Supplementation of zinc mitigates the altered uptake and turnover of 65Zn in liver and whole body of diabetic rats

Pathak, Ashima; Sharma, Vishawjyoti; Kumar, Sanjeev; Dhawan, D. K.

doi:10.1007/s10534-011-9461-2

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…Therefore, in conditions of arsenic toxicity, the mobilization of metallothioneins from liver and other tissues would result in decreased levels of zinc in systemic circulation. Similar observation had been reported from our laboratory indicating increased mobilization of metallothioneins leading to decreased levels of zinc in blood (Pathak et al, 2011). Further, zinc levels were restored to within normal range when zinc was supplemented along with the arsenic, thereby substantiating induction of metal binding proteins and containment of reactive oxygen species (Chadha et al, 2008).…”

Section: Discussionsupporting

confidence: 91%

Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Bhardwaj

Dhawan

2019

Toxicol Ind Health

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The aim of this study was to understand the effects of zinc supplementation on antioxidant defense systems, hematological indices, and erythrocyte morphology in conditions of chronic arsenic toxicity. Male Wistar rats were segregated into four groups: control, arsenic treated, zinc supplemented, and arsenic + zinc treated. The animals in the arsenic-treated group were given arsenic orally in drinking water in the form of sodium arsenite at a dose level of 100 mg L−1, and zinc was administered to zinc-treated animals in the form of zinc sulfate orally in drinking water at a dose level of 227 mg L−1. The animals were subjected to different treatments for a period of 12 weeks, and various investigations were undertaken that included serum zinc content, activity of antioxidant enzymes, and hematological indices. Further, scanning electron microscopic (SEM) studies were performed to assess morphological changes in erythrocytes. Arsenic treatment significantly reduced serum zinc concentrations, which, however, were restored to near-normal levels upon zinc supplementation. The activities of enzymes involved in antioxidant defense systems were altered in the erythrocyte lysates of arsenic-treated rats, which interestingly revealed a significant improvement upon simultaneous zinc supplementation. A significant reduction in the counts of total leukocytes, neutrophils, and lymphocytes was observed following arsenic intoxication, which came back to near control levels following zinc supplementation. Also, protective effects of zinc were evident from SEM that revealed maintenance of topographical appearances of erythrocytes in conditions of arsenic toxicity. Thus, this study clearly shows the protection afforded by zinc on erythrocytes during arsenic-induced toxicity.

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Section: Discussionsupporting

confidence: 91%

Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Bhardwaj

Dhawan

2019

Toxicol Ind Health

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“…Anti-oxidant properties of Zinc have been evaluated in-vitro , as well as in-vivo animal and human studies. Hypozincaemia and hyperzincuria is known to be present in patients with both type-1 and type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal [ 11 , 19 – 21 ]. Plasma Thiobarbituric acid reactive substances (TBARS), a marker of oxidative stress is high in both type-1 and type-2 diabetic patients, and significantly decreased by supplementation of Zinc 30 mg/day for 3–6 months [ 11 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications

et al. 2015

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BackgroundDiabetes mellitus is a leading cause of morbidity and mortality worldwide. Studies have shown that Zinc has numerous beneficial effects in both type-1 and type-2 diabetes. We aim to evaluate the literature on the mechanisms and molecular level effects of Zinc on glycaemic control, β-cell function, pathogenesis of diabetes and its complications.MethodsA review of published studies reporting mechanisms of action of Zinc in diabetes was undertaken in PubMed and SciVerse Scopus medical databases using the following search terms in article title, abstract or keywords; (“Zinc” or “Zn”) and (“mechanism” or “mechanism of action” or “action” or “effect” or “pathogenesis” or “pathology” or “physiology” or “metabolism”) and (“diabetes” or “prediabetes” or “sugar” or “glucose” or “insulin”).ResultsThe literature search identified the following number of articles in the two databases; PubMed (n = 1799) and SciVerse Scopus (n = 1879). After removing duplicates the total number of articles included in the present review is 111. Our results show that Zinc plays an important role in β-cell function, insulin action, glucose homeostasis and the pathogenesis of diabetes and its complications.ConclusionNumerous in-vitro and in-vivo studies have shown that Zinc has beneficial effects in both type-1 and type-2 diabetes. However further randomized double-blinded placebo-controlled clinical trials conducted for an adequate duration, are required to establish therapeutic safety in humans.Electronic supplementary materialThe online version of this article (doi:10.1186/s40199-015-0127-4) contains supplementary material, which is available to authorized users.

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“…Group III: Zinc treated. Rats in this group were supplemented with zinc in the form of zinc sulphate (ZnSO 4 .7H 2 O) at a dose of 227mg/L added to the drinking water of the animals [7]. Group IV: Zinc and Ethanol treated.…”

Section: Methodsmentioning

confidence: 99%

“…Zinc is an essential micronutrient and plays an important role in maintaining intestinal epithelial integrity [6]. It plays a key role in body's defenses against free radicals and reactive oxygen molecules as constituents of antioxidant enzymes [7]. Alcoholics frequently show zinc deficiency [8] that produces several pathological disorders both in laboratory animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Role of Zinc on Ethanol Metabolism in Intestine of Alcohol Intoxicated Rats

2014

International Conference on Biological, Chemical and Environmental Sciences (BCES-2014) June 14-15, 2014 Penang (Malaysia)

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There has been escalation in alcohol abuse with an enormous increase in alcohol-related gastrointestinal tract disorders. The study was conducted to evaluate the role of zinc on intestine of rats under ethanol toxicity. Rats were segregated into four groups: Control, Ethanol treated, Zinc treated and Combined zinc and ethanol treated. 1ml of 30% ethanol was given to rats orally everyday. Zinc (as zinc sulphate; 227mg/L) was mixed in drinking water of animals. All treatments were given for 2, 4 and 8 weeks and activities of drug metabolising enzymes i.e Cytochrome P450, Cytochrome b 5 , NADPH and NADH cytochrome-C-reductase and Glutathione-s-transferase were estimated. Significant elevation was observed in the activities of all enzymes in intestine in response to toxicity induced by ethanol after all intervals. Zinc supplementation resulted in normalization of these values. This may be due to its antioxidant potential which provides protection against the toxic effects of ethanol.

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Supplementation of zinc mitigates the altered uptake and turnover of 65Zn in liver and whole body of diabetic rats

Cited by 14 publications

References 32 publications

Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications

Role of Zinc on Ethanol Metabolism in Intestine of Alcohol Intoxicated Rats

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