Super-tough double-network hydrogels reinforced by covalently compositing with silica-nanoparticles

Wang, Qiang; Hou, Ruixia; Cheng, Ya‐Jun; Fu, Jun

doi:10.1039/c2sm07233e

Cited by 208 publications

(181 citation statements)

References 38 publications

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“…Previous reports with silica-based nanoparticles embedded hydrogel matrices suggested a potential decrease in porosity with an increasing concentration of silicates. 29 We also noticed a similar trend in the group with the highest concentration of nSi (Fig. 1C).…”

Section: Resultssupporting

confidence: 75%

Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments

et al. 2016

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The ability to modulate stem cell differentiation in a three dimensional (3D) microenvironment for bone tissue engineering in absence of exogenous pharmaceutical agents such as bone morphogenic protein (BMP-2) remains a challenge. In this study, we introduce extracellular matrix (ECM)-mimicking nanocomposite hydrogels to induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) for bone regeneration in absence of any osteoinducting factors. In particular, we have reinforced photocrosslinkable collagen-based matrix (gelatin methacryloyl, GelMA) used disk-shaped nanosilicates (nSi), a new class of two-dimensional (2D) nanomaterials. We show that nanoengineered hydrogels supported migration and proliferation of encapsulated hMSCs, with no signs of cell apoptosis or inflammatory cytokine responses. The addition of nSi significantly enhances osteogenic differentiation of encapsulated hMSCs as evident by the increase in alkaline phosphates (ALP) activity and deposition of biomineralized matrix compared to GelMA without nSi. We also show that microfabricated nanoengineered microgels can be used to pattern and control cellular behaviour. Furthermore, we also show that nanoengineered hydrogel have high biocompatibility as determined by in vivo experiments using immunocompetent rat model. Specifically, the hydrogels showed minimum localized immune responses, indicating it ability for tissue engineering applications. Overall, we showed the ability of nanoengineered hydrogels loaded with 2D nanosilicates for osteogenic differentiation of stem cells in vitro, in absence of any growth factors such as BMP-2. Our in vivo studies show high biocompatibility of nanocomposites and show the potential for growth factor free bone regeneration.

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Section: Resultssupporting

confidence: 75%

Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments

et al. 2016

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“…Typically, the swelling ratios of the hydrogels in water increase with time until reaching the equilibrium at about 350 h. The ESR of the composite hydrogels decreases with the increase of nHAp content. The lower ESR values indicate that the composite hydrogels have higher degree of crosslinking than the PAAm hydrogel [26], in consistent with the results of mechanical tests and FT-IR characterizations. Photographs of the hydrogels before and after equilibrium swelling are shown in Fig.…”

Section: Swelling Kineticssupporting

confidence: 88%

Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties

Wang

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Thus, the amount of micro-network structures CNTs-4 became less. As reported previously, the formation of embedded micro-network structures led to increase in the compressive strength and toughness [26,34–36]. However, the compressive strength of CNTs-4 was higher than that of CNTs-1, which was attributed to the stronger reinforced effect of CNTs at higher concentration.…”

Section: Resultsmentioning

confidence: 60%

Superior Mechanical Properties of Double-Network Hydrogels Reinforced by Carbon Nanotubes without Organic Modification

Dong

Huang

Wang

et al. 2013

IJMS

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A facile method is developed to fabricate nanocomposite double-network (DN) gels with excellent mechanical properties, which do not fracture upon loading up to 78 MPa and a strain above 0.98, by compositing of carbon nanotubes (CNTs) without organic modification. Investigations of swelling behaviors, and compressive and tensile properties indicate that equilibrium swelling ratio, compressive modulus and stress, fracture stress, Young’s modulus, and yield stress are significantly improved in the presence of CNTs. Scanning electron microscopy (SEM) reveals that the pore size of nanocomposite DN gels is decreased and some embedded micro-network structures are observed on the fracture surface in comparison to DN gels without CNTs, which leads to the enhancement of mechanical properties. The compressive loading-unloading behaviors show that the area of hysteresis loop, dissipated energy, for the first compressive cycle, increases with addition of CNTs, which is much higher than that for the successive cycles. Furthermore, the energy dissipation mechanism, similar to the Mullins effect observed in filled rubbers, is demonstrated for better understanding the nanocomposite DN polymer gels with CNTs.

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Super-tough double-network hydrogels reinforced by covalently compositing with silica-nanoparticles

Cited by 208 publications

References 38 publications

Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments

Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments

Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties

Superior Mechanical Properties of Double-Network Hydrogels Reinforced by Carbon Nanotubes without Organic Modification

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