Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Rizvi, Imran; Zaman, Shamsuz; Zaidi, Noorin; Ashraf, Syed Mohammad Kamil; Kumar, Arun; Gupta, Ankush; Ahmad, Mehtab

doi:10.1136/bcr.01.2012.5487

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…Unexpected sudden deaths may also be encountered. Therefore, in less than 1% of the children with cancer, VCSS signs, such as dyspnea, coughing stridor, dysphagia, jugular venous distention, edema, cyanosis, and the need for intensive care, particularly more in young children, may arise [1,2,4]. In our patients the superficial veins' becoming prominent, swelling in the face due to the impairment of venous return were the most frequently encountered signs.…”

Section: Discussionmentioning

confidence: 55%

“…may also ariset from intrinsic causes associated with the treatment of congenital cardiac defects or with thrombosis developing in connection with the central venous catheters. Vena cava superior syndrome gives rise to complications that cause morbidity and mortality to increase morbidity and mortality [2,3]. Although there are many unanswered questions about VCSS in the pediatric age group, the number of studies on its clinical findings is quite low.…”

mentioning

confidence: 99%

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Vena Cava Superior Syndrome in Children With Mediastinal Tumors: Single Center Experience

Özcan

Ünal

Karakükçü

et al. 2019

North Clin Istanbul

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V ena cava superior syndrome (VCSS) is a clinical picture emerging with the impairment of blood flow and venous return to the heart as a result of the obstruction of superior vena cava. Depending on the acutely developing obstruction of blood flow, respi-ratory distress and neurologic symptoms arise [1]. VCSS was first described by William Hunter in 1757 in a patient with syphilitic aorta aneurism. Vena cava syndrome in children develops as a result of external pressure depending on the oncologic problems. VCSS ABSTRACT OBJECTIVE: Vena cava superior syndrome comprises various symptoms of compression of vena cava superior. The results of increased venous pressure in the upper body may cause edema of the head and neck associated with cyanosis, plethora and distended subcutaneous vessels. Vena cava superior syndrome is rare in childhood. Therefore, we planned this retrospective study.

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Section: Discussionmentioning

confidence: 55%

mentioning

confidence: 99%

Vena Cava Superior Syndrome in Children With Mediastinal Tumors: Single Center Experience

Özcan

Ünal

Karakükçü

et al. 2019

North Clin Istanbul

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“…In a study by Ingram et al [ 11 ], 31% of 333 pediatric patients with HL presented with a mediastinal mass, but the prevalence of SVC syndrome was as low as 2%. In the literature on adults, HL-associated SVC syndrome is rare, with only 24 cases reported, including 20 cases of HL that initially presented as SVC syndrome and 4 cases in which SVC syndrome developed under the influence of therapy [ 12 – 29 ] ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Hodgkin Lymphoma-Associated Superior Vena Cava Syndrome: A Case Report and Review of the Literature

Amr

Kalla

2021

Am J Case Rep

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Patient: Male, 53-year-old Final Diagnosis: Hodgkin lymphoma • superior vena cava syndrome Symptoms: Dry cough • dyspnea • facial edema • fatigue Medication: — Clinical Procedure: — Specialty: Hematology • Oncology Objective: Rare co-existance of disease or pathology Background: Hodgkin lymphoma (HL) is a relatively rare etiology of superior vena cava (SVC) syndrome, with only 24 cases reported in the literature. The characteristics, management, and prognosis of HL-associated SVC syndrome remain unclear. This case report describes nodular sclerosis classical HL and the associated clinical manifestations presenting as SVC syndrome in a middle-aged patient, and it summarizes the characteristics of HL-associated SVC syndrome. Case Report: In this case report, we present a 53-year-old Hispanic man with progressively worsening dyspnea, dry cough, facial and neck edema, and dysphagia. SVC syndrome was diagnosed, and pathology revealed nodular sclerosis classical HL. The patient was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. SVC syndrome improved, and repeated imaging showed that the lymphoma had decreased in size and had become metabolically inactive. Conclusions: We reviewed the characteristics, management, and prognosis of HL-associated SVC syndrome, which may indicate more advanced and recurrent progression in patients with HL. This possibility suggests that physicians should provide urgent diagnosis and closer follow-up, and more aggressive therapies may be needed because of the high risk of recurrence. Therapy may induce late-onset SVC syndrome in patients with HL.

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“…Lung cancer accounts for 85% of all cases of SVCS with malignant etiology. [ 20 ] Other causes of SVCS include aortic aneurysm, thyromegaly, fibrosing mediastinitis from prior irradiation, or histoplasmosis and thrombosis due to central venous access. [ 20 ] In the superior vena cava (SVC) obstruction, CT study typically shows a lack of opacification of the SVC, an intraluminal filling defect or severe narrowing of the SVC, and visualization of collateral vessels [ Figure 8 ].…”

Section: Mediastinummentioning

confidence: 99%

“…[ 20 ] Other causes of SVCS include aortic aneurysm, thyromegaly, fibrosing mediastinitis from prior irradiation, or histoplasmosis and thrombosis due to central venous access. [ 20 ] In the superior vena cava (SVC) obstruction, CT study typically shows a lack of opacification of the SVC, an intraluminal filling defect or severe narrowing of the SVC, and visualization of collateral vessels [ Figure 8 ]. [ 21 ] In general, network of smaller venous plexuses connecting the venous drainage of upper extremities is not opacified on contrast CT.…”

Section: Mediastinummentioning

confidence: 99%

Disease- and treatment-related complication on F-18-Fluorodeoxyglucose positron emission tomography/computed tomography in oncology practice: A pictorial review

et al. 2017

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F-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is routinely performed in oncology patients for various indications including staging, restaging, recurrence detection, and treatment response evaluation. Many disease- and treatment-related complications can be incidentally detected on PET/CT, which may be due to the complication of radiotherapy, chemotherapy, intervention, or primary tumor itself. Some of these complications could be life threatening and need urgent intervention. Therefore, these incidental findings should be recognized on PET/CT and immediately informed to the treating physicians if required urgent intervention.

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Superior vena cava syndrome caused by Hodgkin's lymphoma in an adolescent girl

Cited by 5 publications

References 16 publications

Vena Cava Superior Syndrome in Children With Mediastinal Tumors: Single Center Experience

Vena Cava Superior Syndrome in Children With Mediastinal Tumors: Single Center Experience

Hodgkin Lymphoma-Associated Superior Vena Cava Syndrome: A Case Report and Review of the Literature

Disease- and treatment-related complication on F-18-Fluorodeoxyglucose positron emission tomography/computed tomography in oncology practice: A pictorial review

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