Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum

Dudhgaonkar, Shailesh; Thyagarajan, Anita; Slíva, Daniel

doi:10.1016/j.intimp.2009.07.011

Cited by 156 publications

(113 citation statements)

References 72 publications

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“…Macrophages are known to be one of the acute immune cells in the regulation of inflammatory responses. Activated macrophages secrete a number of inflammatory mediators [16]. In LPS-challenged RAW 264.7 macrophages, we found that ganoderol A could greatly inhibit the expression of LPS-induced pro-inflammatory molecules, including MCP-1 and iNOS.…”

Section: Discussionmentioning

confidence: 77%

In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties

Jin¹,

Zhao²,

Yuan³

et al. 2015

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 77%

In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties

Jin¹,

Zhao²,

Yuan³

et al. 2015

Trop. J. Pharm Res

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“…There was a low level of LPS contamination in the extract (1.1 ng/ml in oyster extract). This concentration of LPS was well below the level of LPS required to stimulate cells in vitro (20).…”

Section: Detection Of Lipopolysaccharides (Lps)mentioning

confidence: 79%

Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice

Sliva¹

2010

Int J Mol Med

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Abstract. Colorectal cancer is one of the leading causes of cancer deaths in both men and women in the world. However, colon cancer can be prevented to some extent by consumption of edible natural products with chemopreventive properties. Therefore, we investigated, whether edible mushroom Pleurotus ostreatus (PO) has chemopreventive effect on inflammation-associated colon carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and promoted by dextran sodium sulfate (DSS). PO treatment, at both doses (100 and 500 mg/kg), significantly reduced by 50 and 78% the number of aberrant crypt foci and the multiplicity of colon neoplasms by 43 and 89%, respectively. However, incidence of colon tumors and high grade dysplasia was reduced by 50 and 63% only in the dose 500 mg/kg of PO, respectively. Colon shortening and dysplastic index was significantly reduced by PO treatment in dose-dependent manner. The immunohistochemistry of colons revealed that treatment with PO suppressed expression of cyclin D1, Ki-67, COX-2 and F4/80. In summary, our data suggest that PO may prevent inflammation-associated colon carcinogenesis with exposure to PhIP through combined modulatory mechanisms of inflammation and tumor growth via suppression of COX-2, F4/80, Ki-67 and cyclin D1 expression in mice.

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“…Some studies have even reported that inflammatory response to UVA exposure causes protein denaturation, DNA damage, and oxidative stress [30]. Macrophages are an important trigger of this response by secreting inflammatory mediators when activated [31]. We therefore evaluated whether the F. suspensa bioactives have anti-inflammatory activity in vitro with LPS-challenged RAW 264.7 cells.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage

Jin¹,

Zhao²,

Yuan³

et al. 2014

JFNR

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Chronic exposure to ultraviolet (UV) radiation affects diverse constituents of skin and induces photoaging. Current therapeutic approaches cannot fully reverse the pathophysiology of photoaging, thus necessitating the discovery of new strategies to protect skin from UV radiation. Natural products have long been reported to possess photoprotective effects. Herein, we investigated the potential anti-UVA effects of forsythiaside A, forsythiaside B, and phillyrin extracted from Forsythia suspensa (Thunb.) Vahl. In vitro, all three compounds significantly prevented cytotoxicity, DNA damage, apoptosis, and cell-cycle arrest caused by a low dose of UVA. All three compounds also inhibited the expression of inflammatory cytokines. Collectively, our results suggest that these three compounds could be preventives against UVA-induced skin damage.

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Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum

Cited by 156 publications

References 72 publications

<i>In vitro</i> Protective Effect of Ganoderol A Isolated from <i>Ganadermalucidum</i> Against Ultraviolet A Radiation and its Anti-inflammatory Properties

<i>In vitro</i> Protective Effect of Ganoderol A Isolated from <i>Ganadermalucidum</i> Against Ultraviolet A Radiation and its Anti-inflammatory Properties

Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice

Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage

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