Suppression of autoimmune disease by ω – 3 fatty acids

Robinson, Dwight R.; Knoell, Christopher T.; Urakaze, Masaharu; Huang, Ruyi; Taki, Hirofumi; Sugiyama, Eiko; Xu, Lin; Yeh, Eunice; Olesiak, W.; Guo, Meng; Colvin, R. B.; Auron, Philip E.

doi:10.1042/bst0230287

Cited by 29 publications

(22 citation statements)

References 1 publication

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“…Some FAs (e.g., n-3) are gen-erally considered beneficial for human health because of their immunosuppressive effects in some autoimmune and inflammatory diseases (10)(11)(12). The n-3 FAs eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (DHA; 22:6 n-3) cause a marked decrease in lymphocyte proliferation at 50 mM and promote an inhibition of cell cycle progression induced by IL-2 (9).…”

mentioning

confidence: 99%

Regulation of interleukin-2 signaling by fatty acids in human lymphocytes

Gorjão

Hirabara

Lima

et al. 2007

Journal of Lipid Research

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Docosahexaenoic (DHA; C22:6 n-3), eicosapentaenoic (EPA; C20:5 n-3), palmitic (PA; C16:0), and stearic (SA; C18:0) acids decrease lymphocyte proliferation in concentrations of .50 mM, as observed in our previous study. However, oleic acid (OA; C18:1 n-9) and linoleic acid (LA; C18:2 n-6) increase lymphocyte proliferation at 25 mM. In this study, the effect of these FAs on the interleukin-2 (IL-2) signaling pathway in human lymphocytes was investigated. Cells were isolated from heparinized venous blood of healthy human donors by density-gradient sedimentation. Cells were stimulated with 5 mg/ml concanavalin A and treated with FAs in the absence or presence of IL-2 for 1 hour. CD25-a externalization was analyzed by flow cytometry, and Janus kinase 1 ( JAK1), JAK3, signal transducer and activator of transcription (STAT) 5, extracellular signalregulated kinases (ERKs) 1 and 2, Akt, and protein kinase C (PKC)-Z phosphorylation were analyzed by Western blotting. The expression of CD25-a at the cell surface was increased by DHA, SA, and PA but was unaffected by EPA, OA, and LA. PA, SA, DHA, and EPA decreased JAK1, JAK3, STAT5, and Akt phosphorylation induced by IL-2, but OA and LA did not cause any effect. OA and LA increased ERK1/2 phosphorylation, whereas the other FAs caused a marked decrease. PKC-Z phosphorylation was decreased by OA and LA and was not altered by the remaining FAs. In conclusion, the inhibitory effect of PA, SA, DHA, and EPA on lymphocyte proliferation observed in our previous study was attributable to a decrease in JAK/STAT, ERK, and Akt pathways activated by IL-2. Probably, OA and LA stimulated lymphocyte proliferation by increasing ERK1/2 phosphorylation through PKC-Z activation. The inhibition of JAK1, JAK3, STAT5, ERK1/2, and Akt phosphorylation caused by DHA, SA, and PA is associated with an alteration of CD25 expression at the cell surface.-Gorjão, R., S. M. Hirabara, T. M. de Lima, M. F. Cury-Boaventura, and R. Curi. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. J. Lipid Res.

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confidence: 99%

Regulation of interleukin-2 signaling by fatty acids in human lymphocytes

Gorjão

Hirabara

Lima

et al. 2007

Journal of Lipid Research

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“…The same workers showed that dietary FO completely abolished mRNA production for IL-IP, IL-6 and TNF-a in the kidneys of theqe animals (Chandrasekar & Fernandes, 1994). Robinson et al (1995) reported that feeding mice on a FO-rich diet significantly diminished ex v i w 1L-1 p mRNA production by LPS-or PMA-stimulated spleen lymphocytes; the lower IL-I f3 mRNA level was not due to accelerated degradation but to impaired synthesis. FO feeding to mice lowered basal TNF-a mRNA and LPS-stimulated TNF-a and IL-I j 3 mRNA levels (Renier et nl.…”

Section: N-3 Polyunsuturatedjiztty Acids and Gene Expressionmentioning

confidence: 97%

Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

Calder

1996

Proc. Nutr. Soc.

138

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“…Diets containing 3:1 mixtures of EPA-E (eicosapentaenoic acid) and DHA-E alleviate renal disease in NZB=NZW (F 1 ) mice to a greater extent than either fatty acid singly. 13 Fish oil, but not corn oil, improves survival in NZB=NZW (F 1 ) B=W female mice. Fish oil supplementation reduces proteinuria and anti-dsDNA in NZBÂNZW (F 1 ) B=W mice.…”

Section: Fatty Acidsmentioning

confidence: 97%

Diet and systemic lupus erythematosus: from mouse and monkey to woman?

Petri

2001

Lupus

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Suppression of autoimmune disease by ω – 3 fatty acids

Cited by 29 publications

References 1 publication

Regulation of interleukin-2 signaling by fatty acids in human lymphocytes

Regulation of interleukin-2 signaling by fatty acids in human lymphocytes

Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

Diet and systemic lupus erythematosus: from mouse and monkey to woman?

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