Suppressive Effects of Bifidobacteria on Lipid Peroxidation in the Colonic Mucosa of Iron-Overloaded Mice

Ito, Masahiko; Sawada, Haruji; Ohishi, Kenji; Yoshida, Yoshinobu; Yokoi, Wakae; Watanabe, Teruhisa; Yokokura, Teruo

doi:10.3168/jds.s0022-0302(01)74591-2

Cited by 23 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, oral administration of Bifidobacterium bifidum strain Yakult effectively decreased colonic oxidative stress induced by an iron overload diet (17,18). It has also been reported that Streptococcus thermophilus YIT 2001 protected the colonic mucosa against oxidative stress (17).…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Bifidobacterium pseudolongum Strain Patronus and Metronidazole in the Rat Gut

Vasquez

Suau

Magne

et al. 2009

Appl Environ Microbiol

View full text Add to dashboard Cite

In the luminal contents of metronidazole-treated rats, there was a dominant Bifidobacterium species. A strain has been isolated, its 16S rRNA gene has been sequenced, and the strain has been named Bifidobacterium pseudolongum strain Patronus. In this study, using an experimental model of healthy rats, the effects of metronidazole treatment and B. pseudolongum strain Patronus administration on the luminal and mucosaassociated microbiota and on gut oxidation processes were investigated. Metronidazole treatment and the daily gavage of rats with B. pseudolongum strain Patronus increased the numbers of bifidobacteria in cecal contents and in cecal mucosa-associated microbiota compared with those in control rats. Metronidazole reduced the colonic oxidative damage to proteins. This is the first evidence that B. pseudolongum strain Patronus exerts an effect on a biomarker of oxidative damage by reducing the susceptibility to oxidation of proteins in the colon and the small bowel. Antioxidant effects of metronidazole could be linked to the bifidobacterial increase but also to other bacterial modifications.

show abstract

Section: Discussionmentioning

confidence: 99%

Differential Effects of Bifidobacterium pseudolongum Strain Patronus and Metronidazole in the Rat Gut

Vasquez

Suau

Magne

et al. 2009

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…Some reported benefits include enhanced immune system [5] and defense against pathogens [6], modulation of short-chain fatty acid (SCFA) production [7] and tight junction integrity [8], and mild improvement in iron status [9]. Proliferation of beneficial bacteria, usually lactobacilli and bifidobacteria, in the colon of the host may also be associated with reducing lipid peroxidation in colonic mucosa of intact mammals [10] [11]. The putative antioxidant effect might be due to the ability of the bacteria to scavenge free radicals, and/or an increase in antioxidant capacities of the colon contents.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Lactulose and Fructooligosaccharide on Growth Kinetics, Fermentation, and Antioxidant Activity of Common Probiotics

Lu¹,

Yeung²,

Yeung³

2018

FNS

View full text Add to dashboard Cite

Prebiotics are non-digestible oligosaccharides that selectively stimulate the growth of beneficial bacteria in the human gut. Fructooligosaccharide (FOS) is a common prebiotic found in food products and infant formula. Lactulose is primarily used as a pharmaceutical ingredient but also shows potential prebiotic activities. Our objectives were to determine and compare the effects of FOS and lactulose on: 1) growth kinetics of common probiotics in aerobic condition; 2) pH and titratable acidity after fermentation; and 3) antioxidant capacity of the probiotics. Ten probiotic and two non-probiotic strains, representing genera Lactobacillus, Bifidobacterium, Bacillus, and Escherichia were assembled. Media used for prebiotics experiment were modified to contain 2% FOS or lactulose as the sole or main carbohydrate source. All experiments were done in triplicate. In aerobic condition, most strains cultured with FOS or lactulose did not grow optimally compared to dextrose (a non-prebiotic), while all four Bifidobacterium spp. showed little growth regardless of the carbohydrate source. In anaerobic condition, lactulose and FOS fermentation of Bifidobacterium spp. yielded similar pH (p = 0.2723), but percent lactic acid, as determined by titratable acidity, was higher after lactulose fermentation (p = 0.0004). The non-probiotic strains were able to utilize both FOS and lactulose, but displayed weaker acid production and higher pH (p < 0.0001) relative to the probiotic strains. Antioxidant activity of spent medium was measured with Trolox as the reference standard. Overall, the antioxidant activity of probiotics was strain-dependent. In conclusion, lactulose supported growth activities of probiotics to a similar extent as FOS. Lactulose also stimulated higher acid production for Bifidobacterium spp. than FOS in anaerobic condition, thus it might be considered for incorporation into functional food products containing bifidobacteria.

show abstract

“…Mucosal lipid peroxide was measured by using the thiobarbituric acid reactive substance (TBARS) assay reported previously. 13) TBARS is expressed as the malondialdehyde (MDA) equivalent.…”

Section: Methodsmentioning

confidence: 99%

Preventive Effect ofStreptococcus thermophilusYIT 2001 on Dextran Sulfate Sodium-Induced Colitis in Mice

Ito

Ohishi

Yoshida

et al. 2008

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Suppressive Effects of Bifidobacteria on Lipid Peroxidation in the Colonic Mucosa of Iron-Overloaded Mice

Cited by 23 publications

References 26 publications

Differential Effects of Bifidobacterium pseudolongum Strain Patronus and Metronidazole in the Rat Gut

Differential Effects of Bifidobacterium pseudolongum Strain Patronus and Metronidazole in the Rat Gut

Comparative Analysis of Lactulose and Fructooligosaccharide on Growth Kinetics, Fermentation, and Antioxidant Activity of Common Probiotics

Preventive Effect ofStreptococcus thermophilusYIT 2001 on Dextran Sulfate Sodium-Induced Colitis in Mice

Contact Info

Product

Resources

About