Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

Klein, Susan Blakeley; Sommer, Anja; Distel, Luitpold; Neuhuber, Winfried; Kryschi, Carola

doi:10.1016/j.bbrc.2012.07.108

Cited by 146 publications

(113 citation statements)

References 21 publications

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“…After the incorporation of the nanoparticles, a higher concentration of reactive oxygen species (ROS) was found in the cells, improving the response to irradiation [64] .…”

Section: Radiotherapymentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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Abstract:Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of " theranostics " . The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

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“…After the incorporation of the nanoparticles, a higher concentration of reactive oxygen species (ROS) was found in the cells, improving the response to irradiation [64] .…”

Section: Radiotherapymentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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show abstract

“…High-Z elements with larger X-ray interaction cross-sections than light elements (for example, H, O, N and C) could increase the energy deposition and radiolytic hydrolysis in the vicinity of the materials. 2 Several high-Z materials, such as germanium nanoparticles (NPs), 13 iron oxide NPs, 14,15 lanthanidebased compounds, 16 iodine, 17 gold-based NPs 18 and nuclear-targeting gadolinium-based NPs, 19 have recently been used as adjuvants to enhance cellular radiosensitivity. However, few are efficient in in vivo cancer radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi 2 Se 3 -CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi 2 Se 3 -CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi 2 Se 3 -CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi 2 Se 3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi 2 Se 3 NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

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“…ROS may be the underlying genotoxicity mechanism for the MNPs, and hence, it has to be balanced according to non-invasive tumor imaging and drug delivery applications [31,32]. It has been widely reported that intracellular ROS production is considerably affected by the size and surface chemistry of MNPs [33,34]. Additional studies that quantify the ROS toxicity caused by MNPs in specific subcellular compartments are still needed.…”

Section: Introductionmentioning

confidence: 99%

Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles

Yang

Cui

et al. 2015

Sci. China Mater.

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Engineered iron oxide magnetic nanoparticles (MNPs) are one of the most promising tools in nanomedicine-based diagnostics and therapy. However, increasing evidence suggests that their specific delivery efficiency and potential long-term cytotoxicity remain a great concern. In this study, using 12 nm γ-Fe2O3 MNPs, we investigated three types of uptake pathways for MNPs into HepG2 cells: (1) a conventional incubation endocytic pathway; (2) MNPs co-administrated with microbubbles under ultrasound exposure; and (3) ultrasound delivery of MNPs covalently coated on the surface of microbubbles. The delivery efficiency and intracellular distribution of MNPs were evaluated, and the cytotoxicity induced by reactive oxygen species (ROS) was studied in detail. The results show that MNPs can be delivered into the lysosomes via classical incubation endocytic internalization; however, microbubbles and ultrasound allow the MNPs to pass through the cell membrane and enter the cytosol via a non-internalizing uptake route much more evenly and efficiently. Further, these different delivery routes result in different ROS levels and antioxidant capacities, as well as intracellular glutathione peroxidase activity for HepG2 cells. Our data indicate that the microbubble-ultrasound treatment method can serve as an efficient cytosolic delivery strategy to minimize long-term cytotoxicity of MNPs.

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Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

Cited by 146 publications

References 21 publications

Magnetic nanoparticles for cancer therapy

Magnetic nanoparticles for cancer therapy

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles

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