Cloud computing enables ubiquitous and efficient on-demand access to information, data, and computational resources with the support of modern wired and wireless communication technologies. Cloud computing has been very widely used in education, autonomous vehicles, smart cities/homes, renewable energy, healthcare, engineering, business, and telecommunications, amongst others, with the support of the advances in Artificial Intelligence, Internet of Things (IoT), and Data Science. Such technologies and their applications have made significant impact to the way people live and do business by offering online services and instant communications.Despite of the intensive research effort in the field, some open challenges remain, such as inefficient load balancing and energy management in cloud data centres, high cost to access to the facility, insufficient security and privacy, and low speed big data stream processing. This special issue focuses on recent advances in addressing these challenges and investigating all the aspects of emerging trends, in addition to reporting innovative real-world applications of cloud computing to deliver effective and efficient solutions & Longzhi Yang