Superparamagnetic iron oxide based nanoprobes for imaging and theranostics

Lam, Tina Poy Wing; Pouliot, Philippe; Avti, Pramod K.; Lesage, Frédéric; Kakkar, Ashok

doi:10.1016/j.cis.2013.06.007

Cited by 98 publications

(54 citation statements)

References 240 publications

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“…In fact, the relevance of magnetic nanoparticles in biomedicine, e.g., in hyperthermia [434,435], drug delivery [436,437], biosensors [438,439], protein and cell manipulation (e.g., magnetic separation) [440,441], or magnetic resonance imaging (MRI) [442,443], among others, has already been widely demonstrated. In fact, the unique properties of nanoparticles make them excellent platforms to combine both therapeutic and diagnostic capabilities in a single entity, i.e., theranostics [444]. Similarly, magnetic nanoparticles are good building blocks for multifunctional core/shell nanoparticles for biomedical use, i.e., combining the magnetism (e.g., for hyperthermia) and another functionality (e.g., for optical imaging or to improve biocompatibility) [29,31].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Applications of exchange coupled bi-magnetic hard/soft and soft/hard magnetic core/shell nanoparticles

et al. 2015

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A B S T R A C TThe applications of exchange coupled bi-magnetic hard/soft and soft/hard ferromagnetic core/shell nanoparticles are reviewed. After a brief description of the main synthesis approaches and the core/shell structural-morphological characterization, the basic static and dynamic magnetic properties are presented. Five different types of prospective applications, based on diverse patents and research articles, are described: permanent magnets, recording media, microwave absorption, biomedical applications and other applications. Both the advantages of the core/shell morphology and some of the remaining challenges are discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Applications of exchange coupled bi-magnetic hard/soft and soft/hard magnetic core/shell nanoparticles

et al. 2015

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“…34 Since these two iron oxides exhibit superparamagnetic behavior, the loss of their net magnetization in the absence of an external magnetic field limits their tendency for self-aggregation, and this helps to obtain a good biological response. 10 Unfortunately, the ubiquitous Van der Waals forces induce natural aggregation of the particles, and to circumvent this problem, a large portfolio of chemical approaches exists that stabilize the particles. These approaches include the modification of the surface of the particles with diverse materials.…”

Section: T 2 Contrast Agentsmentioning

confidence: 99%

“…16 Another difference with T 1 contrast agents is that under high magnetic fields, R 2 , the relaxation rate, tends asymptotically to a positive constant. 10 Iron oxide nanoparticles have been used as T 2 contrast agents for more than 25 years. These iron oxides can be ferromagnetic or superparamagnetic, depending on the size of the core of the nanoparticle.…”

Section: T 2 Contrast Agentsmentioning

confidence: 99%

“…MRI relies on large magnetic fields and radio frequencies (RFs), and makes use of the relaxation times of protons in mobile molecules such as water, lipids, and proteins that are present in organs at different concentrations, to produce high-resolution soft tissue anatomical images with good endogenous contrast. 10 In the following sections, we review many of the most innovative approaches that have been adopted in the recent history of MRI contrast agents based on nanoparticles; mainly on superparamagnetic iron oxide nanoparticles. In this mini-review, we also include polynuclear or particulate contrast agents that are the result of progression from previous ionic agents.…”

Section: Introductionmentioning

confidence: 99%

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Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

282

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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“…Several sorts of magnetic nanoparticles have been widely investigated for biomedical applications, among which iron oxide-based magnetic nanoparticles are very promising candidates due to their unique features like biocompatibility, large surface area and superparamagnetic behavior that make them an ideal tool for cell separation, magnetic resonance imaging (MRI) [11][12], cancer treatment by hyperthermia [13][14][15] drug delivery systems (DDS) [16,17]. In all these applications it is necessary to maintain the nanostructure of the individual particles in order to preserve the superparamagnetic behavior.…”

Section: Introductionmentioning

confidence: 99%

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

Torres-Cadenas¹,

Bravo-Patino²,

Zárate‐Medina³

et al. 2017

Epitoanyag - JSBCM

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recent years a surge has been seen in magnetic nanoparticles applications in several areas, particularly in biomedical field. the promising features of the iron oxide based magnetic nanoparticles make them an ideal tool for mri contrast agents, hyperthermia, and as drug delivery systems (DDs). the present paper describes the design and synthesis of Bao·6Fe 2 o 3 nanostructured meso-macroporous spherical aggregates by sol-gel method via spray drying technique. the obtained spherical aggregates have micrometric size, which let them to be carried by the bloodstream to a specific site where the drug is going to be release. the obtained hierarchical porous structure combined with the interconnected mesoporosity allow the body fluids to be transport through the aggregates; and the macroporosity allows the load of large molecules, like peptides. Furthermore, the structural and morphological characterization of the obtained Bao·6Fe 2 o 3 aggregates were carried out using X-ray diffraction and field emission scanning electron microscopy. keywords: nest-like morphology, hierarchical porous structure, drug delivery, barium hexaferrite.

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Superparamagnetic iron oxide based nanoprobes for imaging and theranostics

Cited by 98 publications

References 240 publications

Applications of exchange coupled bi-magnetic hard/soft and soft/hard magnetic core/shell nanoparticles

Applications of exchange coupled bi-magnetic hard/soft and soft/hard magnetic core/shell nanoparticles

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

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