Suppression of H-2b-associated resistance to Friend erythroleukemia virus by a class I gene from the H-2d major histocompatibility complex haplotype.

Polsky, David; Lilly, Frank

doi:10.1073/pnas.88.20.9243

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…Splenomegaly as a measure of Friend disease. Palpation for splenomegaly is the standard procedure used to monitor the progression of Friend disease (10,15,31) and was used in the following manner. At weekly intervals, each individual animal under general anesthesia was palpated in a blinded fashion and rated on a scale of 1ϩ to 4ϩ according to its spleen size.…”

Section: Methodsmentioning

confidence: 99%

Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms

Dittmer

Brooks

Hasenkrug

1998

J Virol

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Live-attenuated retroviruses have been shown to be effective retroviral vaccines, but currently little is known regarding the mechanisms of protection. In the present studies, we used Friend virus as a model to analyze characteristics of a live-attenuated vaccine in protection against virus-induced disease. Highly susceptible mice were immunized with nonpathogenic Friend murine leukemia helper virus (F-MuLV), which replicates poorly in adult mice. Further attenuation of the vaccine virus was achieved by crossing the Fv-1 genetic resistance barrier. The minimum dose of vaccine virus required to protect 100% of the mice against challenge with pathogenic Friend virus complex was determined to be 103 focus-forming units of attenuated virus. Live vaccine virus was necessary for induction of immunity, since inactivated F-MuLV did not induce protection. To determine whether immune cells mediated protection, spleen cells from vaccinated donor mice were adoptively transferred into syngeneic recipients. The results indicated that immune mechanisms rather than viral interference mediated protection.

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Section: Methodsmentioning

confidence: 99%

Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms

Dittmer

Brooks

Hasenkrug

1998

J Virol

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“…in cytomegalovirus-induced myocarditis (Lawson et al 1990). and in Friend virus-induced erythroleukemia (Polsky & Lilly 1991). Finally, in an animal model of human MHC-disease association, mice that are transgenic for the HLA-B27 allele are more susceptible to infection with Yersinia than are their nontransgenic Iittermates (Nickerson et al 1990).…”

Section: I) Many Mhc-disease Associations Involve Dominant or Co-domimentioning

confidence: 99%

A Genetic Herd‐Immunity Model for the Maintenance of MHC Polymorphism

Wills

Green

1995

Immunological Reviews

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“…This immunosuppressive effect of H-2 d is similar as for FV because the immunogenicity of the env gene is poor when presented in this context. It has been demonstrated that FV resistance is suppressed by the expression of genes located in the H-2D d region and that D d gene mediates at least in part its effects [30]. Our experiments with MHSV indicate that MHSV has similar properties but that the suppressive effect of the d haplotype probably maps to the left of the D region, that is, either in the K or I-A region.…”

Section: Depletion Of Cd4 ϩ Cells Results In An Increased Susceptibilmentioning

confidence: 56%

Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis

Panoskaltsis‐Mortari

Egeler

Yaeger³

et al. 1998

Journal of Leukocyte Biology

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Malignant histiocytosis sarcoma virus (MHSV) arose as a recombinant of c-Harvey-ras murine sarcoma virus (Ha-MuSV) and Friend mink cell focus-forming virus (F-MCFV). It is a defective acute transforming retrovirus that, along with Friend murine leukemia helper virus (F-MuLV), induces malignant histiocytosis (MH) in susceptible adult mice. We have assessed the in vivo susceptibility to MHSV in inbred homozygous, F1 hybrid, congenic, and recombinant inbred (RI) mice. We have shown that: (1) in vivo resistance to MHSV is multigenic, regulated by MHC and non-MHC genes in a different fashion than with F-MCFV, F-MuLV, or Ha-MuSV; (2) using BXD RI mice, the resistance phenotype is linked with 95.8% probability to two linked loci, Pmv-9 and Iapls3-14, on chromosome 13 (homologous to the area of human chromosome 5 for which a chromosomal break point at position 5q35 is associated with human MH); and (3) CD4+ T cells are critical for MHSV resistance.

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Suppression of H-2b-associated resistance to Friend erythroleukemia virus by a class I gene from the H-2d major histocompatibility complex haplotype.

Abstract: Mice homozygous for the H-2d haplotype at

Cited by 13 publications

References 28 publications

Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms

Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms

A Genetic Herd‐Immunity Model for the Maintenance of MHC Polymorphism

Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis

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