Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets

Li, Dong; Zhong, Xiang; He, Jun; Zhang, Lili; Bai, Kaiwen; Xu, Wen; Wang, Tian; Huang, Xin

doi:10.1016/j.clnu.2015.03.002

Cited by 103 publications

(93 citation statements)

References 21 publications

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“…Not It is supposed that dietary high-SBM inclusion caused the damage of intestine morphology structure, decrease in digestion enzyme activities (Liu et al, 2019) and nutrient absorption (Buttle et al, 2001;Olli, Hjelmeland, & Krogdahl, 1994;Refstie, Storebakken, & Rorm, 1998;Storebakken et al, 1999) and eventually the poor growth performance. The supplementation of tributyrin at 0.1% and 0.2% levels in SBM-based diets significantly improved fish growth performance, resulting in comparable values to that of fish fed the FM diet (Table 3), which is consistent with findings in poultry (Antongiovanni, Buccioni, Minieri, Galigani, & Rapaccini, 2010;Antongiovanni et al, 2007) and pigs (Dong et al, 2016;Hou, Liu, Hu, & Shen, 2006). However, a significant decrease in growth the major energy source of colonocyte epical cells (Hamer et al, 2010;Wong, De, Kendall, Emam, & Jenkins, 2006), butyric acid and butyrate have been administrated to promote the proliferation and differentiation of intestine villi epical cells, which subsequently increase intestine surface area, promoting the digestion and utilization of nutrients in mammalian and aquatic animal studies (Biagi et al, 2007;Claus, Günthner, & Letzquss, 2007;Gao, Trond, Karld, Michael, & Margareth, 2011;Liu et al, 2017Liu et al, , 2019Lu et al, 2008).…”

Section: Discussionsupporting

confidence: 85%

“…It is supposed that dietary high‐SBM inclusion caused the damage of intestine morphology structure, decrease in digestion enzyme activities (Liu et al, ) and nutrient absorption (Buttle et al, ; Olli, Hjelmeland, & Krogdahl, ; Refstie, Storebakken, & Rorm, ; Storebakken et al, ) and eventually the poor growth performance. The supplementation of tributyrin at 0.1% and 0.2% levels in SBM‐based diets significantly improved fish growth performance, resulting in comparable values to that of fish fed the FM diet (Table ), which is consistent with findings in poultry (Antongiovanni, Buccioni, Minieri, Galigani, & Rapaccini, ; Antongiovanni et al, ) and pigs (Dong et al, ; Hou, Liu, Hu, & Shen, ). However, a significant decrease in growth performance in fish fed the TB0.4 diet was observed, which may be due to the significant decrease in FI of fish fed the TB0.4 diet ( p < .05).…”

Section: Discussionsupporting

confidence: 84%

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Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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Six equal‐protein and equal‐lipid diets were formulated: the fish meal (FM) diet, the soya bean meal (SBM) diet with 40% of FM protein replaced by SBM protein and tributyrin (TB) diets with 0.05% (TB0.05), 0.10% (TB0.1), 0.20% (TB0.2) and 0.40% (TB0.4) tributyrin supplemented in the SBM‐based diet. Each kind of diet was randomly fed to triplicate tanks with 20 fish per tank. Fish were fed apparent satiation twice daily for 56 days. No significant difference in weight gain rate (WGR) and feed efficiency rate (FER) was observed between fish fed the FM, TB0.1 and TB0.2 diets (p > .05). Muscle histidine and arginine proportion of fish fed TB0.1 diet was significantly higher than that of fish fed the SBM diet (p < .05). Intestine morphology results indicated that the supplementation of 0.1% tributyrin significantly improved the mucosal fold height, microvilli length and microvilli density when compared with those of fish fed the SBM diet (p < .05). The supplementation of dietary tributyrin suppressed the pro‐inflammatory gene expression, which may be due to the improvement of physical barrier and modification of microbial communities, such as Acinetobacter, Rhodocyclaceae, Brevundimonas, Sphingopyxis, Hydrogenophaga, Methyloversatilis and Devosia. In conclusion, dietary 0.1% tributyrin supplementation in high‐soya bean meal diet improved growth performance, flesh quality and intestinal morphology structure integrity of yellow drum.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 84%

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tan

Zhu

et al. 2020

Aquac Res

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“…According to our results, protease, lipase (foregut and midgut) and amylase (foregut) activities were significantly increased in the fish fed the TB‐supplemented diets. A study in pigs found that adding TB to the diet did not only facilitate the activation of lactase, sucrase, maltase, lipase and trypsin in the ileum but also improved the activity of lactase, sucrase and lipase in the duodenum (Dong et al, ). Hou et al () also found an increase in lactase activity in the duodenum and ileum and maltase activity in the ileum after supplementing their diet with TB.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, more butyrate molecules can be released in the intestine where they exert their functions. Several studies have been conducted in which TB supplementation was used in various terrestrial animals, such as piglets (Dong et al, ; Hou, Liu, Hu, & Shen, ), small tail ewes (Ren et al, ) and broilers (Antongiovanni et al, ; Li et al, ; Lum et al, ). The results of these studies were consistent and demonstrated that TB promotes growth performance and maintains normal intestinal morphology of animals.…”

