Suppressor Mutants: History and Today’s Applications

Bautista, David; Carr, Joseph F; Mitchell, Angela M.

doi:10.1128/ecosalplus.esp-0037-2020

Cited by 6 publications

(2 citation statements)

References 166 publications

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“…However, the RE of Zm00001d042906 in TML418 was not high compared to in other long-ear parental lines. Gene expression is influenced by several factors, including genomic suppressors (Bautista et al 2021 ), cis-regulatory elements (Yu et al 2023 ), the presence of SNPs (Ymer et al 2002 ), and environmental factors (Napier et al 2023 ). In TML418, the low RE of Zm00001d042906 may be attributed to SNPs that alter amino acids in the conserved region of the gene (Fig.…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel marker and its associated laccase gene for regulating ear length in tropical and subtropical maize lines

Bi,

Jiang,

Zhang

et al. 2024

Theor Appl Genet

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Key message This study revealed the identification of a novel gene, Zm00001d042906, that regulates maize ear length by modulating lignin synthesis and reported a molecular marker for selecting maize lines with elongated ears. Abstract Maize ear length has garnered considerable attention due to its high correlation with yield. In this study, six maize inbred lines of significant importance in maize breeding were used as parents. The temperate maize inbred line Ye107, characterized by a short ear, was crossed with five tropical or subtropical inbred lines featuring longer ears, creating a multi-parent population displaying significant variations in ear length. Through genome-wide association studies and mutation analysis, the A/G variation at SNP_183573532 on chromosome 3 was identified as an effective site for discriminating long-ear maize. Furthermore, the associated gene Zm00001d042906 was found to correlate with maize ear length. Zm00001d042906 was functionally annotated as a laccase (Lac4), which showed activity and influenced lignin synthesis in the midsection cells of the cob, thereby regulating maize ear length. This study further reports a novel molecular marker and a new gene that can assist maize breeding programs in selecting varieties with elongated ears.

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Section: Discussionmentioning

confidence: 99%

Identification of a novel marker and its associated laccase gene for regulating ear length in tropical and subtropical maize lines

Bi,

Jiang,

Zhang

et al. 2024

Theor Appl Genet

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“…Selection and analysis of compensatory mutations have a long history of use to determine the structure and function of molecular machines and regulatory pathways by revealing genes that interact with focal deleterious mutations (44). Compensatory mutations can also promote evolvability by influencing the form of the adaptive landscape (31,(45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

Mutations iniclRincrease evolvability by facilitating compensation that exposes cryptic beneficial mutations in experimental populations ofEscherichia coli

Staples,

Cooper

2024

Preprint

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Evolvability describes the potential of a population to generate beneficial variation. Several mechanisms that increase evolvability have been demonstrated, including the action of systems that reveal accumulated beneficial variants following an environmental shift. We examine the basis of an increase in the evolvability ofEscherichia colilines that were first selected in an environment supplemented with glucose as sole carbon source and then transferred to an otherwise identical lactose supplemented environment. These lines increased in fitness significantly more quickly in the lactose environment, and reached a higher final fitness, than did naïve ancestral lines. In four of six lines this increased evolvability can be explained by mutations iniclRthat were selected in glucose but were significantly deleterious in lactose, masking the effect of other generally beneficial mutations. Secondary mutations that compensated for this cost resulted in large fitness increases. We did not detect any consistent genetic signature associated with the compensation, suggesting that different pathways were responsible and, therefore, that it can occur at a relatively high rate. That mutations selected in one environment will become deleterious following an environmental shift, so that compensation provides potential for a large subsequent fitness increase represents a potentially common and general mechanism of evolvability in changing environments.

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Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases

Liang¹,

Zhao²,

Kwan³

et al. 2023

Journal of Biological Chemistry

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Suppressor Mutants: History and Today’s Applications

Cited by 6 publications

References 166 publications

Identification of a novel marker and its associated laccase gene for regulating ear length in tropical and subtropical maize lines

Identification of a novel marker and its associated laccase gene for regulating ear length in tropical and subtropical maize lines

Mutations iniclRincrease evolvability by facilitating compensation that exposes cryptic beneficial mutations in experimental populations ofEscherichia coli

Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases

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