Supplemented Use of Pre-, Pro-, and Synbiotics in Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis of 13 Randomized Controlled Trials

Tian, Xu; Pi, Yuan-Ping; Liu, Xiaoling; Chen, Hui; Chen, Weiqing

doi:10.3389/fphar.2018.00690

Cited by 25 publications

(15 citation statements)

References 54 publications

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“…A recent meta-analysis of 13 randomized controlled trials showed a beneficial impact of microbial regulation on SAP patients by reducing the length of hospital stays. 19 Other studies in animal models also showed that improvements in the gut microbiota or supplementation with its metabolites ameliorated pancreatic injury by maintaining gut homeostasis. [20][21][22][23] Here, we observed that depletion of the gut microbiota reduced pancreatic damage and suppressed the systemic inflammatory response, while FMT reversed this process.…”

Section: Discussionmentioning

confidence: 99%

The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice

et al. 2020

Gut Microbes

102

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Early dysbiosis of the gut microbiota is associated with the severity of acute pancreatitis (AP), although the underlying mechanism is unclear. Here, we investigated the role of crosstalk between NLRP3 and the gut microbiota in the development of AP utilizing gut microbiota deficient mice, as well as NLRP3 knockout (KO) mouse models. Pancreatic damage and systemic inflammation were improved in antibiotic-treated (Abx) and germ-free (GF) mice, accompanied by weakened activity of the intestinal NLRP3 inflammasome. Interestingly, fecal microbiota transplantation (FMT) reactivated the intestinal NLRP3 inflammasome and exacerbated the disease in Abx and GF mice. Although the gut barrier in GF and Abx mice was disrupted, gut microbiota deficiency ameliorated the severity of AP, probably due to the reduction in bacterial translocation from the gut to the pancreas. The composition of the gut microbiota was significantly different between NLRP3 KO mice and wild-type (WT) mice at baseline, and there were alterations in response to the induction of AP. While a dramatic shift in the gut microbiota with overgrowth of Escherichia-Shigella was observed in WT mice suffering from AP, there was no significant change in NLRP3 KO mice with or without AP, suggesting that NLRP3 deficiency counteracts AP-induced microbial disturbance. With a strengthened gut barrier and decreased systemic inflammation, NLRP3 KO mice showed less severe AP, as revealed by reduced pancreatic neutrophilic infiltration and necrosis. Taken together, these results identified the bidirectional modulation between the gut microbiota and NLRP3 in the progression of AP, which suggests the interplay of the host and microbiome during AP.

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Section: Discussionmentioning

confidence: 99%

The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice

et al. 2020

Gut Microbes

102

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“…The development of synbiotics is emerging to be of paramount importance as it can be used as a supplement in food and nutraceutical applications. Nutraceuticals can be used as dietary supplements or functional foods, as they are food ingredients or sourced from food products that, apart from the basic original nutritional value, provide extra benefits (e.g., chronic disease prevention, improving health) [263,264,265].…”

Section: Development Of Synbioticsmentioning

confidence: 99%

Probiotics in Food Systems: Significance and Emerging Strategies Towards Improved Viability and Delivery of Enhanced Beneficial Value

et al. 2019

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Preserving the efficacy of probiotic bacteria exhibits paramount challenges that need to be addressed during the development of functional food products. Several factors have been claimed to be responsible for reducing the viability of probiotics including matrix acidity, level of oxygen in products, presence of other lactic acid bacteria, and sensitivity to metabolites produced by other competing bacteria. Several approaches are undertaken to improve and sustain microbial cell viability, like strain selection, immobilization technologies, synbiotics development etc. Among them, cell immobilization in various carriers, including composite carrier matrix systems has recently attracted interest targeting to protect probiotics from different types of environmental stress (e.g., pH and heat treatments). Likewise, to successfully deliver the probiotics in the large intestine, cells must survive food processing and storage, and withstand the stress conditions encountered in the upper gastrointestinal tract. Hence, the appropriate selection of probiotics and their effective delivery remains a technological challenge with special focus on sustaining the viability of the probiotic culture in the formulated product. Development of synbiotic combinations exhibits another approach of functional food to stimulate the growth of probiotics. The aim of the current review is to summarize the strategies and the novel techniques adopted to enhance the viability of probiotics.

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“…At present, probiotics are mainly used to treat diarrhea, constipation, enteritis, abdominal distension, dyspepsia, and loss of appetite caused by intestinal flora imbalance. Some studies[ 10 , 19 ] suggested that probiotics were associated with decreased LOS, but these reports were of low quality and included a small sample of patients with severe acute pancreatitis. Besselink et al [ 8 ] conducted a study with the largest sample size of 298 randomized patients with severe acute pancreatitis; they found that probiotic prophylaxis did not reduce the risk of infectious complications and was associated with an increased risk of mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, a meta-analysis involving six trials with 536 patients showed that probiotics supplementation did not significantly affect the pancreatic infection rate, LOS, or mortality[ 9 ]. In contrast, another meta-analysis showed reduced LOS in Chinese patients with severe acute pancreatitis[ 10 ]. However, the effect of probiotics in mild acute pancreatitis has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Effect of probiotics on length of hospitalization in mild acute pancreatitis: A randomized, double-blind, placebo-controlled trial

Wan

Bian

Sun

2021

WJG

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Supplemented Use of Pre-, Pro-, and Synbiotics in Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis of 13 Randomized Controlled Trials

Cited by 25 publications

References 54 publications

The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice

The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice

Probiotics in Food Systems: Significance and Emerging Strategies Towards Improved Viability and Delivery of Enhanced Beneficial Value

Effect of probiotics on length of hospitalization in mild acute pancreatitis: A randomized, double-blind, placebo-controlled trial

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