Purpose: This study explores how manufacturing enterprises can effectively promote digital transformation through employee empowerment with ability, motivation, and opportunity empowerment at different stages.Design/methodology/approach: Drawing on ability, motivation, and opportunity (AMO) theory, this qualitative research takes the Jiangsu Shangshang Cable Group as a typical case to discuss manufacturing enterprises’ evolving employee empowerment model. Gioia structured data analysis method was adopted to analyse the data.Findings/results: In the stage of information technology (IT) application, the main task of employee empowerment is strengthening the employees’ abilities (‘can do’) and motivation (‘want to do’) by training their IT knowledge and skills, changing their mindset towards IT application, and letting them experience the efficiency of the latter. In the intelligence manufacturing stage, training employees to do better is the core content of employee empowerment. Enterprises can strengthen employees’ intelligent manufacturing skills, practice data-based performance appraisal and salary management, and let employees participate in intelligent manufacturing. In the stage of digital transformation of the whole process, employees are required to ‘do their best in the long run’. Enterprises could improve employee collaboration capabilities, build growth mechanisms, and involve every employee in innovation.Practical implications: In the digital transformation process, manufacturing enterprises could empower employees according to the different goals and requirements in the three stages of IT application, intelligence manufacturing, and digital transformation of the whole process. It has reference value for manufacturing enterprises to achieve digital transformation.Originality/value: This study explores a three-dimensional evolving employee empowerment model to promote manufacturing enterprises’ digital transformation.