Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial

Abstract

To evaluate the effects of supervised exercise training (SET) on cardiometabolic risk, cardiorespiratory fitness and oxidative stress status in 2 diabetes mellitus (T2DM), twenty male subjects with T2DM were randomly assigned to an intervention group, which performed SET in a hospital-based setting, and to a control group. SET consisted of a 12-month supervised aerobic, resistance and flexibility training. A reference group of ten healthy male subjects was also recruited for baseline evaluation only. Participants underwent medical examination, biochemical analyses and cardiopulmonary exercise testing. Oxidative stress markers (1-palmitoyl-2-[5-oxovaleroyl]-sn-glycero-3-phosphorylcholine [POVPC]; 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine [PGPC]) were measured in plasma and in peripheral blood mononuclear cells. All investigations were carried out at baseline and after 12 months. SET yielded a significant modification (p < 0.05) in the following parameters: V'O2max (+14.4%), gas exchange threshold (+23.4%), waist circumference (−1.4%), total cholesterol (−14.6%), LDL cholesterol (−20.2%), fasting insulinemia (−48.5%), HOMA-IR (−52.5%), plasma POVPC (−27.9%) and PGPC (−31.6%). After 12 months, the control group presented a V'O2max and a gas exchange threshold significantly lower than the intervention group. Plasma POVC and PGPC were significantly different from healthy subjects before the intervention, but not after. In conclusion, SET was effective in improving cardiorespiratory fitness, cardiometabolic risk and oxidative stress status in T2DM.

Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways

“…A recent randomized controlled trial on T2DM individuals who were subjected to 12-month of supervised aerobic, resistance and flexibility training demonstrated a reduction in plasma oxidative stress markers, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC) compared to those who received only standard medical care. Exercise also improved low-density lipoprotein (LDL) cholesterol, VO 2max , insulin sensitivity and waist circumference [155]. Concomitantly, T2DM individuals who received 3 months of yoga therapy achieved a 20% reduction in malondialdehyde (MDA), a lipid peroxidation oxidative marker, compared to the non-exercise group.…”

Análisis del entrenamiento resistido en el perfil glicémico: una revisión bibliográfica

“…En el estudio de Hamasaki et al, (2015), utilizando una muestra de pacientes obesos con diabetes tipo 2, los autores detectaron que el ER de baja intensidad con movimiento lento, junto con el EA al 50% de la FC, fue capaz de disminuir la masa corporal (-2.2 kg), la masa grasa corporal (-2.1 kg), y el porcentaje de grasa corporal (-1.1%), mejorando así el porcentaje de lipoproteínas de alta densidad (HDL) (+9.8%) y bajando las lipoproteínas de baja densidad (LDL) (-7.7%) y la hemoglobina glucosilada (HbA1c) (-16%), este último indicador de bienestar de los niveles de glucosa en sangre y en el torrente sanguíneo. En otro estudio, los autores confirmaron que los individuos con diabetes mellitus tipo 2, presentaron una pequeña mejora de la glucemia (-8.5%), HbA1c (-5%), LDL (-20.6%), después de un ER, EA y de flexibilidad (Vinetti et al, 2015).…”

Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions

“…Thus, the potential for skeletal muscle-mediated systemic metabolic effects of exercise is substantial. In fact, a significant mechanism by which exercise training reduces cardiometabolic risk is through increased insulin sensitivity, a concept reinforced by recent data demonstrating that supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes [12]. …”