Suprachoroidal Drug Infusion for the Treatment of Severe Subfoveal Hard Exudates

Abstract

Suprachoroidal infusion of drugs can be effective in reabsorbing massive SHE.

Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles

“…We and others have previously reported using the suprachoroidal space for drug targeting to the choroid and adjacent retina to reach posterior segment targets (Morales-Canton V, et al IOVS 2013;54:ARVO EAbstract 3299). [17][18][19][20][21][22][23] Here, we accessed the ciliary body in the anterior segment by injecting drug into the most anterior portion of the suprachoroidal space, which we are calling the supraciliary space. By localizing the drug in the supraciliary space, we expected to achieve high drug levels locally in the adjacent ciliary body.…”

“…[17][18][19][20][21][22][23] Researchers have Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc. www.iovs.org j ISSN: 1552-5783 accessed the suprachoroidal space using surgically introduced catheters and conventional hypodermic needles, but more recently, our group introduced the use of microneedles as a simple and reliable method for suprachoroidal injection that is expected to be suitable for use as a rapid office procedure. 19 A first-in-humans study recently demonstrated injection of bevacizumab into the suprachoroidal space of four human eyes by using a microneedle (Morales-Canton V, et al IOVS 2013;54:ARVO E-Abstract 3299).…”

Posterior Segment Drug Delivery Devices: Current and Novel Therapies in Development

“…53 Rizzo et al evaluated the safety and efficacy of suprachoroidal delivery of a combination of 1.25 mg bevacizumab and 4.0 mg TA via iTrack microcatheter in 6 eyes with chronic macular edema secondary to DME and RVO. 54 A phase I/II clinical trial of human umbilical tissue-derived cells (CNTO 2476) is being conducted for atrophic AMD. Recently, the POSTERIOR SEGMENT DRUG DELIVERY DEVICES iTrack microcatheter has been used for cell transplantation into the subretinal space.…”

The suprachoroidal space as a route of administration to the posterior segment of the eye

“…The retinal pigment epithelium and pigmented choroid serve as a readily identifiable plane to dissect to. Once the sclerotomy is completed, a blunt-tipped catheter can be used to tunnel through the SCS towards the posterior pole[28, 32, 33, 37, 40, 41]. A catheter with a flashing diode has been used to visualize the advancement of the catheter under a microsurgical scope[28, 33].…”