Suppression of age-related renal changes in NF-κB and its target gene expression by dietary ferulate

Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate

“…The PI3K/Akt signaling pathway is activated by both oxidative stress and insulin. As mentioned earlier, ferulate suppressed increased oxidative stress in aged rats, as reported from our laboratory (Jung et al 2009). As shown in Fig.…”

“…The activation of phosphatidylinositol 3-kinase (PI3K)/Akt by ferulate has also been reported in HUVECs and breast cancer MCF7 cells (Chang et al 2006;Ma et al 2010b). Previously, we reported that ferulate effectively suppresses redox-sensitive, pro-inflammatory NFkappaB activation via NF-kappaB-inducing kinase/ IkappaB kinase and MAPKs by reducing oxidative stress in aged rats (Jung et al 2009). …”

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

“…Several of the characterized curcumin catabolites are antioxidants, including vanillin (Sawa et al, 1999;Maurya et al, 2007;Shyamala et al, 2007;Chou et al, 2010;Makni et al, 2011;Tai et al, 2011;Galano et al, 2012), vanillic acid (Sawa et al, 1999;Shyamala et al, 2007;Chou et al, 2010;Kumar et al, 2011;Prince et al, 2011;Stanely Mainzen Prince et al, 2011;Galano et al, 2012), ferulic acid (Scott et al, 1993;Kaul and Khanduja, 1998;Kanski et al, 2002;Kikuzaki et al, 2002;Hirata et al, 2005;Srinivasan et al, 2007;Jung et al, 2009), and 4-vinylguaiacol (Tressl et al, 1976). These catabolites may therefore elicit anticancer effects in various phases of cancer biology.…”

Contribution of Degradation Products to the Anticancer Activity of Curcumin

“…Firstly, the degradation products overcome the limitation of the extremely poor aqueous solubility for parent curcumin as reflected by their respective logP (1.42 for ferulic acid and 1.09 for vanillin, much lower than those of the keto and enol isomers of curcumin, 2.56 and 2.17). Secondly, the degradation products have been proved to exhibit anticancer potentials through inhibiting the important targets involved in the development of cancer (3)(4)(5). For instance, it was reported that ferulic acid can inhibit effectively both the cyclooxygenase-1 and cyclooxygenase-2 enzymes (3) and significantly suppress NF-κB activation (4).…”