Suppression of visual perception by magnetic coil stimulation of human occipital cortex

Amassian, Vahé E.; Cracco, Roger Q.; Maccabee, Paul J.; Cracco, Joan B.; Rudell, Alan P.; Eberle, L.

doi:10.1016/0168-5597(89)90036-1

Cited by 513 publications

(318 citation statements)

References 14 publications

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“…Previous theoretical studies [10,8] have demonstrated that a brief magnetic pulse (less than 1 ms duration), commonly used in TMS, can generate an action potential in a straight axonal "ber. Nevertheless, TMS typically demonstrates e!ects including a long inhibitory period (a few hundred ms) as observed in EMG [3] and visual perception [1,5].…”

Section: Introductionmentioning

confidence: 99%

A model of magnetic stimulation of neocortical neurons

et al. 2001

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Transcranial magnetic stimulation (TMS) has been widely used in studies of human motor and cognitive functions as well as in clinical treatment. Biophysical mechanism underlying its e!ect is, however, largely unknown. Here, we develop a theory to calculate the e!ect of magnetic stimulation on arbitrary neuronal structure. Then, we employ a computer simulation which combines a realistic multicompartmental model of neocortical neurons and the calculation of the induced electric "eld. The simulation shows that a single magnetic pulse applied to model cortical neurons can induce brief burst "ring followed by a silent period of duration comparable to experimental data of TMS. Our simulation o!ers a new clue to understand physiology of TMS by demonstrating that magnetic stimulation acts on biophysics of the dendrites in neocortical neurons.

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Section: Introductionmentioning

confidence: 99%

A model of magnetic stimulation of neocortical neurons

et al. 2001

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“…It is in this disruptive mode that we used TMS. The technique has been used to study the timing and localization of visual processing and hemispheric asymmetry (Amassian et al 1989(Amassian et al , 1993, motion perception (Hotson et al 1994;Beckers & Zeki 1995), attentional processes (Pascual Leone et al 1994) and perceptual learning ).…”

Section: Introductionmentioning

confidence: 99%

Task–specific impairments and enhancements induced by magnetic stimulation of human visual area V5

Walsh

Ellison

Battelli

et al. 1998

Proc. R. Soc. Lond. B

189

111

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Transcranial magnetic stimulation (TMS) can be used to simulate the e¡ects of highly circumscribed brain damage permanently present in some neuropsychological patients, by reversibly disrupting the normal functioning of the cortical area to which it is applied. By using TMS we attempted to recreate de¢cits similar to those reported in a motion-blind patient and to assess the speci¢city of de¢cits when TMS is applied over human area V5. We used six visual search tasks and showed that subjects were impaired in a motion but not a form`pop-out' task when TMS was applied over V5. When motion was present, but irrelevant, or when attention to colour and form were required, TMS applied to V5 enhanced performance. When attention to motion was required in a motion^form conjunction search task, irrespective of whether the target was moving or stationary, TMS disrupted performance. These data suggest that attention to di¡erent visual attributes involves mutual inhibition between di¡erent extrastriate visual areas.

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“…TMS delivered appropriately in time and space can transiently block the function of neuronal networks, allowing for the creation of a time-dependent`virtual lesion' in an otherwise healthy brain. Amassian et al (1988Amassian et al ( , 1998 pioneered the use of this type of application of TMS in the study of the visual cortex. When applied to the occipital lobe at appropriate intensity, TMS blocks the detection of visual stimuli presented ca.…”

mentioning

confidence: 99%

Transcranial magnetic stimulation: studying the brain--behaviour relationship by induction of ‘virtual lesions’

Pascual‐Leone

Bartrés‐Faz²,

Keenan³

1999

Phil. Trans. R. Soc. Lond. B

389

191

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Transcranial magnetic stimulation (TMS) provides a non-invasive method of induction of a focal current in the brain and transient modulation of the function of the targeted cortex. Despite limited understanding about focality and mechanisms of action, TMS provides a unique opportunity of studying brain^behaviour relations in normal humans. TMS can enhance the results of other neuroimaging techniques by establishing the causal link between brain activity and task performance, and by exploring functional brain connectivity.

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Suppression of visual perception by magnetic coil stimulation of human occipital cortex

Cited by 513 publications

References 14 publications

A model of magnetic stimulation of neocortical neurons

A model of magnetic stimulation of neocortical neurons

Task–specific impairments and enhancements induced by magnetic stimulation of human visual area V5

Transcranial magnetic stimulation: studying the brain--behaviour relationship by induction of ‘virtual lesions’

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