Section: Introductionmentioning

confidence: 99%

Tributyrin‐supplemented high‐soya bean meal diets of juvenile black sea bream, Acanthopagrus schlegelii : Study on growth performance and intestinal morphology and structure

et al. 2019

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An 8‐week growth trial was conducted to evaluate the effects of different levels of tributyrin supplementation in a high‐soya bean meal diet on juvenile black sea bream (11.30 ± 0.16 g). The positive control (PC) diet contained 45% fishmeal and 20% soya bean meal, while the negative control (NC) contained 12% fishmeal and 45% soya bean meal. Graded levels of tributyrin were added to the NC diet at 0.05% (TB 0.05), 0.1% (TB 0.1), 0.2% (TB 0.2), 0.4% (TB 0.4) and 0.8% (TB 0.8). Ultimately, the fish fed the PC diet had a higher weight gain and specific growth rate than the fish fed other diets. The fish fed the NC diet had the lowest growth, and TB 0.05–TB 0.2 diets increased growth performance while TB 0.4–TB 0.8 diets caused reduction in growth. Dietary tributyrin supplementation improved protease activity and enhanced antioxidant capacity. Compared with the fish fed the NC diet, the fish fed the tributyrin‐supplemented diets had improved gut morphology and structure, and the results were similar to those of the fish fed the PC diet. Furthermore, the analysis of the dose response with second‐order polynomial regression indicated that the optimum tributyrin supplementation for juvenile black sea bream is 2.24 g/kg in the 45% soya bean meal diet.

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“…For example, IUGR animals generally have a reduced neonatal survival rate, gut dysfunction, a low efficiency of nutrient utilization and postnatal long-term growth limitation (Wu et al 2006). Previous studies confirmed that the impaired development and functions of the intestine in IUGR piglets result from changes in the developmental pattern of the intestinal structure, and transcriptomic and proteomic profiles (Wang et al 2008;D'Inca et al 2011;Dong et al 2016).…”

Section: Introductionmentioning

confidence: 97%

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

Zhang

Xie

et al. 2019

J of Applied Microbiology

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Aim Intrauterine growth retardation (IUGR) is a prevalent problem in mammals. The present study was conducted to unveil the alterations in intestinal microbiota in IUGR piglets. Methods and Results We identified the alterations of small intestinal microbiota in IUGR piglets on 7, 21 and 28 days of age using 16S rRNA sequencing. The results showed that IUGR piglets had a decreased alpha diversity of jejunum microbiota at 7 and 21 days of age; had lower abundances of Bacteroidetes and Bacteroides in the jejunum at 7, 21 and 28 days of age, Oscillibacter in the jejunum at 21 days of age, and Firmicutes in the ileum at 21 days of age; whereas they had higher abundances of Proteobacteria and Pasteurella in the ileum at 21 days of age and Escherichia–Shigella in the jejunum at 28 days of age. Correlation analysis showed that Bacteroides, Oscillibacter and Ruminococcaceae_UCG‐002 compositions were positively associated with the body weight (BW) of IUGR piglets, nevertheless Proteobacteria and Escherichia–Shigella relative abundances were negatively correlated with the BW of IUGR piglets. Gene function prediction analysis indicated that microbiota‐associated carbohydrate metabolism, lipid metabolism, glycan biosynthesis and metabolism, amino acid metabolism, and xenobiotics biodegradation and metabolism were downregulated in the IUGR piglets compared to control piglets. Conclusions The present study profiled the intestinal microbiota of newborn piglets with IUGR and the newborn IUGR piglets have lower diversity and different taxonomic abundances. Alterations in the abundances of Bacteroidetes, Bacteroides, Proteobacteria Escherichia–Shigella and Pasteurella may be involved in nutrient digestion and absorption, as well as the potential mechanisms connecting to the growth and development of IUGR in mammals. Significance and Impact of the Study The small intestinal microbiota were highly shaped in the IUGR piglets, which might further mediate the growth and development of IUGR piglets; and the gut microbiota could serve as a potential target for IUGR treatment.

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Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets

Cited by 103 publications

References 21 publications

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (Nibea albiflora)

Tributyrin‐supplemented high‐soya bean meal diets of juvenile black sea bream, Acanthopagrus schlegelii : Study on growth performance and intestinal morphology and structure

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

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