Suppression of lipopolysaccharide-induced expression of inflammatory indicators in RAW 264.7 macrophage cells by extract prepared fromGinkgo bilobacambial meristematic cells

Effect of Ginkgo biloba extract on the expressions of Cox-2 and GST-Pi in rats with hepatocellular carcinoma risk

“…Jang et al [29] found that Cox-2 expression in the cambial meristematic cells was almost completely suppressed by EGb. Bao et al [30] reported that EGb could inhibit the production of Cox-2 in myocardial ischemia/reperfusion rats.…”

Potentialities ofGinkgoextract on toxicants, toxins, and radiation: a critical review

“…Furthermore, one of these investigations by Jang et al 62 used a novel strategy to reduce environmentally related genomic changes in the extract by isolating GB stem cells as active components. Jang et al 62 cultured the GB root's cambial meristematic vascular stem cells and used a unique methodology to remove them using ethanol.…”

“…Furthermore, one of these investigations by Jang et al 62 used a novel strategy to reduce environmentally related genomic changes in the extract by isolating GB stem cells as active components. Jang et al 62 cultured the GB root's cambial meristematic vascular stem cells and used a unique methodology to remove them using ethanol. 62 As a result, GBE lowered Toll-like receptor-4 (TLR4) expression under LPS-related inflammation via tristetraprolin (TTP) and mitogen–activated protein kinase (MAPK) modulation and corroborated Lee et al 's 63 studies conducted on monocytes, and these effects were dependent on the duration of the exposure.…”

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

“…There are some experiments were carried out in order to clarify the effect of GB on LPS‐induced toxicity in mouse macrophage cells named RAW 264.7. Based on all these studies, totally, GB possesses notable antiinflammatory influences, which are at the transcriptional level and via NF‐κB/AP‐1, MAPKs, COX‐2/PGE2, and iNOS/NO pathways (Ilieva et al, ; Jang et al, ; Park et al, ; Ryu et al, ; Wadsworth & Koop, ; Wadsworth, McDonald, & Koop, ). An additional pathway has been shown by Ryu et al () that the increment activity and expression of HO‐1 as an antioxidant are mediated via the elevated level of its transcription factor, Nrf‐2.…”

“…Furthermore, a novel method was applied by one of these studies conducted by Jang et al () to minimize the environment‐dependent genomic variations in the extract content by isolating a kind of stem cells of GB plant as a generating source of active ingredients. They cultured the cambial meristematic cells of the GB roots, which are the vascular stem cells and prepared the ethanolic extraction of the cells with a special protocol (Jang et al, ).…”