Superoxide Dismutase and Cancer Therapy

Teoh-Fitzgerald, Melissa; Domann, Frederick E.

doi:10.1007/978-1-61779-397-4_4

Cited by 3 publications

(4 citation statements)

References 138 publications

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“…) : Effect of H 2 O 2 and tomato extract on liver enzymes and albumin & This result in agreement with the some studies where reported depletion of GSH activity as a result of increase of oxidative stress(34,35,36). many authors reported that if the amount of ROS above the scavenging capacities of antioxidant enzymes lead to irreversible damage of cell(37). In the present study exposure of animals to the 0.75% H 2 O 2 in drinking water, caused significant decreased activity of antioxidant enzymes such catalase and superoxide dismutase , these enzymes work together, catalase hydrolyzed H 2 O 2 that formed via superoxide anion dismutation by activity of SOD (37).…”

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confidence: 48%

Study the Antioxidant Effect of Tomato Extract in Oxidative Stressed Rats.

Humaish¹

2016

Bas.J.Vet.Res.

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Tomato, is today the most popular garden vegetable in worldwide, because of its high consumption. Tomato contain a variety of phytochemical , such as lycopene , flavonoids, glycosides and other chemical constituents that have been beneficial protective effect. The present study carried out to evaluate the effect of two different doses (2 mg/kg BWand 4 mg/kg BW) of tomato extract against hydrogen peroxide-induced oxidative stress in albino rats. Thirty two adult male albino rats randomly divided into four equal groups were used in this study, the results revealed that administration of 0.75% H 2 O 2 in drinking water (groupI) produced significant decline of antioxidant enzymes (superoxide dismutase (SOD) , glutathione (GSH), catalase (CAT)) and serum albumin concentration , with significant elevation of lipid peroxidation rate by estimation of malondialdehyde (MDA) and peroxynitrite radical (ONOO). Also, H 2 O 2 caused significant increase in serum concentration of alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), and bilirubin. On the other hand the animals treated with H 2 O 2 plus 4 mg/kg BW of tomato extract (groupIII) showed significant increase of SOD, GSH, CATand albumin with significant reduction of MDA ,ONOO, ALT, AST, ALP, and bilirubin comparing with control group. Depending on the above oxidant and antioxidant markers, it seems that 4 mg/kg BW. of tomato extract exert beneficial action protect against H 2 O 2 induced oxidative stress in rats.

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supporting

confidence: 48%

Study the Antioxidant Effect of Tomato Extract in Oxidative Stressed Rats.

Humaish¹

2016

Bas.J.Vet.Res.

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“…Depending on the intensity and duration of the stress as well as susceptibility of exposed living organisms, both induction and inhibition of antioxidant enzymes are observed. It has been revealed that if the amount of ROS reaches the threshold level which overwhelms the antioxidant capacities, irreversible damage will occur [ 45 ]. Similar to the results from our previous studies [ 22 – 24 ], activities of antioxidant enzymes were markedly inhibited in the liver of NDEA-treated animals.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the treatment with tomato paste caused a recovery of the decreased activity of antioxidant enzymes. Superoxide dismutase (SOD) is the primary superoxide scavenger and has become an important potential chemopreventive modality in view of the link between ROS and carcinogenesis [ 45 ]. In the present study, only the higher dose of tomato paste caused an increase in SOD activity in NDEA-treated rats.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats

et al. 2014

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Lycopene is a carotenoid pigment produced by vegetables and fruits, with tomatoes and their processed products being the most abundant sources. A high number of conjugated dienes make lycopene a powerful radical scavenger. Its antioxidant properties are considered to be primarily involved in many beneficial health effects. The present study was designed to assess the protective effect of lycopene-enriched tomato paste against N-nitrosodiethylamine (NDEA)-induced oxidative stress in rats. Forty-eight male Wistar rats were divided randomly into six groups. Four groups were treated with tomato paste, per os, for 28 days in doses which were equivalent to 0.5 (groups II and V) and 2.5 mg/kg b.w./day of lycopene (groups III and VI). Rats from groups IV–VI were given intraperitoneally a single dose of NDEA, 150 mg/kg b.w. Group I (control) was given distilled water. Pretreatment with tomato paste protected the antioxidant enzymes: superoxide dismutase, catalase and glutathione reductase. Their activity was recovered by 32–97 %, as compared to NDEA-treated rats. Microsomal lipid peroxidation in the liver was decreased in rats pretreated with a lower dose of tomato paste by 28 %, as compared to animals given NDEA alone. Pretreatment with tomato paste caused a decrease in plasma concentration of protein carbonyls, even below the control level, in rats given NDEA. Moreover, a 10 % reduction of DNA damage in leucocytes caused by NDEA was observed. The tomato paste tested was able to suppress NDEA-induced oxidative stress in rats.

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Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

Han,

Santos

2024

Advanced Materials

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Proteins have emerged as promising therapeutics in oncology due to their great specificity. Many treatment strategies are developed based on protein biologics, such as immunotherapy, starvation therapy, and pro‐apoptosis therapy, while some protein biologics have entered the clinics. However, clinical translation is severely impeded by instability, short circulation time, poor transmembrane transportation, and immunogenicity. Micro‐ and nano‐particles‐based drug delivery platforms are designed to solve those problems and enhance protein therapeutic efficacy. This review first summarizes the different types of therapeutic proteins in clinical and research stages, highlighting their administration limitations. Next, various types of micro‐ and nano‐particles are described to demonstrate how they can overcome those limitations. The potential of micro‐ and nano‐particles are then explored to enhance the therapeutic efficacy of proteins by combinational therapies. Finally, the challenges and future directions of protein biologics carriers are discussed for optimized protein delivery.

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Superoxide Dismutase and Cancer Therapy

Cited by 3 publications

References 138 publications

Study the Antioxidant Effect of Tomato Extract in Oxidative Stressed Rats.

Study the Antioxidant Effect of Tomato Extract in Oxidative Stressed Rats.

Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats

Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

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