Superior renoprotective effects of the combination of breviscapine with enalapril and its mechanism in diabetic rats

Protective Effects of Scutellarin on Type II Diabetes Mellitus-Induced Testicular Damages Related to Reactive Oxygen Species/Bcl-2/Bax and Reactive Oxygen Species/Microcirculation/Staving Pathway in Diabetic Rat

“…It is also being used in the treatment of cerebral ischemia and infantile acute viral myocarditis [ 44 , 45 ]. SCU exhibits antioxidant property which has been studied for its protective effects on neuro [ 46 ], blood circulation [ 47 ], and nephropathy [ 18 ]. SCU has been reported to be effective in dilating blood vessels, increasing blood flow rate, improving microcirculation and hemodynamics, decreasing blood viscosity, and preventing platelet conglomeration [ 47 , 48 ].…”

“…SCU has been reported to be effective in dilating blood vessels, increasing blood flow rate, improving microcirculation and hemodynamics, decreasing blood viscosity, and preventing platelet conglomeration [ 47 , 48 ]. Due to its antioxidant property and its ability to improve microcirculation, SCU has been studied for prevention and treatment of diabetic complications, such as diabetes associated cardiovascular disease [ 19 ], diabetic nephropathy [ 18 ], and diabetic retinopathy [ 49 ]. However, whether SCU can prevent and treat diabetes associated productive disorder is elusive.…”

“…SCU Scheme 1 possesses antioxidant property and has been proved to improve microcirculation [ 17 ]. Preclinical data showed that SCU can ameliorate diabetic nephropathy through reducing ROS generation [ 18 ] and reduce cardiomyocyte apoptosis by upgrading the expression of proapoptotic genes in Bcl-2 family [ 19 ]. Acute and toxicological study showed that LD 50 value of SCU could not be measured, and its maximum tolerance was 10 g/kg.…”

Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta‐Analysis

“…In addition, the therapeutic mechanisms for these effects have been partly revealed through experimental studies. For example, several pairwise meta-analyses have shown the beneficial effects of DZH (Breviscapus) as an antiproteinuria, in improving albumin Evidence-Based Complementary and Alternative Medicine Evidence-Based Complementary and Alternative Medicine level, and in lowering cholesterol and triglyceride for hypertension-induced renal injury and diabetic nephropathy; the mechanism may be correlated with synergetic suppression of increased oxidative stress [25][26][27]. Recent studies have suggested that DH can effectively decrease urine protein excretion by multiple pathways, as well as confer lipid-lowering effects [28][29][30].…”

Effect of breviscapine injection on clinical parameters in diabetic nephropathy: A meta-analysis of randomized controlled trials

“…The abnormal metabolism of glucose or free fatty acids via mitochondria pathways, and the activation of nicotinamide adenine dinucleotide phosphate oxidases via PKC have been recognized as contributors towards the production of oxidants (55). Breviscapine possesses a variety of pharmacological functions other than hemodynamic effects, and can serve as an anti-oxidative stress agent and inhibitor of PKC (56,57). In addition, Zhao et al (58) and Wagener et al (59) observed in diabetic rat models that breviscapine can inhibit podocyte apoptosis by modulating the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-Associated X Protein genes.…”