Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

Wang, Ning; Tan, Hor‐Yue; Li, Sha; Xu, Yu; Guo, Wei; Feng, Yibin

doi:10.1155/2017/7478523

Cited by 221 publications

(123 citation statements)

References 125 publications

(125 reference statements)

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“…The beneficial role of selenium was obvious in the dietary management of chronic metabolic diseases such a Hyperlipidaemia, Hyperglycemia and Hyperphenylalaninemia [29] .…”

Section: Discussionmentioning

confidence: 99%

Histological and Immunohistochemical Study of Selenium Regenerative Effect on Submandibular and Sublingual Glands of Aging Rats

Elsaied

2019

Egyptian Dental Journal

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Background:The role of Selenium as an antioxidant has become a point of interest for its importance in prevention of cancer and other systemic diseases especially those associated with aging. Objectives:The aim of the present investigation was to investigate the effect of Selenium supplementation on the submandibular and sublingual salivary glands of aging rats through:1-Histological examination. 2-Immunohistochemical localization of Ki67. Materials and Methods:Thirty young adult male albino rats with body weight ranged from 80-110 gram and of 2 month age were used and divided into the following groups. Group I (control group): Consisted of 20 rats, subdivided into 2 subgroups. Group I.1:10 animals were sacrificed after one month to serve as young controls. Group I.2:10 animals were left till the end of the experiment to serve as old controls. Group II: 10 animals received Selenium 150 µg/kg diet for the whole experimental period. The experiment lasted for 9 months.Results: histological results revealed that aging caused devastating effects on the histological structure of submandibular and sublingual salivary glands. Selenium markedly modulated the action of aging process and increased the regenerative capacity of submandibular and sublingual glands. According to expression intensity of Ki67 stain in submandibular and sublingual glands, there was statistically significant difference between young, selenium and old groups. In general, expression intensity of Ki67 stain was the highest in the young control group followed by selenium group and lowest in old control group. Also, ki67 expression was significantly higher in sublingual than submandibular glands. Conclusions:Selenium was documented to have a powerful and beneficial antiaging effect. This faced lights around the promising role of selenium in the new era of regenerative medicine. Sublingual gland was more resistant to regressive changes of aging than submandibular gland.

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“…The beneficial role of selenium was obvious in the dietary management of chronic metabolic diseases such a Hyperlipidaemia, Hyperglycemia and Hyperphenylalaninemia [29] .…”

Section: Discussionmentioning

confidence: 99%

Histological and Immunohistochemical Study of Selenium Regenerative Effect on Submandibular and Sublingual Glands of Aging Rats

Elsaied

2019

Egyptian Dental Journal

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“…Se is a supplement that plays an important role in human's health. The given Se intake is expected to be able to prevent the increase of antioxidants SOD and GPx as well as provide with potential hope as a therapy to prevent cell damage caused by exposure to e-cigarette [31].…”

Section: Discussionmentioning

confidence: 99%

The Role of Selenium Micronutrients as Antioxidants in Exposure to E-Cigarette Smoke

Suryadinata

Adriani

Martini

et al. 2019

Asian J Pharm Clin Res

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Objective: E-cigarette products have resulted in various controversies concerning their posed impacts on health. Some argue that exposure to e-cigarette smoke could improve free radicals in the body; thus, it causes harming impacts on health. Peroral selenium (Se) administration can increase superoxide dismutase (SOD) and glutathione peroxidase (GPx) serving as antioxidants in the body. Methods: This research is an experimental study aiming to analyze the effectiveness of Se to decrease free radical due to exposure to e-cigarette smoke as one of the preventive actions. The research was carried out to male Wistar rats with exposure to e-cigarette smoke and peroral Se intake with different time and duration of administration. Results: Research results showed a decrease of antioxidant SOD and GPx in the administration of exposure to e-cigarette smoke, and they gradually increased after Se administration (p=0.000). Meanwhile, the malondialdehyde level was inversely proportional compared to antioxidant SOD and GPx. Conclusion: Se is a micronutrient that can reduce free radicals due to exposure to e-cigarette smoke through enhancement of antioxidant enzymes such as SOD and GPx.

