐conscious approach to harnessing natural resources, paving the way for a greener and more effective utilization of H‐NPs in the medical imaging landscape.

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“… 5 ZnO QDs with sunlight-driven antibacterial activity can be used for communicable disease protective wearables. 6 Sarkar et al reported that luminescent defect-engineered ZnO QDs have potential as a new, safe, and economical multifunctional active ingredient for skin UV protection. 7 ZnO QDs was also used to fabricated gas sensor for NO 2 and methanol detection.…”

Section: Introductionmentioning

confidence: 99%

Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells

Yang¹,

Wang²,

Song³

et al. 2023

IJN

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Purpose ZnO quantum dots (QDs) are composed of less toxic metals than other QDs but have the same interesting photochemical properties. Thus, they have received considerable attention recently. Nevertheless, their toxicity cannot be ignored. Methods In this study, we incubated ZnO QDs with human SMMC-7721 cells for 24 h to assess their nanotoxicity through proteomics (Fold change >1.5 and p -value <0.05) and metabolomics (Fold change ≥ 1.5; VIP ≥ 1; p -value < 0.05) analyses. Results Both of 174 and 219 significantly changed metabolites were identified in human SMMC-7721 cells treated with 20 and 50 µg/mL ZnO QDs, respectively. ZnO QDs significantly modified metabolic pathways, including purine metabolism, ferroptosis, morphine addiction, alcoholism, cGMP-PKG signaling, and Cushing syndrome. Moreover, we identified 105 and 8 differentially expressed proteins in cells treated with 20 and 50 µg/mL ZnO QDs, and the pathways of alcoholism and Cushing syndrome were enriched. Conclusion ZnO QDs did not affect cell viability in a CCK8 assay, but disturbed the level of intracellular metabolites and proteins at 20 µg/mL. The KEGG analyses of the metabolomics and proteomics data both enriched the alcoholism and Cushing syndrome pathways. These results provide an experimental basis for future research on the safe use of nanomaterials.

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Sunlight‐driven antibacterial activity of a novel zinc oxide quantum dot and its optimization using Box–Behnken design—A medicament for communicable disease protective wearables

Cited by 4 publications

References 57 publications

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

Optimization of hematite nanoparticles from natural ore as novel imaging agents: A Green Chemistry approach

Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells

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