Suprachoroidal Injection of Sodium Hyaluronate as an ‘Internal’ Buckling Procedure

Abstract

Various fractions of sodium hyaluronate were injected into the suprachoroidal space of rabbit eyes via the pars plana as ‘internal’ buckles. The areas of elevated choroid were diffuse, usually extending over approximately one quadrant. The buckling effect was short-lived, in the range of 12–72 h, but sodium hyaluronate actually survived in the suprachoroidal space up to 10–14 days or more. No significant differences between buckles created by sodium hyaluronate 1 and 2%, or by cross-linked sodium hyaluronate were observed. Internal buckling of the choroid may prove to be a viable adjunct or alternative to conventional buckling procedures in the future.

Suprachoroidal Drug Delivery to the Back of the Eye Using Hollow Microneedles

“…These volumes are somewhat lower than typical intravitreal injections of 50–100 μL (25). However, previous studies on rabbits have shown that the suprachoroidal space can accommodate fluid up to several hundred microliters in vivo (26), which is supported by our preliminary data using microneedles in rabbits in vivo too (data not shown). We therefore conclude that volumes suitable to administer drug doses of use for ophthalmic applications can probably be administered using microneedle injection into the suprachoroidal space.…”

Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes

“…However, it has been demonstrated that the in vivo rabbit eye can accommodate SCS injections of up to 200 L sodium hyaluronate or perfluorocarbon gases. 23,24 Therefore, it is likely that the larger canine, porcine, or human eye would also tolerate SCS injection volumes capable of large (200 -250 L) posterior segment distribution.…”

Suprachoroidal Layer and Suprachoroidal Space Delineating the Outer Margin of the Choroid in Swept-Source Optical Coherence Tomography

“…12,13 Olsen et al presented that triamcinolone injected into the SCS into a porcine eye was detectable for at least 4 months (Olsen TW et al IOVS; 2006:473. ARVO E-Abstract 3882).…”