Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Bhardwaj, Pradeep; Dhawan, D. K.

doi:10.1177/0748233719878563

Cited by 10 publications

(9 citation statements)

References 54 publications

(63 reference statements)

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“…[37] e observed reduced heme level in the exposed GDs may be corroborative of the combined (synergistic adverse) effects of reduced Fe and Zn levels in the exposed workers. is appears to support earlier reports [38] in which there were decreased Fe concentrations in patients with acute myelogenous leukemia as well as acute lymphoblastic leukemia. e inverse correlation between urinary phenol and heme albeit not significant, may suggest a trend in the deleterious effects of metabolites of benzene on the haemopoietic system.…”

Section: Discussionsupporting

confidence: 91%

“…Evidence from animal models as well as from some human studies have shown that tumors contain high concentrations of Cu. [38] In contrast, this study showed a significantly lower serum Cu level in our study population than that of the unexposed. is finding also contradicts the report of some other investigators.…”

Section: Discussioncontrasting

confidence: 86%

“…is finding also contradicts the report of some other investigators. [38] is discrepancy may reflect the degree or strength of the toxic metabolites generated in this study and demand for the bioavailability of Cu for protective mechanisms to mitigate the unfolding toxicity as enunciated below. e observed low serum Cu level in our study may reflect increased demand for Cu considering its role as an important antioxidant component of Cu, Zn-SOD and equally its involvement with ceruloplasmin as ferroxidase in an attempt to obtain more Fe bound to transferrin for ineffective erythropoiesis in a toxic metabolite burdened marrow.…”

Section: Discussionmentioning

confidence: 97%

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Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Anetor

Adigun

Bolajoko

et al. 2022

AJBPS

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Objectives: There is increasing exposure to petrochemicals, including benzene, particularly in the low and medium-income countries. Benzene is a component of many petrochemicals and a ubiquitous environmental pollutant. Phenol is one of its principal metabolites and serves as a biomarker of exposure to benzene. The mechanism of its toxicity is incompletely elucidated. Benzene’s interaction with key micronutrients; copper (Cu), iron (Fe), and zinc (Zn) in the haemopoietic system has only been poorly explored, particularly in the developing countries where their status is variable and uncertain, with attendant intense exposure to petrochemicals. Material and Methods: Two groups of 50 gasoline dispensers (GDs) and 50 non-occupationally exposed participants were selected from Oye Local Government Area, Nigeria. The duration of occupational exposure was 2–10 years. Serum levels of Cu, Fe, and Zn were determined using flame atomic absorption spectrophotometry while heme and phenol were determined by standard spectrophotometry. Results: Phenol was significantly higher in GDs (P = 0.000), compared to controls (P < 0.05). The micronutrients, Cu, Fe, and Zn were all significantly decreased in GDs compared to controls (P = 0.000 in all cases). Phenol and Fe demonstrated significant inverse correlation (r = −0.557, P = 0.00), while heme and Zn also exhibited inverse correlation respectively to phenol (r = −0.38, P = 0.01; r = −0.37, P = 0.01). Conclusion: These data suggest intense perturbation of the haemopoietic system in GDs; likely from altered xenobiotic metabolism requiring heme in cytochrome P450; cell cycle dysregulation, where Zn is pivotal, p53 suppression also dependent on Zn and oxidative stress all converging in haemopoietic dysregulation. Importantly, depression of these micronutrients implies potentiation of myelotoxicity and risk of myeloproliferation, probably arising from alterations in transcription, differentiation errors, genome instability, and derangement in cell signal transduction moderated by Zn; accentuating risk of myeloproliferation; suggesting a role for these micronutrients in chemoprevention. Understanding these events may be important in risk assessment, policy formulation, regulatory measures and chemoprevention in GDs and the general population.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 97%

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Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Anetor

Adigun

Bolajoko

et al. 2022

AJBPS

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“…Some medicines of plant origin are known to be activators of the Nfr2 action . Treatment with Zn during gestation and lactation developed a protective effect in As-induced (5 mg/kg/day as sodium meta-arsenite) oxidative stress in rats' renal tissue, which was confirmed by the improvement of the malondialdehyde (MDA) and GSH levels, also as the histopathological changes (Bhardwaj and Dhawan 2019). Zinc improved renal antioxidant status in rats in the models of cyclosporine-and mercuric chloride-induced kidney damage (Ghabaee et al 2017).…”

Section: Natural Products As Promising Chelating and Detoxifying Agenmentioning

confidence: 96%

Arsenic intoxication: general aspects and chelating agents

et al. 2020

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Arsenic (As) is widely used in the modern industry, especially in the production of pesticides, herbicides, wood preservatives, and semiconductors. The sources of As such as contaminated water, air, soil, but also food, can cause serious human diseases. The complex mechanism of As toxicity in the human body is associated with the generation of free radicals and the induction of oxidative damage in the cell. One effective strategy in reducing the toxic effects of As is the usage of chelating agents, which provide the formation of inert chelator-metal complexes with their further excretion from the body. This review discusses different aspects of the use of metal chelators, alone or in combination, in the treatment of As poisoning. Consideration is given to the therapeutic effect of thiol chelators such as meso-2,3-dimercaptosuccinic acid, sodium 2,3-dimercapto-1-propanesulfonate, 2,3-dimercaptopropanol, penicillamine, ethylenediaminetetraacetic acid, and other recent agents against As toxicity. The review also considers the possible role of flavonoids, trace elements, and herbal drugs as promising natural chelating and detoxifying agents.

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“…The heart tissue of common carp exposed to iAs revealed reduced oxidative stress (through decreased production of reactive oxygen species and increased activity of antioxidant enzymes), lipid peroxidation (through decreased content of malondialdehyde), apoptosis (through increased expression of Bcl-2 and decreased expression of Bax and caspases), autophagy (by decreasing the level of proteins involved in the previously mentioned pathways), and injury symptoms [60]. In rats exposed to iAs, zinc supplementation reduced the damage to erythrocytes, mediated through the increased activity of antioxidant enzymes, decreased lipid peroxidation in the serum, and decreased morphological changes in red blood cells [61].…”

Section: Kumar Andmentioning

confidence: 99%

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I—Animal Model Studies

Sijko

Kozłowska

2021

Toxics

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Population and laboratory studies indicate that exposure to various forms of arsenic (As) is associated with many adverse health effects; therefore, methods are being sought out to reduce them. Numerous studies focus on the effects of nutrients on inorganic As (iAs) metabolism and toxicity, mainly in animal models. Therefore, the aim of this review was to analyze the influence of methionine, betaine, choline, folic acid, vitamin B2, B6, B12 and zinc on the efficiency of iAs metabolism and the reduction of the severity of the whole spectrum of disorders related to iAs exposure. In this review, which includes 58 (in vivo and in vitro studies) original papers, we present the current knowledge in the area. In vitro and in vivo animal studies showed that methionine, choline, folic acid, vitamin B2, B12 and zinc reduced the adverse effects of exposure to iAs in the gastrointestinal, urinary, lymphatic, circulatory, nervous, and reproductive systems. On the other hand, it was observed that these compounds (methionine, choline, folic acid, vitamin B2, B12 and zinc) may increase iAs metabolism and reduce toxicity, whereas their deficiency or excess may impair iAs metabolism and increase iAs toxicity. Promising results of in vivo and in vitro on animal model studies show the possibility of using these nutrients in populations particularly exposed to As.

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Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

Cited by 10 publications

References 54 publications

Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Arsenic intoxication: general aspects and chelating agents

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I—Animal Model Studies

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