Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols

Toyoda‐Ono, Yoshiko; Yoshimura, Mitsu; Nakai, Michikazu; Fukui, Yûkô; Asami, Sumio; Shibata, Hiroshi; Kiso, Yoshinobu; Ikeda, Ikuo

doi:10.1271/bbb.60635

Cited by 51 publications

(34 citation statements)

References 25 publications

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“…Interestingly, it has been proposed that polymerized polyphenols, which exert beneficial effect on lipid metabolism, are synthesized during oolong tea production. 45,46 As a processed green tea product, we speculate that FGT might also contain modified polyphenols derived from catechins, and we are now identifying those compounds. Future studies are needed to elucidate the detailed mechanisms and active components involved in FGT-mediated weight control.…”

Section: Discussionmentioning

confidence: 95%

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

Seo

Jeong

Cho

et al. 2015

Journal of Medicinal Food

110

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Obesity is caused by an imbalance between caloric intake and energy expenditure and accumulation of excess lipids in adipose tissues. Recent studies have demonstrated that green tea and its processed products (e.g., oolong and black tea) are introduced to exert beneficial effects on lipid metabolism. Here, we propose that fermented green tea (FGT) extract, as a novel processed green tea, exhibits antiobesity effects. FGT reduced body weight gain and fat mass without modifying food intake. mRNA expression levels of lipogenic and inflammatory genes were downregulated in white adipose tissue of FGT-administered mice. FGT treatment alleviated glucose intolerance and fatty liver symptoms, common complications of obesity. Notably, FGT restored the changes in gut microbiota composition (e.g., the Firmicutes/Bacteroidetes and Bacteroides/Prevotella ratios), which is reported to be closely related with the development of obesity and insulin resistance, induced by high-fat diets. Collectively, FGT improves obesity and its associated symptoms and modulates composition of gut microbiota; thus, it could be used as a novel dietary component to control obesity and related symptoms.

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Section: Discussionmentioning

confidence: 95%

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

Seo

Jeong

Cho

et al. 2015

Journal of Medicinal Food

110

View full text Add to dashboard Cite

show abstract

“…Green tea polyphenols show various beneficial functions such as anti-obesity [1], anti-HIV [2], [3], antioxidative [4], anti-cancer [5], anti-mutagenic [6], and hypocholesterolaemic activities [7]. In addition, oolong tea polymerised polyphenols (OTPP), which are polymers of catechins, have been reported to suppress postprandial hypertriglyceridaemia [8]. Lignin, a naturally occurring high-molecular weight phenolic compound, has also been shown to have anti-tumour, anti-influenza virus, anti-HIV, and anti-herpes simplex virus activities [9]–[11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Enzymatically Polymerised Polyphenols on CD4 Binding and Cytokine Production in Murine Splenocytes

Yamanaka¹,

Tamiya²,

Motoi³

et al. 2012

PLoS ONE

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High-molecular weight polymerised polyphenols have been shown to exhibit anti-influenza virus, anti-HIV, and anti-cancer activities. The purpose of this study was to evaluate the immunomodulating activities of enzymatically polymerised polyphenols, and to clarify the underlying mechanisms of their effects. The cytokine-inducing activity of the enzymatically polymerised polyphenols derived from caffeic acid (CA), ferulic acid (FA), and p-coumaric acid (CoA) was investigated using murine splenocytes. Polymerised polyphenols, but not non-polymerised polyphenols, induced cytokine synthesis in murine splenocytes. Polymerised polyphenols induced several cytokines in murine splenocytes, with interferon-γ (IFN-γ) and granulocyte-macrophage colony-stimulating factor (GM-CSF) being the most prominent. The underlying mechanisms of the effects of the polymerised polyphenols were then studied using neutralising antibodies and fluorescent-activated cell sorting (FACS) analysis. Our results show that polymerised polyphenols increased IFN-γ and GM-CSF production in splenocytes. In addition, the anti-CD4 neutralised monoclonal antibody (mAb) inhibited polymerised polyphenol-induced IFN-γ and GM-CSF secretion. Moreover, polymerised polyphenols bound directly to a recombinant CD4 protein, and FACS analysis confirmed that interaction occurs between polymerised polyphenols and CD4 molecules expressed on the cell surface. In this study, we clearly demonstrated that enzymatic polymerisation confers immunoactivating potential to phenylpropanoic acids, and CD4 plays a key role in their cytokine-inducing activity.

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“…Thus, prevention of obesity is an important strategy for avoiding metabolic syndrome (3). Some polyphenols, such as polymeric flavan-3-ols in oolong tea, exhibit anti-obesity effects to suppress lipid absorption from the small intestine (4). Green tea polyphenols, including epigallocatechin gallate, promote lipid metabolism (5).…”

mentioning

confidence: 99%

Boysenberry Polyphenols Suppressed Elevation of Plasma Triglyceride Levels in Rats

Mineo

Noguchi

Nagakura

et al. 2015

J Nutr Sci Vitaminol

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Summary Boysenberry, a hybrid Rubus berry, is mainly cultivated in New Zealand. We previously reported that consumption of boysenberry juice (BBJ) exhibited anti-obesity effects in high-fat feeding rats. In this study, we focused on the suppressive effect of BBJ and its fraction on triglyceride absorption from the gastrointestinal tract. BBJ effectively inhibited pancreatic lipase activity in vitro, and was separated into four fractions (Fr1, Fr2, Fr3 and Fr4) by HP-20 column chromatography. Among all the fractions, Fr3, the ellagic acid-rich fraction, showed the most potent inhibition against pancreatic lipase in vitro with Fr2, the anthocyanin-rich fraction, second. Authentic ellagic acid equivalent in Fr3 showed poor activity against pancreatic lipase. Then, each fraction was orally administered with corn oil to rats fitted with a jugular catheter to examine the effects of each fraction on plasma triglyceride levels. Both Fr2 and Fr3 effectively suppressed the plasma triglyceride level elevation at a dose of 1,000 mg/kg body weight. These findings demonstrated that BBJ contains chemical components which inhibit triglyceride absorption from the gastrointestinal tract.

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Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols

Cited by 51 publications

References 25 publications

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

The Effect of Enzymatically Polymerised Polyphenols on CD4 Binding and Cytokine Production in Murine Splenocytes

Boysenberry Polyphenols Suppressed Elevation of Plasma Triglyceride Levels in Rats

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