<sup>1</sup>H-MR Spectroscopy in the Human Spinal Cord

Höck, A.; Henning, A; Boesiger, Peter; Kollias, Spyros

doi:10.3174/ajnr.a3342

Cited by 39 publications

(69 citation statements)

References 35 publications

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“…Subject motion is a major challenge for MRS since it often leads to increased linewidth, frequency shifts, reduced peak areas and insufficient water suppression and most importantly to a displacement of the acquisition voxel. In particular, if the region of interest is small and inhomogeneous, even small movements will shift the measurement voxel out of the region of interest, resulting in inaccurate quantification results.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, for spinal cord 1 H‐MRS, subject movement is critical, since even a small movement (>1 mm) can already lead to a voxel shift from the cord to the cerebro‐spinal fluid (CSF), intervertebral disk or vertebral body, which significantly changes the measured spectra (e.g. additional lipid peaks ). This may lead to wrong conclusions and incorrect diagnoses .…”

Section: Introductionmentioning

confidence: 99%

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Motion correction and frequency stabilization for MRS of the human spinal cord

Höck

Henning

2016

NMR in Biomedicine

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Subject motion is challenging for MRS, because it can falsify results. For spinal cord MRS in particular, subject movement is critical, since even a small movement > 1 mm) can lead to a voxel shift out of the desired measurement region. Therefore, the identification of motion corrupted MRS scans is essential. In this investigation, MR navigators acquired simultaneously with the MRS data are used to identify a displacement of the spinal cord due to subject motion. It is shown that navigators are able to recognize substantial subject motion (>1 mm) without impairing the MRS measurement. In addition, navigators are easy to apply to the measurement, because no additional hardware and just a minor additional user effort are needed. Moreover, no additional scan time is required, because navigators can be applied in the deadtime of the MRS sequence. Furthermore, in this work, retrospective motion correction combined with frequency stabilization is presented by combining navigators with non-water-suppressed (1)H-MRS, resulting in an improved spectral quality of the spinal cord measurements.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Motion correction and frequency stabilization for MRS of the human spinal cord

Höck

Henning

2016

NMR in Biomedicine

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“…MR spectroscopy may be used to determine prognosis and to guide treatment planning in oncology patients when surgery is not indicated, such as in diffuse brainstem gliomas and intramedullary tumors in the spinal cord (60). A tCho/tNAA peak amplitude ratio of at least 2.1 (either at single-voxel spectroscopy with a TE of 144 or 270 msec or at MR spectroscopic imaging with a TE of 280 msec) was found prognostic of unfavorable outcome in pediatric diffuse pontine gliomas (61).…”

Section: Special Reviewmentioning

confidence: 99%

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Öz¹,

Alger²,

Barker³

et al. 2014

Radiology

559

356

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A large body of published work shows that proton (hydrogen 1 [ 1 H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1 H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1 H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1 H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.q RSNA, 2014 Online supplemental material is available for this article. G.O. (e-mail: gulin@cmrr.umn.edu). 2 The complete list of authors and affiliations is at the end of this article.q RSNA, 2014 Note: This copy is for your personal non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact us at www.rsna.org/rsnarights. Radiology H MR Spectrum of the Brain: Metabolites and Their Biomarker PotentialMR spectroscopy provides a very different basic "readout" than MR imaging, namely a spectrum rather than an techniques were developed. These early localization techniques included pointresolved spectroscopy (PRESS) (1,2) and stimulated echo acquisition mode (STEAM) (3), methods that are now widely used in clinical MR spectroscopy applications.Preliminary studies revealed large differences in metabolite levels in acute stroke (4), chronic multiple sclerosis (5), and brain tumors compared with healthy brain (6). Although this work stimulated a surge of interest in 1 H MR spectroscopy for diagnosing and assessing CNS disorders during the early days of the "Decade of the Brain" (1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999), many suboptimal patient studies (7) and the lack of consistent guidelines have led to a situation where, 20 years later, MR spectroscopy is still considered an "investigational technique" by some medical professionals and health care organizations. However, the ability to make an early, noninvasive diagnosis or to increase confidence in a suspected diagnosis is highly valued by patients and clinicians alike. As a result, an increasing number of imaging centers are incorporating MR spectroscopy into their clinical protocols for brain...

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“…Pharmacokinetic modeling by using Tofts and Tofts extended models was also performed to derive maps of volume transfer constant (K trans ) and extravascular extracellular volume fraction (v e ); for the Tofts extended model, maps of blood plasma fraction (v p ) were also obtained. Maps of 2 (expressing the goodness of fit) were obtained for both models.…”

Section: Image Reconstructionmentioning

confidence: 99%

“…2 In humans, MR perfusion studies of spinal cord lesions are limited to very few related articles 3,4 using DSC MR perfusion in the cervical region.…”

mentioning

confidence: 99%

Dynamic Contrast-Enhanced MR Perfusion of Intradural Spinal Lesions

Cuvinciuc¹,

Viallon

Barnaure³

et al. 2016

AJNR Am J Neuroradiol

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SUMMARY:Fifteen patients with intradural spinal lesions were examined with an optimized dynamic contrast-enhanced MR perfusion sequence at 1.5T and 3T. SNR and mean contrast-to-noise ratio were better on 3T compared with 1.5T (P Յ .05). The goodness of fit of the Tofts and Tofts extended pharmacokinetic models was similar between 1.5T and 3T. Thus, dynamic contrast-enhanced MR perfusion of intradural spinal canal lesions is technically feasible at 1.5T and 3T, with better image quality at 3T.

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¹H-MR Spectroscopy in the Human Spinal Cord

Cited by 39 publications

References 35 publications

Motion correction and frequency stabilization for MRS of the human spinal cord

Motion correction and frequency stabilization for MRS of the human spinal cord

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Dynamic Contrast-Enhanced MR Perfusion of Intradural Spinal Lesions

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1H-MR Spectroscopy in the Human Spinal Cord

Cited by 39 publications

References 35 publications

Motion correction and frequency stabilization for MRS of the human spinal cord

Motion correction and frequency stabilization for MRS of the human spinal cord

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Dynamic Contrast-Enhanced MR Perfusion of Intradural Spinal Lesions

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¹H-MR Spectroscopy in the Human Spinal Cord