Supramolecular nanoparticle carriers self-assembled from cyclodextrin- and adamantane-functionalized polyacrylates for tumor-targeted drug delivery

Ang, Chung Yen; Tan, Siyu; Wang, Xiaoling; Zhang, Quan; Khan, Majad; Bai, Linyi; Selvan, Subramanian Tamil; Ma, Xueli; Zhu, Liangliang; Nguyen, Kim Truc; Tan, Nguan Soon; Zhao, Yanli

doi:10.1039/c3tb21325k

Cited by 75 publications

(60 citation statements)

References 57 publications

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“…In vivo study using the nanoparticles showed good tumor growth inhibition in nude mice bearing tumors. 227 Ma and co-workers also developed supramolecular nanoparticles by conjugating β-CD onto the polymer side chain as a pendant for drug delivery. A block copolymer containing hydrophilic PEG segment and polyaspartamide bearing β-CD units (PEG-β-PCD) was synthesized.…”

Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

2014

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Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

2014

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“…The nanoparticles showed excellent blood circulation and selective 95 accumulation in tumor cells, being able to inhibit tumor growth in vivo. 146 It is known that PEG makes the nanocarriers to be silent at the blood stream, but may hinder endosomal escape after cellular uptake. To solve this dilemma, several strategies involving supramolecular assemblies have been tested.…”

Section: Host-guest Assembled Systemsmentioning

confidence: 99%

Supramolecular cyclodextrin-based drug nanocarriers

2015

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Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances. CDs can perform as multifunctionalizable cores to which very diverse (macro)molecules and drugs can be conjugated. Grafting with amphiphilic molecules can lead to nanoassemblies exhibiting a variety of architectures. CDs can also polymerize with other CDs or can be used to functionalize preexisting polymers to form polymers/networks with enhanced capability to form inclusion complexes. Alternatively, CDs can be exploited as transient cross-linkers to form poly(pseudo)rotaxane-based networks or zipper-like assemblies. Combination of mutifunctionality and complexation ability of CDs has been shown to be useful to develop depot-like formulations and colloidal nanocarriers with improved performances regarding easiness of administration, protection of the encapsulated substances, control of the delivery rate, and cell interactions. The aim of this review is to provide an overall view of the diversity of designs of CD-based supramolecular nanosystems with a special focus on the advances materialized in the last five years, including clinical trials.

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“…They are produced from synthetic polymers such as poly(lactic-coglycolic acid) (PLGA) [69], polyacrylate [70] and poly(glycidyl methacrylate) [71] or natural polymers such as chitosan, albumin or alginate. Polymeric nanoparticles can be further categorized as biodegradable (e.g., PLGA [69], albumin [72]) or nonbiodegradable (e.g., polystyrene [73]).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Therapeutic and Safety Considerations of Nanoparticle-Mediated Drug Delivery in Pregnancy

Keelan

Leong

et al. 2015

Nanomedicine (Lond.)

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Advances in nanotechnology have resulted in the design of effective, safe and tissue-selective nanocarriers for delivering therapeutics to treat malignancies, infections and other diseases. In pregnancy, nanoparticle-based drug formulations could have the potential to selectively target either the placenta and/or fetus, enabling 'fetal-friendly' drugs to be administered in pregnancy with minimal risk of off-target effects. A considerable amount of research has been carried out on maternal-placental-fetal nanoparticle uptake, transfer and toxicity using rodent and ex vivo models. However, the development of placental targeting strategies and the therapeutic evaluation of nanoformulations in pregnancy remains in its infancy. While some promising avenues are currently under investigation, much work is needed to bring the advantages of nanoparticle-based drug therapy in pregnancy to clinical reality.

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Supramolecular nanoparticle carriers self-assembled from cyclodextrin- and adamantane-functionalized polyacrylates for tumor-targeted drug delivery

Cited by 75 publications

References 57 publications

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

Supramolecular cyclodextrin-based drug nanocarriers

Therapeutic and Safety Considerations of Nanoparticle-Mediated Drug Delivery in Pregnancy

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