Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin

StClair, D; Wan, X. Steven; Kuroda, Masahiro; Vichitbandha, S; Tsuchida, Emiko; Urano, M

doi:10.3892/or.4.4.753

Cited by 11 publications

(10 citation statements)

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“…Generation of reactive oxygen species (ROS) has been implicated in the etiology of a diversity of human diseases, including cancer [4]. SOD catalyzes the dismutation of superoxide radical (O 2 Ϫ ) to H 2 O 2 and O 2 .…”

Section: Introductionmentioning

confidence: 99%

No apparent association between genetic polymorphisms (−102 C>T) and (−9 T>C) in the human manganese superoxide dismutase gene and gastric cancer1

Martin

Lan

Hughes

et al. 2005

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 99%

No apparent association between genetic polymorphisms (−102 C>T) and (−9 T>C) in the human manganese superoxide dismutase gene and gastric cancer1

Martin

Lan

Hughes

et al. 2005

Journal of Surgical Research

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“…Antioxidant enzymes such as superoxide dismutase have been demonstrated to protect cells from oxidative stress. Generation of ROS has been implicated in the etiology of a diversity of human diseases, including cancer [9]. Oxidative stress has been demonstrated to induce cell death as a result of excessive cellular damage associated with lipid peroxidation and alterations of nucleic acids and proteins, triggering apoptosis through the mitochondria [10].…”

Section: Introductionmentioning

confidence: 99%

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

et al. 2006

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Background Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress. A genetic polymorphism in the mitochondrial targeting sequence of this gene has been associated with increased cancer risk and survival in breast cancer. This base pair transition (-9 T > C) leads to a valine to alanine amino acid change in the mitochondrial targeting sequence. A polymorphism has also been identified in the proximal region of the promoter (-102 C>T) that alters the recognition sequence of the AP-2 transcription factor, leading to a reduction in transcriptional activity. The aim of our study was to investigate possible associations of the -102 C>T polymorphism with overall and relapse-free breast cancer survival in a hospital-based case-only study.

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“…Generation of reactive oxygen species (ROS) has been implicated in the etiology of a diversity of human diseases, including cancer[1], aging[2], atherosclerosis[3] and neurodegenerative diseases[4,5]. Superoxide dismutase catalyzes the dismutation of superoxide radical (O 2 - ) to H 2 O 2 and O 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Interest in this relative deficiency of SOD activity has been greatly increased by observations that over-expression of SOD in tumor cells will suppress cell division in culture and tumor growth in vivo[11]. In addition recent reports have suggested a possible association between decreased SOD activity and malignant phenotype[12].…”

Section: Introductionmentioning

confidence: 99%

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Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

et al. 2004

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Background: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species constituting a major cellular defense mechanism against agents that induce oxidative stress. The MnSOD promoter contains an activator protein-2 (AP-2) binding site that modifies transcription of MnSOD. Mutations have been identified in the proximal region of the promoter in human tumor cell lines. One of these mutations (-102C>T) has been shown to change the binding pattern of AP-2 leading to a reduction in transcriptional activity. The aim of our study was to develop a method to identify and determine the frequency of this (-102C>T) polymorphism in human tissues.

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Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin

Cited by 11 publications

References 0 publications

No apparent association between genetic polymorphisms (−102 C>T) and (−9 T>C) in the human manganese superoxide dismutase gene and gastric cancer1

No apparent association between genetic polymorphisms (−102 C>T) and (−9 T>C) in the human manganese superoxide dismutase gene and gastric cancer1

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

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