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“…Esansiyel mikro besin ögesi olan selenyum, doku ve membranları oksidatif hasara karşı koruyan selenoproteinlerin anahtar bileşenidir. 80 Selenyumun in vivo ve in vitro çalışmalarda insülin duyarlılığını artırdığı saptanmıştır. 81 Ayrıca, birçok çalışmada selenyumun insülin benzeri etki gösterdiği bildirilmiştir.…”

Section: Selenyum Ve Di̇abetes Melli̇tusunclassified

Minerals and Diabetes Mellitus

Gülbaran¹,

Çelik²

2019

Turkiye Klinikleri J Intern Med

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gibi birtakım minerallerin dolaşımdaki seviyeleri diyabet için önemli bir prediktör olabilmekte ve suplementasyonları diyabetik bireylerin sağlık durumlarında yararlı etkiler oluşturabilmektedir. Glukoz homeostazı pankreasın beta hücrelerinden salgılanan insülin hormonunun kontrolü ve koordinasyonu ile sağlanmaktadır. Vücuttaki insülinin üretilememesi veya kullanılamaması durumunda kan glukoz homeostazında bozulmalar meydana gelmekte ve vücuttan bazı minerallerin aşırı atılımı gerçekleşebilmektedir. Aşırı atılım ile gereksinimin artması sonucu glukoz metabolizma yolağında, beta hücre fonksiyonunda ve insülin sinyalizasyon kaskadında bozulmalar meydana gelebilmekte ve bu durum diyabet ve komplikasyonlarının patogenezine katkı sağlayabilmektedir. Bu çalışmada, bazı minerallerin vücuttaki seviyelerinin ve yapılan süplementasyonların diyabet ile ilişkisinin değerlendirilmesi amaçlanmıştır. Bu noktada, odaklandığımız mineraller; çinko, bakır, krom, magnezyum, mangan, bakır, demir, selenyum ve vanadyumdur. Yapılan çalışmalardan elde edilen sonuçlar, vücut mineral düzeyinin diyabet ile ilişkisinde bazı farklılıklar ortaya koymaktadır. Ayrıca, diyabetin önlenmesi veya yönetiminde mineral süplementasyonunun yeterli kanıtlar sağlayamadığını göstermektedir. Diyabet ve komplikasyonları açısından risk altında olan bireylerde dolaşımdaki mineral düzeyinin ve mineral süplementasyonun gerekliliğinin saptanması oldukça önemlidir ve bu noktada daha büyük örnekli ve daha uzun süreli takip gerektiren çalışmalarla desteklenen kanıtlara gereksinim duyulmaktadır.A An na ah ht ta ar r K Ke el li im me el le er r: : Mineraller; diabetes mellitus; kan glukozu A AB BS ST TR RA AC CT T Minerals take an important role in electrolyte balance, preservation and maintenance of bone tissue, blood clotting, and regulation of nerve conduction as well as role as enzyme cofactor in various physiological reactions in metabolism. Circulating levels of a number of minerals, such as zinc, chromium, magnesium, manganese, selenium, may be an important predictor for diabetes, and their supplementation may have beneficial effects on the health status of diabetic individuals. Glucose homeostasis is provided by the control and coordination of insulin hormone secreted from beta cells of the pancreas. In the event that the insulin in the body cannot be produced or used, disruption of blood glucose homeostasis occurs and excessive excretion of some minerals from the body may occur. As a result of increased requirement with excessive excretion, in the glucose metabolism pathway, in beta-cell function and insulin signaling cascade may occur impairments and this occasion may contribute to the pathogenesis of diabetes and its complications. The aim of this review evaluate the relationship between levels and/or supplement of minerals and diabetes mellitus. At this point we focus on zinc, copper, chromium, magnesium, manganese, copper, iron, selenium and vanadium. The results obtained from the studies show some differences in the relationship of body mineral level and ...

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Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

Cited by 221 publications

References 125 publications

Histological and Immunohistochemical Study of Selenium Regenerative Effect on Submandibular and Sublingual Glands of Aging Rats

Histological and Immunohistochemical Study of Selenium Regenerative Effect on Submandibular and Sublingual Glands of Aging Rats

The Role of Selenium Micronutrients as Antioxidants in Exposure to E-Cigarette Smoke

Minerals and Diabetes Mellitus

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